Understanding how GABA affects immune responses in autoimmune diseases
Decipher and target GABA metabolism and GABA receptor-mediated signaling in autoimmune diseases
['FUNDING_R01'] · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · NIH-11012895
This study is looking at how a substance called GABA affects inflammation caused by immune cells, with the hope of finding new treatments for autoimmune diseases that could help patients feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RESEARCH INST NATIONWIDE CHILDREN'S HOSP (nih funded) |
| Locations | 1 site (COLUMBUS, UNITED STATES) |
| Trial ID | NIH-11012895 on ClinicalTrials.gov |
What this research studies
This research investigates the role of γ-aminobutyric acid (GABA) in regulating inflammation caused by T cells, which are crucial for immune responses. By analyzing how GABA metabolism and receptor signaling influence T cell behavior, the study aims to identify potential therapeutic strategies for autoimmune diseases. The approach includes using animal models to explore the effects of manipulating GABA levels and its receptors on T cell activity and inflammation. Patients may benefit from insights that could lead to new treatments targeting GABA pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals, particularly children under 11 years old, suffering from autoimmune diseases.
Not a fit: Patients with autoimmune diseases not involving T cell-mediated inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that better manage autoimmune diseases by targeting GABA metabolism.
How similar studies have performed: While the specific targeting of GABA in autoimmune diseases is a novel approach, related research has shown promising results in understanding metabolic influences on immune responses.
Where this research is happening
COLUMBUS, UNITED STATES
- RESEARCH INST NATIONWIDE CHILDREN'S HOSP — COLUMBUS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, RUONING — RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- Study coordinator: WANG, RUONING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease