Investigating how certain proteins affect the esophagus in children with eosinophilic esophagitis
The role of serpins and LRP1 in the esophageal epithelium during eosinophilic esophagitis
This study is looking at how a part of the esophagus works in kids with eosinophilic esophagitis (EoE) to find out why it sometimes doesn't protect them from allergens, with the hope of discovering new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11091647 on NIH RePORTER |
What this research studies
This research focuses on eosinophilic esophagitis (EoE), a chronic allergic condition affecting the esophagus, particularly in children. It aims to understand how the esophageal epithelium, which serves as a barrier against allergens, functions and fails in EoE. The study will explore the roles of specific proteins, such as serpins and LRP1, in maintaining this barrier and how their dysfunction may lead to allergic responses. By examining these mechanisms, the research seeks to identify potential therapeutic targets for improving treatment outcomes for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with eosinophilic esophagitis.
Not a fit: Patients who do not have eosinophilic esophagitis or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the quality of life for children suffering from eosinophilic esophagitis.
How similar studies have performed: Previous research has shown promising results in understanding the role of protease inhibitors in allergic diseases, suggesting that this approach may yield beneficial insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Azouz, Nurit P — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Azouz, Nurit P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.