Clinical trial Recruiting at 4 sites Observational Ages 18 to 99

Examining STIM1 Protein Levels in Autoimmune Disease Patients

Official title: Study of STIM1 Membrane Expression During Autoimmune Diseases

Run by University Hospital, Brest · NCT04978948 · Data updated 2026-11-12

This study is testing the levels of a protein called STIM1 in blood cells from people with autoimmune diseases to see if it could help understand these conditions better.

More Autoimmune Diseases trials

Quick facts

Study typeObservational
Ages18 Years to 99 Years
SexAll
Enrollment670 (estimated)
SponsorUniversity Hospital, Brest
Academic / other
Drugs / interventionsrituximab
Locations4 sites (Brest, Brest and 3 other locations)
StatusRecruiting
StartedMay 11, 2021
Main results expectedMay 2027
Study endsMay 2027
Registry record updatedJune 26, 2026
Trial IDNCT04978948 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals diagnosed with autoimmune diseases.

Probably not a fit

Patients who have received rituximab treatment in the past 12 months will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the expression of STIM1 in the plasma membrane of lymphocytes from patients diagnosed with various autoimmune diseases. By identifying the levels of STIM1, researchers hope to uncover new pathologies that exhibit an over-expression of this protein. The findings could pave the way for future research and development of anti-STIM1 antibodies targeted at these autoimmune conditions. The study will involve patients from multiple hospital locations in Brittany and Martinique.

Why it matters

Potential benefit: If successful, this study could lead to new therapeutic options for patients with autoimmune diseases through the development of targeted anti-STIM1 treatments.

How similar studies have gone: While this approach is novel in the context of STIM1 expression in autoimmune diseases, similar studies targeting specific proteins have shown promise in other conditions.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of one of the autoimmune diseases

Exclusion Criteria:

* Treatment with rituximab in the previous 12 months

Where it's running

  • CHRU de Brest - Service de rhumatologie
    Brest, Brest, France
    Recruiting
  • Centre Hospitalier des Pays de Morlaix
    Morlaix, Brittany Region, France
    Recruiting
  • Centre Hospitalier de Quimper
    Quimper, Brittany Region, France
    Recruiting
  • CHU de Martinique
    Fort-de-France, Martinique, France
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.