Investigating genetic factors in eosinophilic esophagitis
Combinatory Effects of Genetic Variants in Eosinophilic Esophagitis
This study is looking at how certain rare genetic changes might play a role in eosinophilic esophagitis (EoE) by examining the DNA of families affected by the condition, with the hope of creating tools to help identify people who may be at a higher risk for EoE.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10917389 on NIH RePORTER |
What this research studies
This research focuses on eosinophilic esophagitis (EoE), a chronic allergic condition affecting the esophagus. It aims to understand how combinations of rare genetic variants contribute to the disease by analyzing genetic data from affected families. Using advanced techniques like whole-exome sequencing and RNA sequencing, the study will explore the interactions between these genetic variants and their impact on EoE symptoms. The goal is to develop predictive risk scores that can help identify individuals at higher risk for EoE based on their genetic makeup.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a diagnosis of eosinophilic esophagitis or those with a family history of the condition.
Not a fit: Patients without eosinophilic esophagitis or those not genetically predisposed to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and personalized treatment strategies for patients with eosinophilic esophagitis.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in similar allergic conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Shoda, Tetsuo — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Shoda, Tetsuo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.