Investigating how unique antibody sequences may contribute to autoimmune diseases.
Official title: Divergence of V-region sequences from the human proteome as a factor in autoimmune diseases and the immunogenicity of therapeutic antibodies.
Funded at University of Alabama at Birmingham · NIH-10991364 · Data updated 2026-11-12
This study is looking at special types of antibodies in people with autoimmune diseases and healthy individuals to see how they might affect the immune system, helping us learn more about these conditions and how to better understand them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $216,068 |
| NIH project number | 5R21AI175868-02 |
| Project ID | NIH-10991364 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autoimmune diseases who may have unique antibody profiles.
✕Less likely to help
Patients without autoimmune conditions or those who do not produce antibodies may not benefit from this research.
What this research studies
This research explores the role of rare antibody sequences in autoimmune diseases by analyzing millions of antibody sequences from both healthy individuals and those with immune-mediated disorders. Using advanced data from curated databases, the study aims to identify specific sequences that may trigger immune responses in patients. By examining these unique sequences, researchers hope to better understand their potential immunogenicity and how they relate to autoimmune conditions. This large-scale analysis leverages decades of research to uncover new insights into the immune system's behavior.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for autoimmune diseases.
How similar studies have gone: Previous research has shown promise in understanding antibody sequences and their roles in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Schroeder, Harry William — University of Alabama at Birmingham
- Study coordinator: Schroeder, Harry William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.