Examining STIM1 Protein Levels in Autoimmune Disease Patients
Study of STIM1 Membrane Expression During Autoimmune Diseases
This study is testing the levels of a protein called STIM1 in blood cells from people with autoimmune diseases to see if it could help understand these conditions better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 670 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | University Hospital, Brest Academic / other |
| Drugs / interventions | rituximab |
| Locations | 4 sites (Brest, Brest and 3 other locations) |
| Trial ID | NCT04978948 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the expression of STIM1 in the plasma membrane of lymphocytes from patients diagnosed with various autoimmune diseases. By identifying the levels of STIM1, researchers hope to uncover new pathologies that exhibit an over-expression of this protein. The findings could pave the way for future research and development of anti-STIM1 antibodies targeted at these autoimmune conditions. The study will involve patients from multiple hospital locations in Brittany and Martinique.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with autoimmune diseases.
Not a fit: Patients who have received rituximab treatment in the past 12 months will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new therapeutic options for patients with autoimmune diseases through the development of targeted anti-STIM1 treatments.
How similar studies have performed: While this approach is novel in the context of STIM1 expression in autoimmune diseases, similar studies targeting specific proteins have shown promise in other conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of one of the autoimmune diseases Exclusion Criteria: * Treatment with rituximab in the previous 12 months
Where this trial is running
Brest, Brest and 3 other locations
- CHRU de Brest - Service de rhumatologie — Brest, Brest, France (Recruiting)
- Centre Hospitalier des Pays de Morlaix — Morlaix, Brittany Region, France (Recruiting)
- Centre Hospitalier de Quimper — Quimper, Brittany Region, France (Recruiting)
- CHU de Martinique — Fort-de-France, Martinique, France (Recruiting)
Study contacts
- Study coordinator: Divi Cornec
- Email: divi.cornec@chu-brest.fr
- Phone: 02 98 22 33 33
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.