Evaluating gastrointestinal eosinophilic disorders in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the prevalence and incidence of eosinophilic gastrointestinal disorders (EGIDs) in pediatric patients across multiple centers in Italy. It focuses on conditions such as eosinophilic esophagitis, gastritis, gastroenteritis, and colitis, which are increasingly recognized but poorly understood. By collecting data from patients aged 0-18 years, the study seeks to provide clearer epidemiological insights into these disorders and improve diagnostic and therapeutic guidelines. Informed consent will be obtained from patients and their guardians for participation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- All EGIDs patients aged 0-18 years and followed at the centers involved in the study will be considered eligible. Informed consent must be obtained from each enrolled patient and signed by a parent/legal guardian and patient (when older than six years).

Exclusion Criteria:

\- This study will not include patients with:

1. a diagnosis of EGIDs made more than five years before the study participation;
2. a diagnosis of EoE not in line with current international guidelines;
3. a secondary cause of intestinal eosinophilic inflammation (inflammatory bowel diseases, autoimmune diseases, vasculitis, graft versus host disease, malignancies).

Where it's running

• IRCCS Policlinico San Matteo
  Pavia, Italy Recruiting

Study contacts

• Study coordinator: Amelia Licari, MD
• Email: a.licari@smatteo.pv.it
• Phone: +390382502629

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Registry for Eosinophilic Gastrointestinal Disorders

  This study is collecting information from people with Eosinophilic Gastrointestinal Disorders to better understand their symptoms and improve treatments for them.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT05199532

• Evaluating outcomes in eosinophilic gastrointestinal disorders

  This study is trying to find the best ways to measure how well people with eosinophilic gastrointestinal disorders are doing by looking at their symptoms and tissue samples over time.

  Recruiting at 16 sites Children's Hospital Medical Center, Cincinnati · Phoenix, Arizona and 18 other locations · NCT02523118

• Upadacitinib for Eosinophilic Esophagitis in adults not responding to standard therapy

  This study tests whether upadacitinib, taken with topical corticosteroids, can reduce disease activity in adults with eosinophilic esophagitis who still have symptoms.

  Recruiting Phase 2 University of North Carolina, Chapel Hill · Chapel Hill, North Carolina and 1 other locations · NCT07588568

• A registry for adults with esophageal movement and reflux problems.

  This project will collect esophageal function tests (manometry, pH-impedance, FLIP) and clinical data from adults with reflux or swallowing symptoms to see if combining these results helps guide diagnosis and long-term care.

  Recruiting IRCCS San Raffaele · Milan, Lombardy · NCT07506746

• Using a mucosal impedance device to help diagnose chronic esophageal problems

  This test tries a mucosal impedance device during upper endoscopy to see if it helps diagnose people with chronic reflux (GERD) or eosinophilic esophagitis.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT07227506

• Esophageal string test to screen for eosinophilic esophagitis in adults of African descent with swallowing problems

  This study will test whether a 1-hour esophageal string test can detect eosinophilic esophagitis in adults born in Africa (or with African parents) who have trouble swallowing.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 2 other locations · NCT07027826

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.