Condition

Acute Myocardial Infarction clinical trials and research

• 30Clinical trials
• 16NIH research projects
• 22Countries

Newest Acute Myocardial Infarction clinical trials

All recruiting trials (30)

• Evaluating a noninvasive tissue sensor to detect cardiogenic shock earlier in heart patients

  This pilot, noninvasive study tests whether the NIRSense wearable can help detect deterioration in adults with cardiogenic shock risk due to heart attack or heart failure.

  Recruiting NIRSense Inc. · Weston, Florida · NCT07825363

• Adenosine given before primary PCI to reduce no-reflow in STEMI patients.

  See if giving intracoronary adenosine before primary PCI lowers the chance of slow flow/no-reflow in adults with STEMI.

  Recruiting at 2 sites Phase 4 National Institute of Cardiovascular Diseases, Pakistan · Karachi, Sindh and 1 other locations · NCT07536802

• Subclinical depression in people after a first heart attack (SUBDIMA25)

  This project will test how common mild depressive symptoms are in adults hospitalized for a first heart attack and whether those symptoms relate to biomarkers, heart function, and recovery over the next year.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, Italia · NCT07492537

• Long-term follow-up after Hearticellgram-AMI treatment

  We will follow people who got one dose of Hearticellgram-AMI after a heart attack for up to 60 months to see if the treatment stays safe.

  Recruiting Pharmicell Co., Ltd. · Seoul, Gangnam · NCT07400458

• Long-term remote ischemic preconditioning after a heart attack

  This trial will test whether daily brief arm blood‑flow restriction after a recent heart attack can lower the chance of major heart and brain events over the following year for people treated for acute myocardial infarction.

  Recruiting Henan Institute of Cardiovascular Epidemiology · Zhengzhou, Henan · NCT07181356

• Using wearable devices to monitor heart attack patients

  This study tests whether wearable devices can help monitor heart attack patients in the hospital to improve their care and predict their recovery.

  Recruiting RenJi Hospital · Shanghai · NCT06995495

• Assessing heart tissue damage in patients with heart aneurysms after a heart attack

  This study is testing how heart tissue damage looks in patients with heart aneurysms after a heart attack using special imaging to see if it helps understand their condition better.

  Recruiting RenJi Hospital · Shanghai · NCT06994221

• Morphine injection near the stellate ganglion to reduce heart damage after a heart attack

  This trial tests whether a single injection of morphine around the stellate ganglion given before PCI can reduce heart muscle damage in adults with acute STEMI.

  Recruiting at 3 sites The Second Hospital of Anhui Medical University · Hefei, Anhui and 2 other locations · NCT06947135

• Effects of aerobic exercise on heart function in patients with heart disease

  This study tests whether different types of aerobic exercise can improve heart function in patients with heart disease who have recently had treatment.

  Recruiting at 2 sites Instituto de Investigación Sanitaria y Biomédica de Alicante · Alicante, Alicante and 1 other locations · NCT06788275

• Long-term follow-up of patients from the EXCELLENT trial

  This study looks at the long-term health of patients from the EXCELLENT trial to see how well the treatments they received worked over 10 years.

  Recruiting at 2 sites CellProthera · Mulhouse, France and 9 other locations · NCT06521047

• Apixaban versus warfarin for left ventricular clot after a heart attack

  This compares apixaban and warfarin to see which better clears left-ventricular blood clots in adults after a heart attack.

  Recruiting at 3 sites Phase 4 Karolinska Institutet · Falun and 15 other locations · NCT06515730

• Long-term follow-up of patients with acute myocardial infarction

  This study is trying to see how patients who have had a heart attack can be better monitored over time using new technology to improve their health and prevent future heart problems.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT06489080

• Influenza vaccination's effect on heart inflammation after a heart attack

  This study is testing if getting a flu shot after a heart attack can help reduce inflammation in the heart for patients who have just had a procedure to open blocked arteries.

  Recruiting at 3 sites Phase 4 Region Örebro County · Aarhus and 2 other locations · NCT06336317

• Registry of patients with acute cardiovascular disease in a cardiac intensive care unit

  This study is looking at patients with serious heart conditions in the Cardiac Intensive Care Unit to see how they do during and after their hospital stay.

  Recruiting University Hospital, Ioannina · Ioannina, Epirus · NCT06081205

• Investigating how menopause affects blood cell function and cardiovascular risk

  This study is testing how menopause affects blood cells and heart health in both men and women to see if hormone changes increase cardiovascular risks, especially looking at the role of hormone replacement therapy.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT05985447

• Comparing revascularization strategies for heart attack patients with cardiogenic shock

  This study is testing whether treating multiple blocked heart arteries right away helps heart attack patients in shock feel better compared to just fixing the main blockage.

  Recruiting Phase 4 Samsung Medical Center · Seoul · NCT05527717

• Early treatment with PCSK9 inhibitors after heart attack

  This study is testing if giving a new heart medication called alirocumab right after a heart attack can help patients recover better than standard treatment.

  Recruiting at 5 sites Phase 4 Shanghai Tong Ren Hospital · Shanghai, Shanghai Municipality and 4 other locations · NCT05292404

• Collaborative effort to improve care for patients with cardiogenic shock

  This study is trying to gather information on how to better care for patients with cardiogenic shock caused by heart problems to help improve their treatment and outcomes.

  Recruiting at 3 sites University of Utah · Weston, Florida and 2 other locations · NCT05185492

• Monitoring heart rhythms after a heart attack

  This study tests if using a heart monitor after a heart attack can help doctors catch dangerous heart rhythms early and improve care for patients at risk of sudden cardiac death.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05073419

• Peri-procedure SGLT-2 inhibitor to reduce heart attack damage and heart remodeling

  This trial will test whether taking an SGLT‑2 diabetes medicine around the time of PCI can shrink the heart attack scar and limit heart remodeling in adults with acute myocardial infarction who are at high risk for heart failure.

  Recruiting Phase 4 Samsung Medical Center · Seoul · NCT04899479

• Reduced-dose ticagrelor with early aspirin discontinuation after PCI for acute myocardial infarction

  This trial will see if switching to reduced‑dose ticagrelor and stopping aspirin early lowers bleeding without increasing clots in adults with acute myocardial infarction treated with Orsiro stents.

  Recruiting Phase 4 Dong-A University · Busan · NCT04755387

• Using advanced cardiac imaging to improve treatment for patients with chest pain

  This study is testing if using advanced heart imaging techniques can help people with chest pain get better treatment and feel healthier compared to standard care.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT04709900

• Using Ezetimibe After Heart Attacks

  This study tests if starting a cholesterol-lowering drug called Ezetimibe right after a heart attack can help people lower their bad cholesterol and prevent future heart problems when used with statins.

  Recruiting Cairo University · Aswān · NCT04701242

• Assessing the benefits of ICD implantation in patients with coronary artery disease after cardiac arrest

  This study is testing if getting an implantable defibrillator helps people with coronary artery disease who have survived a cardiac arrest feel better and live longer.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT04576130

• Registry for Abbott vascular medical devices

  This study is collecting information on Abbott vascular medical devices to see how safe and effective they are for patients who have had procedures using these devices.

  Recruiting at 34 sites Abbott Medical Devices · Birmingham, Alabama and 36 other locations · NCT04573660

• Understanding new-onset atrial fibrillation in patients with heart attacks

  This study is trying to see how new-onset atrial fibrillation affects heart attack patients and if it can help guide their treatment after they leave the hospital.

  Recruiting at 5 sites Shanghai 10th People's Hospital · Kaifeng, Henan and 4 other locations · NCT04528511

• Using VA-ECMO to treat cardiogenic shock in heart attack patients

  This study is testing if using a special heart support machine along with another device can help heart attack patients in severe shock feel better compared to just standard treatment.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04184635

• Evaluation of patient outcomes after acute myocardial infarction in France

  This study looks at how patients in France do after having a heart attack by collecting information on their care and recovery from hospitals and national health records.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04050956

• Treating severe gum disease to reduce inflammation in heart attack patients

  This study is testing if treating severe gum disease can help reduce inflammation in heart attack patients' arteries and improve their heart health.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04046237

• Education tailored to your health literacy to help follow heart-care instructions after a heart attack or heart failure

  This trial tests whether an educational toolkit adapted for people with limited health literacy helps patients hospitalized for a heart attack or worsening heart failure follow medical recommendations and avoid readmission.

  Recruiting at 4 sites Hospices Civils de Lyon · Bron and 3 other locations · NCT03951467

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeted nanotherapy to calm inflammation, grow new blood vessels, and prevent scarring after a heart attack

  A new treatment approach uses engineered secretions from immune cells delivered early after a heart attack to reduce inflammation, promote blood vessel growth, and limit scarring to protect heart function.

  NIH research Washington University · Saint Louis, United States · NIH-11432693

• Real-time multi-lead ECG from wearables to help detect heart attacks early

  A new AI-based approach uses everyday wearable sensors to turn simple PPG signals into multi-lead ECG data to monitor for heart attacks in real time, even outside the clinic.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11417336

• Extreme heat and heart attack risk: who is most at risk and why

  High heat and air pollution may raise the risk of heart attacks, and this project looks at who is most affected.

  NIH research Yale University · New Haven, United States · NIH-11408435

• MMP-responsive biomaterials to treat a heart attack

  A heart-attack treatment using smart materials that release healing therapies right where the heart was damaged, aimed at people who’ve had a heart attack.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11394332

• Nanoparticle therapy to reduce inflammation and scarring after a heart attack

  Tiny engineered nanoparticles will deliver anti-inflammatory and anti-scarring substances to the heart soon after a heart attack to help people recover better.

  NIH research Washington University · Saint Louis, United States · NIH-11264911

• Using ultrasound images and AI to better describe and predict heart attacks

  This project uses routine heart ultrasound images plus AI to create detailed profiles that help predict outcomes for people hospitalized with acute heart attacks.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11247576

• Investigating how LRP1 signaling affects heart cells during heart attacks

  This study is looking at how a special protein in heart cells, called LRP1, works during a heart attack, and it aims to find new ways to help patients recover better by using tiny targeted treatments that could protect the heart and reduce damage.

  NIH research University of Virginia · Charlottesville, United States · NIH-11167804

• Heart-repair materials that activate after a heart attack

  Injectable, enzyme-activated materials designed to be delivered by catheter to help the heart heal after an acute myocardial infarction.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11138668

• Extreme heat, air pollution, and heart attack risk: who is most vulnerable

  This project looks at whether very hot weather, humidity, temperature swings, and air pollution make heart attacks more likely for younger and older adults and whether sex, medical history, socioeconomic status, or common heart medications change that risk.

  NIH research Yale University · New Haven, United States · NIH-11138632

• Using advanced imaging and AI to improve heart attack risk assessment

  This study is looking at how advanced heart imaging and smart computer technology can help doctors better understand which heart attack patients are at the highest risk, so they can create more personalized treatment plans to improve their health.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11067568

• Using engineered nanoparticles to reduce inflammation and scarring after heart attacks

  This study is exploring a new way to help your heart heal after a heart attack by using tiny particles to deliver medicine that reduces inflammation right where it's needed, which could improve your recovery and heart function.

  NIH research Washington University · Saint Louis, United States · NIH-11063270

• How extreme heat and air pollution affect heart attacks in different people

  This study is looking at how really hot weather and air pollution might lead to heart attacks, especially in different groups of people like young adults, older adults, and women, to see if things like gender, income, and health history make a difference in their risk.

  NIH research Yale University · New Haven, United States · NIH-10919813

• Understanding frailty and recovery in older adults after heart attacks

  This study is looking at older adults who have had a heart attack to create an easy test that helps understand their strength and ability to recover, with the hope of finding better ways to care for them and improve their health outcomes.

  NIH research Inova Health Care Services · Fairfax, UNITED STATES · NIH-10893043

• Exploring new ways to protect the heart during severe heart attacks using advanced life support.

  This study is looking at how a special heart support system called VA-ECMO can help protect the heart from damage during a severe heart attack, and it's designed for people who want to understand new ways to improve heart care in these situations.

  NIH research Tufts Medical Center · Boston, United States · NIH-10889046

• Improving outcomes for older adults after heart attacks

  This study is looking at how to help older adults, especially those 75 and up, recover better after a heart attack by understanding their specific challenges and finding ways to improve their care after leaving the hospital.

  NIH research Yale University · New Haven, United States · NIH-10794248

• Identifying proteins linked to heart disease recurrence in heart attack survivors

  This study is looking at why some people have repeated heart problems after a heart attack by checking proteins in their blood, and it hopes to find new ways to help prevent future heart issues for those who have survived a heart attack.

  NIH research University of Washington · Seattle, United States · NIH-10676123

Related topics

Quick answers

How many Acute Myocardial Infarction clinical trials are recruiting right now?

30, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in China (8 trials), France (6 trials), United States (4 trials), South Korea (4 trials), Denmark (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 7. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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