Mapping immune cells and tissue changes in autoimmune diseases
Official title: Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC)
Funded at Brigham and Women's Hospital · NIH-11286638 · Data updated 2026-11-12
Using advanced lab methods to identify the immune cell types and molecular signals driving conditions like rheumatoid arthritis, lupus, psoriatic diseases, and Sjögren's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 18, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $1,098,803 |
| NIH project number | 5UC2AR081023-05 |
| Project ID | NIH-11286638 on NIH RePORTER |
Who could benefit from this research
✓Could help
People diagnosed with rheumatoid arthritis, systemic lupus erythematosus, psoriatic spectrum diseases, Sjögren's syndrome, or related autoimmune/inflammatory conditions who can provide blood or tissue samples are ideal candidates.
✕Less likely to help
Healthy volunteers or people without autoimmune or inflammatory conditions are unlikely to receive direct benefit, and participants should not expect immediate treatment changes from taking part.
What this research studies
This project analyzes blood and tissue samples from people with autoimmune diseases using high‑resolution lab tests such as single‑cell and spatial molecular profiling. The team will combine many types of data to map which cells, proteins, and genes are active in inflamed tissues. By comparing samples across diseases and subtypes, they aim to find shared and disease‑specific cell states and pathways. The Systems Biology Core will build the data and analysis tools so researchers can better understand how inflammation causes damage.
Why it matters
Potential benefit: If successful, this work could reveal new targets and markers that lead to more precise diagnoses and better, more personalized treatments for autoimmune disease patients.
How similar studies have gone: Prior AMP RA/SLE work successfully identified key cell states in inflamed RA synovium and SLE kidneys, so this project builds on proven methods while expanding to more diseases and data types.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Raychaudhuri, Soumya — Brigham and Women's Hospital
- Study coordinator: Raychaudhuri, Soumya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.