Rehabilitation for patients recovering from cardiogenic shock
Official title: A framEwork for aN InteGrated assessMent of cArdiac Rehabilitation Programs in Patients Acutely Managed for Cardiogenic Shock - ENIGMA-shock
Run by Fondazione Don Carlo Gnocchi ETS · NCT06572826 · Data updated 2026-11-12
This study is testing how well cardiac rehabilitation helps people recover and improve their quality of life after experiencing cardiogenic shock.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 110 Years |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Fondazione Don Carlo Gnocchi ETS Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | August 31, 2024 |
| Main results expected | October 30, 2026 |
| Study ends | January 31, 2027 |
| Registry record updated | September 2, 2026 |
| Trial ID | NCT06572826 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with a clinical diagnosis of cardiogenic shock who are willing to provide informed consent.
✕Probably not a fit
Patients who refuse to give informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the outcomes of cardiac rehabilitation in patients who have been acutely managed for cardiogenic shock. Utilizing the Altshock registry, the largest multicenter registry for cardiogenic shock in Italy, the study will evaluate post-acute care programs, focusing on functional recovery, quality of life, and economic efficiency. It will include a cohort of approximately 2000 patients, analyzing survival rates and recovery metrics over 6 months and 1 year post-ICU discharge. The study employs a mixed-method approach to validate an innovative care model compared to traditional pathways.
Why it matters
Potential benefit: If successful, this study could improve recovery outcomes and quality of life for patients who have experienced cardiogenic shock.
How similar studies have gone: Other studies have shown promising results in cardiac rehabilitation for similar conditions, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: • All consecutive patients with a clinical diagnosis of Cardiogenic Shock. Exclusion Criteria: • Refusal to give informed consent.
Where it's running
-
Fondazione Don Gnocchi
Milan, Italy Recruiting
Study contacts
- Study coordinator: Nuccia Morici, MD
- Email: nmorici@dongnocchi.it
- Phone: 00390240308122
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Factors Influencing Outcomes in ECMO and Impella Patients
This study tests whether metabolic and thyroid hormone changes help predict survival for adults on ECMO or Impella at a single Hungarian cardiac ICU.
-
Evaluating a noninvasive tissue sensor to detect cardiogenic shock earlier in heart patients
This pilot, noninvasive study tests whether the NIRSense wearable can help detect deterioration in adults with cardiogenic shock risk due to heart attack or heart failure.
-
Safety and Efficacy of an Extracorporeal Ventricular Assist System for Cardiogenic Shock
This study tests whether an extracorporeal ventricular assist device can safely provide short-term heart support and help patients with cardiogenic shock or trouble weaning from bypass.
-
Left Ventricular Support and Advanced Monitoring in AMI–Cardiogenic Shock: Immediate Impella Use and PAC/Monitoring vs Standard Care
In adults with heart attack-related cardiogenic shock, this trial tests whether using an Impella left ventricular assist device and/or protocolized pulmonary artery catheter monitoring improves survival compared with standard care.
-
CRP Apheresis for infarct-related cardiogenic shock
This study tests whether selectively removing C-reactive protein with apheresis, in addition to standard care, helps people with cardiogenic shock after a heart attack.
-
Compare two ventilator modes in adults with cardiac ICU needs and invasive ventilation
This pilot tests whether volume-controlled versus pressure-controlled ventilation can be safely used in adults with heart disease and respiratory failure who need invasive ventilation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.