Understanding B cell Roles in autoimmune diseases like lupus
Official title: Regulation of B cell Responses in SLE and Other Autoimmune Diseases
Funded at Emory University · NIH-11332680 · Data updated 2026-11-12
Doctors are studying how B cells go wrong in autoimmune diseases to develop better, more precise treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 1, 2014 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $4,279,748 |
| NIH project number | 5U19AI110483-13 |
| Project ID | NIH-11332680 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with autoimmune diseases, including SLE, with well-characterized disease features and consent to provide samples and data.
✕Less likely to help
Patients not aligned with the study’s specific autoimmune profiles or without access to the participating centers may not directly benefit.
What this research studies
This grant focuses on mapping how B cells behave in autoimmune diseases such as SLE by examining their molecular programs at the single-cell level. It creates a collaborative platform to study B cells and other immune cells across multiple centers and patient populations. The goal is to translate these insights into targeted therapies that address the specific B cell dysregulation seen in different patients. The project emphasizes integrating clinicians, researchers, and patient samples to build a mechanistic understanding of autoimmune responses.
Why it matters
Potential benefit: If successful, patients could receive more tailored therapies that target the root causes of their autoimmune B cell abnormalities.
How similar studies have gone: Prior studies using single-cell analyses have shown meaningful insights into B cell roles in autoimmunity, supporting this approach.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Sanz, Ignacio E. — Emory University
- Study coordinator: Sanz, Ignacio E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.