Understanding how genetic variants affect gene expression in autoimmune diseases
Official title: Statistical integration of single-cell eQTL studies and GWAS with application to autoimmune diseases
Funded at University of Washington · NIH-11032617 · Data updated 2026-11-12
This study is looking at how certain genes in immune cells might affect autoimmune diseases like ankylosing spondylitis, with the goal of finding better treatments for patients by understanding which genes are involved.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 13, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $189,824 |
| NIH project number | 1K01HG013983-01 |
| Project ID | NIH-11032617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autoimmune diseases, particularly those with ankylosing spondylitis or axial spondyloarthritis.
✕Less likely to help
Patients with non-autoimmune conditions or those not diagnosed with specific autoimmune diseases may not benefit from this research.
What this research studies
This research investigates the relationship between genetic variants and gene expression specifically in immune cells related to autoimmune diseases. By developing new statistical methods, the project aims to integrate data from single-cell expression studies and genome-wide association studies (GWAS) to better understand how these genetic factors contribute to disease. Patients may benefit from insights gained about which genes and cell states are involved in their conditions, potentially leading to more targeted treatments. The research will analyze data from immune cells, particularly focusing on conditions like ankylosing spondylitis and axial spondyloarthritis.
Why it matters
Potential benefit: If successful, this research could lead to more precise treatments for autoimmune diseases by identifying key genetic factors involved in these conditions.
How similar studies have gone: Previous research has shown promise in using similar integrative approaches to understand genetic influences on diseases, indicating potential for success in this novel application.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Qi, Guanghao — University of Washington
- Study coordinator: Qi, Guanghao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.