A new tool for diagnosing eosinophilic esophagitis in children
Official title: Dual-wavelength endoscopic Raman probe for eosinophilic esophagitis
Funded at Vanderbilt University · NIH-11127494 · Data updated 2026-11-12
This study is testing a new tool that uses light to help doctors quickly and accurately diagnose eosinophilic esophagitis (EoE) in kids, making it easier for them to get the right care without needing lots of tissue samples.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | July 1, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $405,624 |
| NIH project number | 5R01DK132338-04 |
| Project ID | NIH-11127494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are experiencing symptoms related to eosinophilic esophagitis.
✕Less likely to help
Patients who do not have eosinophilic esophagitis or are older than 11 years may not benefit from this research.
What this research studies
This research focuses on developing a dual-wavelength endoscopic Raman probe to improve the diagnosis of eosinophilic esophagitis (EoE) in children. EoE is a chronic inflammatory condition that can cause significant feeding and swallowing difficulties. The study aims to utilize Raman spectroscopy, a technique that analyzes the biochemical composition of tissues, to provide real-time diagnostic information during endoscopic procedures. By doing so, it seeks to reduce the reliance on multiple biopsies and enhance the accuracy of EoE diagnosis.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate diagnoses of eosinophilic esophagitis, improving treatment outcomes for affected children.
How similar studies have gone: Previous research has shown promise in using Raman spectroscopy for diagnostic purposes, indicating potential success for this novel approach.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Mahadevan-Jansen, Anita — Vanderbilt University
- Study coordinator: Mahadevan-Jansen, Anita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.