Exploring esophageal distensibility changes with proton pump inhibitors in eosinophilic esophagitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the relationship between eosinophilic inflammation in the esophagus and its distensibility after treatment with proton pump inhibitors. It aims to measure the distensibility of both the proximal and distal esophagus using the EndoFlip technology, before and after treatment. The study focuses on patients with eosinophilic esophagitis, specifically looking at changes in esophageal function related to eosinophilia. By assessing distensibility across different segments of the esophagus, the study seeks to provide insights into the effects of treatment on esophageal health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1\. Presence of eosinophilia on esophageal biopsy, defined as a peak count of \> 15 eosinophils per high power field (HPF) on light microscopy based on biopsies from at least 2 of the 3 biopsy segments (upper, middle and distal esophagus)

Exclusion Criteria:

1. Secondary causes of esophageal eosinophilia has been excluded, such as eosinophilic GI diseases, celiac disease, Crohn's disease, esophageal infection, hypereosinophilic syndrome, drug hypersensitivity, vasculitis, pemphigus, connective tissue diseases, graft vs. host disease
2. Age \< 18 or \> 65 years
3. Contraindication for biopsy, such as presence of esophageal varices, coagulopathy
4. History of esophageal surgery, gastric or esophageal malignancy, anatomical abnormality, or major primary motility disorder (such as achalasia)
5. Pregnancy
6. Prisoners

Where it's running

• Indiana University Health University Hospital
  Indianapolis, Indiana, United States Recruiting
• Indiana University
  Indianapolis, Indiana, United States Recruiting

Study contacts

• Principal investigator: Akiro Saito, MD — Indiana University
• Study coordinator: Maureen Schilling
• Email: maschi@iu.edu

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.