Analyzing single cells and tissues from patients with autoimmune diseases
Official title: Single cell and spatial genomic analyses of specimens from patients with autoimmune diseases (Technology Core)
Funded at Brigham and Women's Hospital · NIH-11015810 · Data updated 2026-11-12
This study is looking at how autoimmune diseases like rheumatoid arthritis, psoriasis, and lupus affect the body by examining blood and tissue samples from patients, with the goal of finding new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 22, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $300,000 |
| NIH project number | 5UC2AR081031-04 |
| Project ID | NIH-11015810 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autoimmune diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, primary Sjögren’s syndrome, or systemic lupus erythematosus.
✕Less likely to help
Patients without autoimmune diseases or those with conditions not included in the study may not benefit from this research.
What this research studies
This research investigates the molecular and cellular mechanisms behind autoimmune diseases by analyzing biological samples from patients with conditions such as rheumatoid arthritis, psoriasis, and systemic lupus erythematosus. The team will utilize advanced technologies to profile tissues and blood samples, focusing on understanding how these diseases affect the body at a cellular level. Collaborating with a network of clinicians and biologists, the project aims to optimize methods for preserving and analyzing these samples to gain insights into disease pathways. This comprehensive approach will help identify potential targets for new treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with autoimmune diseases.
How similar studies have gone: Other research has shown success in using advanced genomic profiling techniques to understand autoimmune diseases, indicating that this approach is promising.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Brenner, Michael B. — Brigham and Women's Hospital
- Study coordinator: Brenner, Michael B.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.