Investigating how specific T cells move to the esophagus in Eosinophilic Esophagitis
Official title: The Role of the GPR15-C10ORF99 Pathway in T cell Homing during Eosinophilic Esophagitis
Funded at Thomas Jefferson University · NIH-11116740 · Data updated 2026-11-12
This study is looking into how certain immune cells move to the esophagus and cause problems for people with Eosinophilic Esophagitis (EoE), with the goal of finding new and easier ways to diagnose and treat this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $226,980 |
| NIH project number | 1R21AI190614-01 |
| Project ID | NIH-11116740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Eosinophilic Esophagitis who experience symptoms such as difficulty swallowing or food impaction.
✕Less likely to help
Patients with other esophageal conditions unrelated to Eosinophilic Esophagitis may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind Eosinophilic Esophagitis (EoE), a chronic inflammatory condition affecting the esophagus. It aims to explore the role of specific T helper cells that migrate to the esophagus and how this migration contributes to the symptoms of EoE. By studying the GPR15-C10ORF99 pathway, the research seeks to identify potential new diagnostic and treatment strategies that could be less invasive and more effective for patients suffering from EoE.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and more effective treatments for patients with Eosinophilic Esophagitis.
How similar studies have gone: Previous research has shown promising results in understanding T cell migration in other inflammatory conditions, suggesting potential for success in this area as well.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Kim, Sangwon Vincent — Thomas Jefferson University
- Study coordinator: Kim, Sangwon Vincent
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.