Condition

Sjogren's Syndrome clinical trials and research

• 23Clinical trials
• 17NIH research projects
• 9Countries

Newest Sjogren's Syndrome clinical trials

All recruiting trials (23)

• Pain patterns in rheumatic diseases: see if pain works differently in patients and healthy people

  This observational study tests how pain is experienced and measured in people with rheumatic diseases compared with healthy volunteers.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07829497

• First-in-human test of CND319 in healthy people and people with rheumatic diseases

  This early study tests whether CND319 is safe and tolerable and whether it shows any signs of activity in healthy adults and in people with rheumatoid arthritis or Sjogren's syndrome.

  Recruiting Phase 1 Candid Therapeutics · Melbourne, Victoria · NCT07712939

• Tofacitinib safety for people with primary Sjogren disease

  This study will test whether the oral pill tofacitinib is safe and tolerable for adults with primary Sjogren disease and mild-to-moderate symptoms.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07281456

• YTS109 cell therapy for relapsed or refractory autoimmune diseases

  This will try a single infusion of YTS109 immune cells to see if they are safe and help adults 18–65 with relapsed or refractory lupus (including lupus nephritis), Sjogren's syndrome, inflammatory myopathy, or ANCA‑associated vasculitis.

  Recruiting Phase 1 China Immunotech (Beijing) Biotechnology Co., Ltd. · Bengbu · NCT07236762

• Creating Health online course for people with rheumatological conditions

  This project will test whether an online course about diet and self-care helps adults with rheumatoid arthritis, Sjogren's syndrome, lupus, mixed connective tissue disease, or psoriatic arthritis reduce fatigue and improve quality of life.

  Recruiting University of Iowa · Iowa City, Iowa · NCT07180537

• 68Ga-FAPI PET-CT to image inflammation in Sjögren's syndrome

  This trial will test whether 68Ga-FAPI PET-CT can show active inflammation in adults with Sjögren's syndrome compared with tumor patients.

  Recruiting Phase 1/2 Peking Union Medical College Hospital · Beijing · NCT07062523

• CLN-978 injections for people with moderate to severe Sjögren's disease

  This trial will try subcutaneous injections of CLN-978, a CD19-directed T cell engager, in adults with active moderate-to-severe Sjögren's disease to see if it reduces disease activity.

  Recruiting at 14 sites Phase 1 Cullinan Therapeutics Inc. · Orlando, Florida and 13 other locations · NCT07041099

• Effects of phytocannabinoids on immune response in chronic inflammatory diseases

  This study is testing whether phytocannabinoids like CBD and THC can help improve the immune response in people with chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans · NCT06842316

• Analyzing exosomes to understand Sjogren's and dry eye syndromes

  This study is trying to see if looking at tiny particles in the body can help us understand Sjogren's Syndrome and Dry Eye Syndrome better, while also testing acupuncture and herbal tea as possible treatments for these conditions.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei, Taiwan · NCT06771427

• Targeted CAR-T therapy for autoimmune diseases

  This study is testing a new type of CAR-T therapy to see if it can help people with active autoimmune diseases feel better and manage their symptoms.

  Recruiting Early Phase 1 Nanjing Bioheng Biotech Co., Ltd. · Bengbu, Anhui · NCT06548607

• CAR-T cell therapy targeting specific markers in autoimmune diseases

  This study is testing a new CAR-T cell therapy to see if it can help people with tough autoimmune diseases like lupus and Sjogren's syndrome feel better.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT06428188

• Using belimumab after rituximab for treating resistant juvenile Sjogren's syndrome

  This study is testing if giving belimumab after rituximab can help children aged 5-18 with tough-to-treat juvenile Sjogren's syndrome feel better.

  Recruiting Phase 4 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06410833

• YTS109 cell injection for autoimmune diseases

  This study is testing if YTS109 cell injections can help people with stubborn autoimmune diseases feel better and improve their health.

  Recruiting China Immunotech (Beijing) Biotechnology Co., Ltd. · Shanghai, Shanghai Municipality · NCT06379646

• Study on how diet affects autoimmune diseases in rheumatology patients

  This study looks at how changing to a healthier diet, like the Mediterranean diet, might help people with autoimmune diseases feel better and manage their symptoms.

  Recruiting University of Central Florida · Orlando, Florida · NCT06339957

• Using ultra-high frequency ultrasound to diagnose Sjögren's syndrome

  This study is testing if a new type of ultrasound can help doctors diagnose Sjögren's syndrome more accurately by looking at the small salivary glands in addition to the bigger ones.

  Recruiting University of Pisa · Pisa · NCT06338735

• Assessing how patient feedback affects treatment adjustments for autoimmune diseases

  This study is testing if regular feedback from patients with autoimmune diseases like gout and rheumatoid arthritis can help doctors make better treatment decisions and improve patient care.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT05927688

• Nationwide registry for systemic autoimmune and autoinflammatory diseases in Armenia

  This study is trying to gather information about systemic autoimmune and autoinflammatory diseases in Armenia to better understand how these conditions progress and how they are treated.

  Recruiting at 4 sites Santé Arménie French-Armenian Research Center · Yerevan and 5 other locations · NCT05904301

• Cohort of patients with suspected primary Sjögren syndrome

  This study is testing different ways to diagnose primary Sjögren syndrome in patients who might have it, by comparing results from various tests to expert opinions over a long period of time.

  Recruiting University Hospital, Brest · Brest · NCT04931160

• Registry and biorepository for rheumatic diseases

  This study is collecting samples and health information from adults with rheumatic diseases at Yale clinics to help researchers learn more about these conditions and improve future treatments.

  Recruiting Yale University · New Haven, Connecticut · NCT04402086

• Collection of samples from patients with rheumatic diseases

  This study is collecting samples from people with rheumatic diseases to help researchers learn more about these conditions and improve treatments in the future.

  Recruiting Meir Medical Center · Kfar Saba · NCT03473912

• Registry for pregnant women with autoimmune diseases

  This study is trying to learn more about how autoimmune diseases affect pregnant women and their babies to help improve their health during and after pregnancy.

  Recruiting Duke University · Durham, North Carolina · NCT03276923

• Understanding diseases that affect salivary glands

  This study is trying to learn more about diseases that affect salivary glands, like Sjogren's Syndrome, by collecting information and samples from people with these conditions and healthy volunteers.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02327884

• Understanding Sjogren's Disease and its Effects

  This study is trying to learn more about Sjogren's Disease and how it affects people, by looking at their symptoms and health history.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01425892

NIH-funded research (17)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Glycolytic metabolites, Calcium entry, and Sjögren’s syndrome

  A patient-focused look at how tiny changes in metabolism and calcium signaling might contribute to Sjögren’s syndrome and its effects on saliva.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11359626

• How aging and cell stress damage salivary glands in Sjögren’s

  Researchers are testing whether getting older and increased oxidative (cell) stress make salivary glands more likely to be damaged in Sjögren’s, using mouse models that mimic the disease.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11296942

• Protein-polymer treatment for Sjögren's

  This project creates tiny protein-polymer medicines intended to reduce eye and mouth dryness and inflammation for people with Sjögren's syndrome.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11251228

• Understanding Sjogren's Syndrome and Saliva Production

  This research explores how natural body chemicals and calcium affect saliva production and immune cells in people with Sjögren's syndrome.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11110346

• Developing a new treatment for dry eye disease caused by Sjogren's syndrome

  This study is testing a new, easy-to-get treatment for dry eyes caused by Sjogren's syndrome, using special cells to create a healing extract that could help improve your symptoms and overall eye health.

  NIH research Stellular Bio, INC. · Watertown, United States · NIH-11067525

• Improving saliva and tear production in Sjögren's syndrome

  This study is looking at how blocking certain receptors in the glands that produce saliva and tears might help people with Sjögren's syndrome, a condition that causes dry mouth and dry eyes, by improving their gland function and making them feel better.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11041086

• Investigating the role of LINE1 and IFI16 in Sjögren's syndrome

  This study is looking at how a specific part of our DNA interacts with the immune system in people with Sjögren's syndrome, which could help us understand the disease better and find new ways to treat it.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11036271

• How aging and oxidative stress affect salivary gland disease in Sjögren’s Syndrome

  This study is looking at how getting older and stress in the body might affect the salivary glands in people with Sjögren’s Syndrome, with the hope of finding better ways to treat and manage the condition.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11013397

• Identifying genetic factors that increase the risk of Sjögren's syndrome

  This study is looking at the genes that might play a role in Sjögren's syndrome, a condition that causes dryness and fatigue, to help find better treatments for people living with it.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-10907847

• Investigating how glycolytic metabolites and calcium entry affect Sjögren's syndrome

  This study is looking at how certain substances in the body, like lactate, affect immune cells in people with Primary Sjögren's syndrome, which can cause dry mouth and other issues, to find new ways to help improve salivary gland function.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-10855763

• Investigating the role of autoantibodies in Sjögren's syndrome

  This study is looking at how certain immune cells in the salivary glands of people with Sjögren's syndrome create antibodies that might make dry mouth and dry eyes worse, with the hope of finding new ways to help manage the condition.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-10854472

• Finding ways to reduce inflammation and help salivary glands heal in Sjogren's syndrome

  This study is looking at how special substances can help heal the salivary glands in people with Sjogren's syndrome, aiming to improve dry mouth and overall health.

  NIH research Ada Forsyth Institute, INC. · Cambridge, United States · NIH-10657745

• A new probiotic treatment for Sjögren's Syndrome

  This study is testing a new probiotic treatment to help people with Sjögren's Syndrome feel better by boosting their immune system, and it could be taken as a drink to improve daily life.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-10615156

• Understanding T cell interactions in Sjogren’s syndrome and exploring genetic treatments

  This study is looking at how certain T cell receptors might play a role in Sjogren’s syndrome, which causes dry mouth and dry eyes, to help find new treatments for people dealing with this condition.

  NIH research University of Florida · Gainesville, United States · NIH-10599844

• Investigating the role of the immune system in dry eye disease linked to Sjögren's syndrome

  This study is looking at how the immune system affects dry eye disease in people with Primary Sjögren's syndrome, with the goal of finding new ways to identify and treat this condition to help improve eye health and comfort.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10561638

• Understanding the immune cells involved in Sjögren's syndrome

  This study is looking at certain immune cells in people with Sjögren's syndrome to understand what triggers the immune response, which could help find new ways to treat the condition.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-10469419

• Investigating mitochondrial RNA in pediatric Sjogren's syndrome

  This study is looking at a rare type of Sjogren's syndrome in kids and teens to help tell it apart from other similar conditions, and it will explore how their immune systems work to better understand this autoimmune disease.

  NIH research University of Florida · Gainesville, United States · NIH-10287866

Related topics

Quick answers

How many Sjogren's Syndrome clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (9 trials), China (6 trials), France (4 trials), Italy (2 trials), Israel (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 1/2: 2, Early Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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