Role of 1q21 Genetic Variants in Eosinophilic Esophagitis
Official title: Role of NOD2 Variants in Eosinophilic Esophagitis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11353128 · Data updated 2026-11-12
This project looks at how genetic differences may make some people with allergies more likely to develop eosinophilic esophagitis (EoE).
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2006 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $374,455 |
| NIH project number | 2U19AI070235-21 |
| Project ID | NIH-11353128 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with eosinophilic esophagitis or related atopic conditions who may carry 1q21/CRNN genetic variants could be potential candidates for future translational applications.
✕Less likely to help
People without atopy or EoE or without relevant genetic risk factors may not benefit from this research.
What this research studies
Eosinophilic esophagitis is a food-triggered allergic inflammation of the esophagus that affects some people with atopic diseases. The study uses a multi-trait genome-wide approach to explore shared genetic factors, focusing on the 1q21 region and the CRNN gene, in order to understand why EoE arises in a subset of allergic patients. Researchers will test how 1q21 variants influence CRNN expression and how this interaction contributes to EoE and related atopic conditions. The work aims to identify genetic mechanisms that could eventually inform targeted prevention or treatment strategies for affected patients.
Why it matters
Potential benefit: Understanding genetic risk and mechanisms could lead to better diagnosis, risk prediction, and personalized approaches for prevention or management of EoE in susceptible individuals.
How similar studies have gone: Previous work has linked 1q21 and epidermal differentiation complex variants to EoE and atopy, making this approach plausible but still an area of active discovery.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Rothenberg, Marc E. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Rothenberg, Marc E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.