Investigating how FOXM1 contributes to eosinophilic esophagitis
Official title: The Role of FOXM1 in Eosinophilic Esophagitis Pathogenesis
Funded at Children's Hosp of Philadelphia · NIH-10724896 · Data updated 2026-11-12
This study is looking at how a protein called FOXM1 might cause problems in the esophagus for people with eosinophilic esophagitis (EoE), which makes it hard to swallow, and aims to find new ways to help improve treatments for this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $178,000 |
| NIH project number | 1R03TR004578-01 |
| Project ID | NIH-10724896 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with eosinophilic esophagitis who experience symptoms such as dysphagia or food impaction.
✕Less likely to help
Patients without eosinophilic esophagitis or those with other unrelated gastrointestinal disorders may not benefit from this research.
What this research studies
This research focuses on eosinophilic esophagitis (EoE), a chronic allergic condition affecting the esophagus, leading to symptoms like difficulty swallowing and food impaction. The study aims to understand the role of a protein called FOXM1 in disrupting the normal function of esophageal cells, which may contribute to inflammation and other complications in EoE. Using advanced cell culture techniques, researchers will explore how FOXM1 affects the behavior of esophageal cells when exposed to specific inflammatory signals. The ultimate goal is to identify potential therapeutic targets that could improve treatment options for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate symptoms and improve the quality of life for patients with eosinophilic esophagitis.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammatory pathways in eosinophilic esophagitis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Muir, Amanda Brooke — Children's Hosp of Philadelphia
- Study coordinator: Muir, Amanda Brooke
Related research
Other NIH-funded projects on the same topics.
-
Esophageal antigen test-guided diet for eosinophilic esophagitis
A small, patient-friendly diet approach using a new esophageal antibody test aims to help people with eosinophilic esophagitis identify foods to avoid without repeated invasive procedures.
-
Allergic eosinophilic esophagitis drives dysregulated innate immunity in esophageal fibroblasts
This project studies why eosinophilic esophagitis, a chronic food allergy-related condition, causes lasting changes in the esophagus and how these changes could be treated to prevent scarring and complications.
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How environmental signals and a receptor may protect or worsen eosinophilic esophagitis
A new NIH grant is exploring how the aryl hydrocarbon receptor (AHR) in the esophagus affects eosinophilic esophagitis (EoE) and how environmental factors might influence this condition.
-
Toward personalized care for pediatric eosinophilic esophagitis using multimodal biomarkers
A pediatric-focused study will combine biochemical, structural, and molecular signals from the esophagus to better tailor treatment for kids with eosinophilic esophagitis.
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Role of protective proteins in the esophagus to treat eosinophilic esophagitis
A research project aims to understand how certain proteins protect or restore the esophageal lining in children with eosinophilic esophagitis and how this could lead to better long-lasting therapies.
-
Role of 1q21 Genetic Variants in Eosinophilic Esophagitis
This project looks at how genetic differences may make some people with allergies more likely to develop eosinophilic esophagitis (EoE).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.