Investigating the role of mitochondria in eosinophilic esophagitis
Mitochondria in eosinophilic esophagitis pathogenesis
This study is looking at how a protein called IL-13 affects the cells in the esophagus of people with eosinophilic esophagitis (EoE), which could help us find new ways to understand and diagnose this condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11164724 on NIH RePORTER |
What this research studies
This research focuses on eosinophilic esophagitis (EoE), a chronic condition driven by food allergies and immune responses. It examines how the protein interleukin-13 (IL-13) affects mitochondrial function in esophageal cells, potentially leading to inflammation and tissue changes. The study aims to uncover the molecular mechanisms behind these effects and explore the possibility of using mitochondrial changes as biomarkers for EoE. Patients may benefit from a better understanding of their condition and new diagnostic tools.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with eosinophilic esophagitis, particularly those experiencing severe symptoms related to food allergies.
Not a fit: Patients without eosinophilic esophagitis or those whose condition is unrelated to mitochondrial function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted therapies for patients with eosinophilic esophagitis.
How similar studies have performed: Previous research has shown promising results in understanding the role of IL-13 in eosinophilic esophagitis, but the specific focus on mitochondrial biology is a novel approach.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Whelan, Kelly a — Temple Univ of the Commonwealth
- Study coordinator: Whelan, Kelly a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.