Hemodynamic resuscitation with a Swan-Ganz catheter in cardiogenic shock.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, non-randomized interventional protocol enrolls adults with cardiogenic shock secondary to acute myocardial infarction and uses a Swan‑Ganz pulmonary artery catheter to guide goal-directed hemodynamic optimization. The catheter provides continuous pressures, thermodilution cardiac output, and mixed venous oxygen saturation, recorded at baseline and predefined early intervals (0, 3, 6, 9, 12, 24 hours) to steer therapy. Treatments are titrated to predefined hemodynamic targets—cardiac index ≥2.2 L/min/m², mean arterial pressure ≥65 mmHg, PCWP 12–18 mmHg, CVP 8–12 mmHg, SvO₂ >60–80%, and lactate <2 mmol/L—through adjustments in inotropes, vasopressors, and fluids. The primary endpoint is 30‑day all‑cause mortality with in-hospital mortality and duration of vasoactive support among the secondary outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years.
* Provided written informed consent to participate in the study.
* Diagnosed with cardiogenic shock due to acute myocardial infarction according to IABP-SHOCK II (2012) criteria:

  * Systolic blood pressure (SBP) \< 90 mmHg for at least 30 minutes, or requiring vasopressor agents to maintain SBP \> 90 mmHg.
  * Evidence of end-organ hypoperfusion, indicated by at least one of the following: Altered mental status, Urine output \< 30 mL/hour, Cold extremities with mottled skin, Serum lactate level \> 2 mmol/L.

Exclusion Criteria:

* Presence of cervical cellulitis.
* Inability to identify neck anatomy or history of cervical radiotherapy.
* Coagulopathy (INR \> 1.5 and/or platelet count \< 50 G/L).
* End-stage chronic diseases, including: Advanced malignancy, advanced-stage HIV, bedridden patients for more than 3 months, decompensated liver cirrhosis (Child-Pugh class C).
* Patients with cardiac arrest or mechanical complications such as myocardial rupture prior to Swan-Ganz catheterization.
* Congenital heart defects or intracardiac shunts. Refusal of participation by the patient or their legal representative.

Where it's running

• BachMai Hospital, Hanoi Medical University
  Hanoi, Vietnam Recruiting

Study contacts

• Principal investigator: Thang Xuan Pham, MD, PhD Candidate — Hanoi Medical University
• Study coordinator: Thang Xuan Pham, MD, PhD Candidate
• Email: pxthanghmu92@gmail.com
• Phone: +84357991992

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.