Clinical trial Recruiting at 1 site Interventional Ages 18 to 80

Music-4-MS: A 12-week music-based program to support thinking skills in people with MS

Official title: A Randomized Controlled Trial of Music-4-MS Compared to Music Listening to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study

Run by University of Texas at Austin · NCT07759115 · Data updated 2026-11-12

A 12-week music-based program is tested to see if it helps cognitive function and mood in people living with multiple sclerosis.

Quick facts

Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment64 (estimated)
SponsorUniversity of Texas at Austin
Academic / other
Locations1 site (Austin, Texas)
StatusRecruiting
StartedAugust 10, 2026
Main results expectedMarch 2028
Study endsAugust 2028
Registry record updatedAugust 17, 2026
Trial IDNCT07759115 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with multiple sclerosis (any major MS type) who report cognitive difficulties and have internet access.

Probably not a fit

Individuals without MS cognitive impairment or those unable to engage with an online program may see little or no benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This feasibility study tests a 12-week music-based eHealth intervention called Music-4-MS for adults with multiple sclerosis. The approach uses music training and listening to engage multiple senses with the goal of supporting cognitive and emotional well-being. Researchers will assess practicality, engagement, and preliminary effects on cognition and mood to inform future larger trials. Participants must have MS, self-reported cognitive issues, and internet access to participate. The study is led by the University of Texas at Austin with collaboration from the National Institute of Nursing Research.

Why it matters

Potential benefit: If successful, the program could offer a non-invasive and engaging option to help preserve or improve cognitive function and mood in MS patients.

How similar studies have gone: Prior cognitive rehabilitation research supports multisensory approaches, but feasibility of a music-based digital intervention in MS is still being explored.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosed with multiple sclerosis (relapsing remitting, secondary progressive, primary progressive)
* Diagnosed more than 6 months prior to starting study
* Self-reported cognitive impairment as assessed by having at leased 5 problems "sometimes" or more often on the Perceived Deficits Questionnaire
* Read, write, and understand English
* Access to internet

Exclusion Criteria:

* Diagnosed with another neurological condition that causes cognitive impairment
* MS exacerbation within the last 30 days
* Professional musician (primary source of income)

Where it's running

  • University of Texas at Austin
    Austin, Texas, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.