Understanding how environmental factors influence eosinophilic esophagitis
Official title: Mechanisms of aryl hydrocarbon receptor control of eosinophilic esophagitis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10938426 · Data updated 2026-11-12
This study is looking at how certain things in our environment, like food and air pollution, can affect eosinophilic esophagitis (EoE) and how a specific protein in our body might help protect or worsen this condition, so patients can learn more about how their surroundings impact their health and discover new treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $623,589 |
| NIH project number | 1R01DK140127-01 |
| Project ID | NIH-10938426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with eosinophilic esophagitis, particularly those experiencing severe allergic reactions.
✕Less likely to help
Patients without eosinophilic esophagitis or those whose condition is not influenced by environmental factors may not benefit from this research.
What this research studies
This research investigates the role of the aryl hydrocarbon receptor (AHR) in eosinophilic esophagitis (EoE), an allergic condition affecting the esophagus. It explores how various environmental stimuli, such as dietary components and air pollutants, can trigger allergic responses by disrupting the epithelial barrier. The study aims to identify the molecular mechanisms by which AHR can either protect against or worsen EoE, focusing on its ability to regulate immune responses and maintain barrier integrity. Patients may benefit from insights into how their environment influences their condition and potential new therapeutic approaches.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for eosinophilic esophagitis by identifying environmental factors that can be modified to reduce allergic responses.
How similar studies have gone: Previous research has shown that understanding the role of environmental factors in allergic diseases can lead to significant advancements in treatment strategies.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Azouz, Nurit P — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Azouz, Nurit P
Related research
Other NIH-funded projects on the same topics.
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Esophageal antigen test-guided diet for eosinophilic esophagitis
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Allergic eosinophilic esophagitis drives dysregulated innate immunity in esophageal fibroblasts
This project studies why eosinophilic esophagitis, a chronic food allergy-related condition, causes lasting changes in the esophagus and how these changes could be treated to prevent scarring and complications.
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How environmental signals and a receptor may protect or worsen eosinophilic esophagitis
A new NIH grant is exploring how the aryl hydrocarbon receptor (AHR) in the esophagus affects eosinophilic esophagitis (EoE) and how environmental factors might influence this condition.
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Toward personalized care for pediatric eosinophilic esophagitis using multimodal biomarkers
A pediatric-focused study will combine biochemical, structural, and molecular signals from the esophagus to better tailor treatment for kids with eosinophilic esophagitis.
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Role of protective proteins in the esophagus to treat eosinophilic esophagitis
A research project aims to understand how certain proteins protect or restore the esophageal lining in children with eosinophilic esophagitis and how this could lead to better long-lasting therapies.
-
Role of 1q21 Genetic Variants in Eosinophilic Esophagitis
This project looks at how genetic differences may make some people with allergies more likely to develop eosinophilic esophagitis (EoE).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.