Investigating genetic factors in eosinophilic esophagitis
Official title: Combinatory Effects of Genetic Variants in Eosinophilic Esophagitis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10917389 · Data updated 2026-11-12
This study is looking at how certain rare genetic changes might play a role in eosinophilic esophagitis (EoE) by examining the DNA of families affected by the condition, with the hope of creating tools to help identify people who may be at a higher risk for EoE.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00AI158660-04 |
| Project ID | NIH-10917389 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a diagnosis of eosinophilic esophagitis or those with a family history of the condition.
✕Less likely to help
Patients without eosinophilic esophagitis or those not genetically predisposed to the condition may not benefit from this research.
What this research studies
This research focuses on eosinophilic esophagitis (EoE), a chronic allergic condition affecting the esophagus. It aims to understand how combinations of rare genetic variants contribute to the disease by analyzing genetic data from affected families. Using advanced techniques like whole-exome sequencing and RNA sequencing, the study will explore the interactions between these genetic variants and their impact on EoE symptoms. The goal is to develop predictive risk scores that can help identify individuals at higher risk for EoE based on their genetic makeup.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and personalized treatment strategies for patients with eosinophilic esophagitis.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in similar allergic conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Shoda, Tetsuo — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Shoda, Tetsuo
Related research
Other NIH-funded projects on the same topics.
-
Esophageal antigen test-guided diet for eosinophilic esophagitis
A small, patient-friendly diet approach using a new esophageal antibody test aims to help people with eosinophilic esophagitis identify foods to avoid without repeated invasive procedures.
-
Allergic eosinophilic esophagitis drives dysregulated innate immunity in esophageal fibroblasts
This project studies why eosinophilic esophagitis, a chronic food allergy-related condition, causes lasting changes in the esophagus and how these changes could be treated to prevent scarring and complications.
-
How environmental signals and a receptor may protect or worsen eosinophilic esophagitis
A new NIH grant is exploring how the aryl hydrocarbon receptor (AHR) in the esophagus affects eosinophilic esophagitis (EoE) and how environmental factors might influence this condition.
-
Toward personalized care for pediatric eosinophilic esophagitis using multimodal biomarkers
A pediatric-focused study will combine biochemical, structural, and molecular signals from the esophagus to better tailor treatment for kids with eosinophilic esophagitis.
-
Role of protective proteins in the esophagus to treat eosinophilic esophagitis
A research project aims to understand how certain proteins protect or restore the esophageal lining in children with eosinophilic esophagitis and how this could lead to better long-lasting therapies.
-
Role of 1q21 Genetic Variants in Eosinophilic Esophagitis
This project looks at how genetic differences may make some people with allergies more likely to develop eosinophilic esophagitis (EoE).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.