Identifying biomarkers for autoimmune diseases triggered by immunotherapy
Official title: NOVEL HUMORAL AND CELLULAR BIOMARKERS OF AUTOIMMUNE DISEASES CAUSED BY IMMUNOTHERAPY
Funded at Baylor College of Medicine · NIH-10917057 · Data updated 2026-11-12
This study is looking at how certain cancer treatments called immunotherapy might cause autoimmune diseases in patients, and it aims to find markers that can help predict who might be at risk, so that those receiving these treatments can have safer options.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $200,107 |
| NIH project number | 5R21AI159379-02 |
| Project ID | NIH-10917057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing immunotherapy who may be at risk for developing autoimmune diseases.
✕Less likely to help
Patients who are not receiving immunotherapy or those without a history of autoimmune diseases may not benefit from this research.
What this research studies
This research investigates how immunotherapy, particularly immune checkpoint inhibitors, can lead to autoimmune diseases in patients. It aims to identify specific biomarkers that can predict the risk of these immune-related adverse events, such as autoimmune diabetes and adrenal insufficiency. By analyzing immune responses at a cellular level, the study seeks to uncover molecular pathways that could help prevent these serious side effects. Patients who are candidates for immunotherapy may benefit from this research as it could lead to safer treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved safety and management of immunotherapy for patients at risk of autoimmune diseases.
How similar studies have gone: Previous research has shown promising results in identifying biomarkers for autoimmune responses in patients receiving immunotherapy, indicating that this approach has potential for success.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Lee, Hyun-Sung — Baylor College of Medicine
- Study coordinator: Lee, Hyun-Sung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.