Understanding how immune responses affect the esophagus in children with eosinophilic esophagitis
Molecular Mechanisms of Reactive Epithelial Changes in Pediatric Eosinophilic Esophagitis
This study is looking at how certain immune responses affect the esophagus in kids with eosinophilic esophagitis (EoE), using special lab techniques to help find better ways to understand and treat this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11059936 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that lead to changes in the esophagus of children suffering from eosinophilic esophagitis (EoE), a condition characterized by inflammation and hyperplasia of the esophageal cells. The study employs advanced techniques such as 3D organoid culture systems and flow cytometry to explore how immune responses contribute to these changes. By using a mouse model that mimics early onset EoE, researchers aim to uncover the role of specific proteins in the disease process, which could lead to better understanding and treatment options for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with eosinophilic esophagitis.
Not a fit: Patients who do not have eosinophilic esophagitis or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for children with eosinophilic esophagitis.
How similar studies have performed: Other research has shown promise in understanding immune-mediated diseases, but this specific approach to studying eosinophilic esophagitis in children is relatively novel.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Bailey, Dominique — Columbia University Health Sciences
- Study coordinator: Bailey, Dominique
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.