Investigating how FOXM1 contributes to eosinophilic esophagitis
The Role of FOXM1 in Eosinophilic Esophagitis Pathogenesis
This study is looking at how a protein called FOXM1 might cause problems in the esophagus for people with eosinophilic esophagitis (EoE), which makes it hard to swallow, and aims to find new ways to help improve treatments for this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10724896 on NIH RePORTER |
What this research studies
This research focuses on eosinophilic esophagitis (EoE), a chronic allergic condition affecting the esophagus, leading to symptoms like difficulty swallowing and food impaction. The study aims to understand the role of a protein called FOXM1 in disrupting the normal function of esophageal cells, which may contribute to inflammation and other complications in EoE. Using advanced cell culture techniques, researchers will explore how FOXM1 affects the behavior of esophageal cells when exposed to specific inflammatory signals. The ultimate goal is to identify potential therapeutic targets that could improve treatment options for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with eosinophilic esophagitis who experience symptoms such as dysphagia or food impaction.
Not a fit: Patients without eosinophilic esophagitis or those with other unrelated gastrointestinal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate symptoms and improve the quality of life for patients with eosinophilic esophagitis.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammatory pathways in eosinophilic esophagitis, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Muir, Amanda Brooke — Children's Hosp of Philadelphia
- Study coordinator: Muir, Amanda Brooke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.