Optimizing Impella 5.5 Outcomes With Advanced Data Science

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational work links high-resolution Impella 5.5 pump data with ICU electronic health records to build a clinical decision support tool. It validates pump placement signals against arterial waveforms and analyzes how device metrics relate to native heart recovery, need for heart replacement therapy, and mortality while on support. The project also aims to identify patterns associated with hemolysis, hemorrhagic risk events, and arrhythmias to develop predictive approaches that could mitigate these issues. Data management includes time-series alignment, data preprocessing, and retrospective longitudinal analysis to support future decisions in cardiogenic shock care. The study is conducted at the Medical University of Vienna using real-world data from adult patients treated with Impella 5.5 for cardiogenic shock.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients who were treated for cardiogenic shock and supported with an Impella 5.5 micro-axial flow pump
* Only patients with available high-resolution pump data (downloaded from the clinical console) and ICU digital health record datasets

Exclusion Criteria:

* Patients supported with an Impella 5.5 for indications other than cardiogenic shock (e.g., protected PCI or CABG)
* Patients younger than 18 years
* Patients with incomplete data, procedural records, or demographic information

Where it's running

• Medical University of Vienna
  Vienna, Austria Recruiting

Study contacts

• Principal investigator: Thomas Schlöglhofer, PhD, MSc — Medical University of Vienna
• Study coordinator: Thomas Schlöglhofer, PhD, MSc
• Email: thomas.schloeglhofer@meduniwien.ac.at
• Phone: +4314040027280

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cardiogenic Shock Outcomes Registry (COR-SHOCK): how patients fare over time

  This observational registry tests how outcomes and management of cardiogenic shock have changed over the years in adults receiving routine care.

  Recruiting Hospital de Santa Cruz, Portugal · Carnaxide, Lisbon District · NCT07597291

• Outcomes in patients with mixed cardiogenic and vasoplegic shock

  This registry will try to describe outcomes and risk factors in adults admitted with cardiogenic shock who also have inappropriate vasodilation (mixed cardiogenic‑vasoplegic shock).

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Somme · NCT07354568

• Factors Influencing Outcomes in ECMO and Impella Patients

  This study tests whether metabolic and thyroid hormone changes help predict survival for adults on ECMO or Impella at a single Hungarian cardiac ICU.

  Recruiting Gottsegen National Cardiovascular Institute · Budapest · NCT07885618

• Evaluating a noninvasive tissue sensor to detect cardiogenic shock earlier in heart patients

  This pilot, noninvasive study tests whether the NIRSense wearable can help detect deterioration in adults with cardiogenic shock risk due to heart attack or heart failure.

  Recruiting NIRSense Inc. · Weston, Florida · NCT07825363

• Safety and Efficacy of an Extracorporeal Ventricular Assist System for Cardiogenic Shock

  This study tests whether an extracorporeal ventricular assist device can safely provide short-term heart support and help patients with cardiogenic shock or trouble weaning from bypass.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07769528

• Left Ventricular Support and Advanced Monitoring in AMI–Cardiogenic Shock: Immediate Impella Use and PAC/Monitoring vs Standard Care

  In adults with heart attack-related cardiogenic shock, this trial tests whether using an Impella left ventricular assist device and/or protocolized pulmonary artery catheter monitoring improves survival compared with standard care.

  Recruiting Leipzig Heart Science gGmbH · Leipzig, Saxony · NCT07762560

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.