On-scene extracorporeal CPR (ECPR) in Ostrava
The Effectiveness of ECPR on the Scene and in Hospital for Out-of-hospital Cardi-ac Arrest (OHCA) in the Moravian-Silesian Region.
This tests doing ECMO (ECPR) at the scene for people ≤70 with witnessed out-of-hospital cardiac arrest who received bystander CPR to see if starting ECMO faster helps them survive with good brain function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | University Hospital Ostrava Academic / other |
| Locations | 2 sites (Ostrava, Moravian-Silesian Region and 1 other locations) |
| Trial ID | NCT07374289 on ClinicalTrials.gov |
What this trial studies
This interventional program compares performing ECMO cannulation directly at the collapse scene by a mobile team versus transporting patients under mechanical chest compression for hospital cannulation. Eligible patients have a presumed cardiac cause, witnessed collapse, and bystander CPR, and teams aim to shorten the collapse-to-ECMO interval. The primary goal is to measure how much on-scene cannulation shortens the time from collapse to ECMO start; secondary outcomes compare survival and neurological status between the two approaches. The mobile ECPR effort is carried out by University Hospital Ostrava in collaboration with the regional emergency medical service.
Who should consider this trial
Good fit: Ideal candidates are people 70 years or younger with a presumed cardiac out-of-hospital arrest that was witnessed and who received immediate bystander CPR.
Not a fit: Patients with terminal malignant or chronic disease, unwitnessed arrests, no bystander CPR, likely non-cardiac causes, or older than 70 are unlikely to benefit from this approach.
Why it matters
Potential benefit: If successful, on-scene ECPR could substantially shorten time to ECMO and increase survival with good neurological outcomes in selected patients.
How similar studies have performed: Other ECPR programs have shown improved survival with good neurological outcomes in selected patients, but mobile on-scene ECPR is newer and less extensively studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presumed cardiac aetiology of the cardiac arrest * Witnessed collapse * Bystander CPR * Estimated age ≤ 70 years * Body weight ≥15 Kg Exclusion Criteria: * Known terminal malignant disease * Known terminal chronic disease
Where this trial is running
Ostrava, Moravian-Silesian Region and 1 other locations
- Emergency Medical Services, Moravian-Silesian Region — Ostrava, Moravian-Silesian Region, Czechia (Recruiting)
- University Hospital Ostrava — Ostrava, Moravian-Silesian Region, Czechia (Recruiting)
Study contacts
- Principal investigator: Filip Burša, MD, PhD, EDEC — University Hospital Ostrava
- Study coordinator: Jiří Hynčica
- Email: jiri.hyncica@fno.cz
- Phone: +42059737
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.