Understanding B cell Behavior in SLE and Other Autoimmune Diseases
Official title: Regulation of B cell Responses in SLE and Other Autoimmune Diseases
Funded at Emory University · NIH-11332689 · Data updated 2026-11-12
Researchers are studying how B cells and their epigenetic marks behave in people with autoimmune diseases like SLE to find new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 1, 2014 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $234,750 |
| NIH project number | 5U19AI110483-13 |
| Project ID | NIH-11332689 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with autoimmune diseases such as SLE who have active or remitting disease and are undergoing immune profiling.
✕Less likely to help
Some patients may not experience direct benefit if their disease biology differs from those studied or if findings do not translate into therapies.
What this research studies
This project focuses on how B cells change at the genetic and epigenetic level in autoimmune diseases. By analyzing different B cell subtypes in people with active disease and in remission, researchers aim to map signatures that may explain why some patients respond differently to treatments. The work uses patient samples to study DNA methylation, histone modifications, and gene expression, with the goal of identifying targets for more effective, personalized therapies. Findings could lead to new strategies to modulate B cell activity and improve disease control for patients.
Why it matters
Potential benefit: Potential to guide the development of more precise B cell–targeted therapies that improve disease control and reduce flares.
How similar studies have gone: Previous studies have identified B cell–related signatures in autoimmune diseases, supporting the potential for translating epigenetic findings into therapies.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Boss, Jeremy M. — Emory University
- Study coordinator: Boss, Jeremy M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.