Identifying biomarkers in autoimmune and inflammatory diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify cytokine and lymphocyte biomarkers in patients with autoimmune diseases, systemic vasculitis, and autoinflammatory diseases. By collecting biological samples as part of routine patient care, the study seeks to develop prognostic biomarkers that can personalize treatment and follow-up for these patients. The research is conducted at a certified national reference center, focusing on understanding the immunological profiles that predict disease activity and treatment response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of 18 years of age or older
* Patients with autoimmune systemic disease, systemic vasculitis or autoinflammatory disease, defined by the international criteria in force for each pathology, among the following:

  * Connectivities: lupus, Sjögren syndrome, antiphospholipid syndrome, mixed connectivity and Sharp syndrome, scleroderma, myositis
  * Vasculitis of large, small and medium vessels: giant cell arteritis, Takayasu arteritis, Behçet disease, ANCA vasculitis, cryoglobulinemic vasculitis, IgA vasculitis (rheumatoid purpura)
  * Buerger's disease (obliterating thromboangitis)
  * Granulomatosis and sarcoidosis
  * Uveitis
  * Monogenic and polygenic autoinflammatory diseases: family Mediterranean fever, TRAPS, CAPS, chronic atrophic polychondritis, pericarditis
  * Recurrent fevers and unexplained inflammatory syndromes
  * Inflammatory amyloidosis
* Patients affiliated to French social security

Exclusion Criteria:

* Vulnerable populations:

  * Persons deprived of liberty by judicial or administrative decision;
  * Persons receiving psychiatric care without their consent;
  * Adult subject to a legal protection measure (guardianship, curatorship);
  * Persons unable to give their consent.

Where it's running

• Département de Médecine Interne et Immunologie Clinique (DMIIC), Hôpital Pitié-Salpêtrière
  Paris, France, France Recruiting

Study contacts

• Principal investigator: David Saadoun, Professor — Assistance Publique - Hôpitaux de Paris
• Study coordinator: David Saadoun, Professor
• Email: david.saadoun@aphp.fr
• Phone: +33142161051

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.