Examining STIM1 Protein Levels in Autoimmune Disease Patients
Official title: Study of STIM1 Membrane Expression During Autoimmune Diseases
Run by University Hospital, Brest · NCT04978948 · Data updated 2026-11-12
This study is testing the levels of a protein called STIM1 in blood cells from people with autoimmune diseases to see if it could help understand these conditions better.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 670 (estimated) |
| Sponsor | University Hospital, Brest Academic / other |
| Drugs / interventions | rituximab |
| Locations | 4 sites (Brest, Brest and 3 other locations) |
| Status | Recruiting |
| Started | May 11, 2021 |
| Main results expected | May 2027 |
| Study ends | May 2027 |
| Registry record updated | June 26, 2026 |
| Trial ID | NCT04978948 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with autoimmune diseases.
✕Probably not a fit
Patients who have received rituximab treatment in the past 12 months will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the expression of STIM1 in the plasma membrane of lymphocytes from patients diagnosed with various autoimmune diseases. By identifying the levels of STIM1, researchers hope to uncover new pathologies that exhibit an over-expression of this protein. The findings could pave the way for future research and development of anti-STIM1 antibodies targeted at these autoimmune conditions. The study will involve patients from multiple hospital locations in Brittany and Martinique.
Why it matters
Potential benefit: If successful, this study could lead to new therapeutic options for patients with autoimmune diseases through the development of targeted anti-STIM1 treatments.
How similar studies have gone: While this approach is novel in the context of STIM1 expression in autoimmune diseases, similar studies targeting specific proteins have shown promise in other conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of one of the autoimmune diseases Exclusion Criteria: * Treatment with rituximab in the previous 12 months
Where it's running
-
CHRU de Brest - Service de rhumatologie
Brest, Brest, France Recruiting -
Centre Hospitalier des Pays de Morlaix
Morlaix, Brittany Region, France Recruiting -
Centre Hospitalier de Quimper
Quimper, Brittany Region, France Recruiting -
CHU de Martinique
Fort-de-France, Martinique, France Recruiting
Study contacts
- Study coordinator: Divi Cornec
- Email: divi.cornec@chu-brest.fr
- Phone: 02 98 22 33 33
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.