Effects of ECMO support on heart function during severe heart failure
Left ventricular physiological effects of veno-arterial ECMO support during cardiogenic shock
This study is looking at how a special heart support machine called VA-ECMO helps people with severe heart failure, especially focusing on how it affects the heart's left ventricle, to better understand its benefits and any possible issues for patients in critical condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10898923 on NIH RePORTER |
What this research studies
This research investigates how veno-arterial extracorporeal membrane oxygenation (VA-ECMO) affects the heart's left ventricle during cardiogenic shock, a critical condition where the heart cannot pump enough blood. The study aims to understand the physiological impacts of VA-ECMO, which is a mechanical support system that can quickly provide blood and oxygen to patients in severe heart failure. By analyzing both animal models and clinical data, the researchers hope to clarify the benefits and potential complications of this treatment approach, ultimately aiming to improve patient outcomes. Patients may be monitored for changes in heart function and recovery rates following the use of VA-ECMO.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from cardiogenic shock, particularly those who may require mechanical support like VA-ECMO.
Not a fit: Patients with stable heart function or those not experiencing cardiogenic shock may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients experiencing cardiogenic shock, potentially reducing mortality rates.
How similar studies have performed: Previous studies have shown mixed results regarding the use of VA-ECMO, indicating that while it can improve outcomes in some patients, its effects on heart function are still being explored.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Yannopoulos, Demetris — University of Minnesota
- Study coordinator: Yannopoulos, Demetris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.