Understanding genetic factors in autoimmune diseases in Peru
Deciphering the Genetic Architecture of Autoimmune Diseases
This study is looking to see how genetic differences affect autoimmune diseases in people from Peru to better understand their health needs.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 115 Years |
| Sex | All |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 2 sites (Bethesda, Maryland and 1 other locations) |
| Trial ID | NCT06948110 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the genetic factors contributing to autoimmune diseases, particularly focusing on individuals native to Peru. Researchers will analyze how genetic variations influence the risk and manifestation of conditions like systemic lupus erythematosus among this population. Participants will undergo two clinic visits spaced two weeks apart, where their genetic information and health data will be collected. The study seeks to address health disparities and improve understanding of autoimmune diseases in non-European populations.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 18 and older diagnosed with autoimmune diseases such as systemic lupus erythematosus, Sjogren's disease, and rheumatoid arthritis.
Not a fit: Patients with chronic viral diseases like HIV or hepatitis C will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better diagnosis and treatment strategies for autoimmune diseases in diverse populations.
How similar studies have performed: While there is limited research specifically targeting the genetic architecture of autoimmune diseases in indigenous populations, studies in other regions have shown the importance of genetic diversity in understanding these conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: Any person who meets the criteria for inclusion in the study will be considered and must have the patient's signed informed consent for participation. Autoimmune Disease Diagnosis: Cases: * Patients diagnosed with SLE, Sjogren's disease, scleroderma, rheumatoid arthritis, seronegative spondyloarthropathies, and systemic vasculitis, as defined by the American College of Rheumatology classification criteria. * Over 18 years old Controls: * Family members of identified cases, and unrelated individuals. The controls would be from the same community as the patients and families studied, and of the same age and gender. Screening for autoimmune diseases and allergic diseases will be performed. * Over 18 years old EXCLUSION CRITERIA: -People diagnosed with a chronic viral disease: HIV, hepatitis C or HTLV-1.
Where this trial is running
Bethesda, Maryland and 1 other locations
- National Human Genome Research Institute (NHGRI) — Bethesda, Maryland, United States (Completed)
- Amazon Rainforest — Lima, Peru (Recruiting)
Study contacts
- Principal investigator: Cristina M Lanata, M.D. — National Human Genome Research Institute (NHGRI)
- Study coordinator: Cristina M Lanata, M.D.
- Email: cristina.lanata@nih.gov
- Phone: (301) 451-2302
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.