Natural history of type I interferonopathies in a European patient group

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter observational cohort collecting clinical, genetic, and laboratory data from patients with genetically confirmed type I interferonopathies across European sites. Investigators will record neurological, joint, and hematological features and measure the interferon-stimulated gene expression ('interferon signature') over time. No investigational drugs are given; instead the study aims to define the natural history, identify biomarkers for diagnosis and prognosis, and inform endpoints for future trials. Data will be used to better understand variability in onset, progression, and response to standard supportive treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Genetically confirmed patient with type I interferonopathy
* Patient affiliated to a social security scheme or beneficiary of such a scheme.

Exclusion Criteria:

\- Opposition of the patient and/or parental authority if the patient is a minor, to participation in the study.

Where it's running

• Motol University Hospital
  Prague, Czechia Recruiting
• CHU d'Angers
  Angers, France Recruiting
• Hôpital de Mercy - CHR Metz Thionville
  Ars-Laquenexy, France Recruiting
• CHU de Besançon
  Besançon, France Recruiting
• CHU Morvan
  Brest, France Recruiting
• Hôpital Femme Mère Enfant - HCL
  Bron, France Recruiting

Study contacts

• Study coordinator: Marie-Louise FREMOND, Pr
• Email: marie-louise.fremond@institutimagine.org
• Phone: 01 44 49 48 24

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.