Understanding how environmental factors influence eosinophilic esophagitis
Mechanisms of aryl hydrocarbon receptor control of eosinophilic esophagitis
This study is looking at how certain things in our environment, like food and air pollution, can affect eosinophilic esophagitis (EoE) and how a specific protein in our body might help protect or worsen this condition, so patients can learn more about how their surroundings impact their health and discover new treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10938426 on NIH RePORTER |
What this research studies
This research investigates the role of the aryl hydrocarbon receptor (AHR) in eosinophilic esophagitis (EoE), an allergic condition affecting the esophagus. It explores how various environmental stimuli, such as dietary components and air pollutants, can trigger allergic responses by disrupting the epithelial barrier. The study aims to identify the molecular mechanisms by which AHR can either protect against or worsen EoE, focusing on its ability to regulate immune responses and maintain barrier integrity. Patients may benefit from insights into how their environment influences their condition and potential new therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with eosinophilic esophagitis, particularly those experiencing severe allergic reactions.
Not a fit: Patients without eosinophilic esophagitis or those whose condition is not influenced by environmental factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for eosinophilic esophagitis by identifying environmental factors that can be modified to reduce allergic responses.
How similar studies have performed: Previous research has shown that understanding the role of environmental factors in allergic diseases can lead to significant advancements in treatment strategies.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Azouz, Nurit P — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Azouz, Nurit P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.