Clinical trial Recruiting at 1 site Phase1; Phase2 Interventional Ages 18 and up

Using stem cells to treat various chronic and acute health conditions

Official title: Evaluation of the Safety, Tolerability and Efficacy of Regenerative Therapy for the Treatment of Various Chronic and Acute Conditions

Run by Thomas Advanced Medical LLC · NCT04684602 · Data updated 2026-11-12

This study is testing if stem cell therapy can help people with different long-term and short-term health issues, like autoimmune diseases and heart problems, feel better and improve their quality of life.

More Autoimmune Diseases trials

Quick facts

PhasePhase1; Phase2
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment5000 (estimated)
SponsorThomas Advanced Medical LLC
Industry-sponsored
Locations1 site (Culver City, California)
StatusRecruiting
StartedJuly 9, 2020
Main results expectedJuly 9, 2030
Study endsDecember 9, 2030
Registry record updatedApril 29, 2022
Trial IDNCT04684602 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who can provide informed consent and are available for follow-up visits.

Probably not a fit

Patients with active or recent malignancy, those who are pregnant or breastfeeding, or individuals unable to provide informed consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multi-arm, multi-site study evaluates the safety, tolerability, and efficacy of stem cell therapy for a range of acute and chronic conditions, including autoimmune diseases, cardiovascular disorders, and diabetes complications. The study is designed to gather clinical outcomes using various validated instruments that assess both general quality of life and condition-specific metrics. Participants will receive treatments with PrimePro™ or PrimeMSK™ stem cell therapies, with follow-up visits to monitor their progress and response to treatment.

Why it matters

Potential benefit: If successful, this study could provide new treatment options for patients suffering from a variety of chronic and acute conditions.

How similar studies have gone: Other studies have shown promising results with stem cell therapies for various conditions, indicating potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18 and older
* Ability to provide informed consent
* Availability for follow up visits

Exclusion Criteria:

* Active or recent malignancy (within last 2 years)
* Pregnancy or breast-feeding
* Inability to provide informed consent

Where it's running

  • Southern California Hospital at Culver City / Southern California Hospital at Hollywood / Multiple US-based Sub-Investigator Sites
    Culver City, California, United States
    Recruiting

Study contacts

  • Principal investigator: Ernst R Von Schwarz, MD, PhD — HeartStem Institute, Southern California Hospital at Culver City
  • Study coordinator: Paul C Bogaardt, PhD(c), MSc, MBA
  • Email: paul@thomasadvancedmedical.com
  • Phone: 866 864 7789

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.