Sponsor or institution
Clinical trials and research at Massachusetts General Hospital
As of November 12, 2026, Find a Trial lists 355 clinical trials run by Massachusetts General Hospital that are recruiting, at sites in 14 countries (most in United States (347), South Africa (5), Italy (3)). 1 was first registered in the last 30 days. By phase: Phase 2 (54), Phase 4 (22), Phase 1 (19), Early Phase 1 (12). There are also 2,224 NIH-funded research projects at this institution, with $1.5 billion in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 355Clinical trials
- 2224NIH research projects
- 1New in 30 days
- 14Countries
Newest trials
All recruiting trials (newest 150 of 355)
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Metabolomic biomarkers for myotonic dystrophy
This study tests whether urine and blood tests, along with muscle function tests, can detect and measure myotonic dystrophy activity and severity without relying on muscle biopsies.
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Two group-based, telehealth caregiver programs to reduce stress in dementia caregivers
This trial tests whether Caring Together or Savvy Caregiver, delivered by telehealth, best reduces caregiver stress for people caring for someone with memory loss.
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Heart Rate Variability Biofeedback for Anxiety in Autistic Youth
This study tests a wearable heart rate variability biofeedback tool to see if it helps reduce anxiety in autistic teens.
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Brillouin hydration mapping to study cornea health
Researchers test a Brillouin microscope to see if it can measure corneal water content in healthy people and those with eye conditions.
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Identifying Signatures of Gut Interoception in Functional Dyspepsia and Anorexia Nervosa
This study tests how the gut-brain connection works in people with functional dyspepsia or anorexia nervosa using brain imaging.
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Oral Extubation Right After Cardiac Surgery
This trial tests whether waking patients and removing the breathing tube in the operating room after elective cardiac surgery helps recovery more quickly without added risk.
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TMS plus Emotion Regulation Skills Training for Borderline Personality Disorder
This study tests whether adding transcranial magnetic stimulation to emotion regulation skills training helps people with borderline personality disorder improve their ability to manage emotions.
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Glofit-GemOx Bridging to Liso-cel for Relapsed/Refractory Large B-Cell Lymphoma
This trial tests whether a bridging therapy with Glofit-GemOx followed by lisocabtagene maraleucel helps people with relapsed or refractory large B-cell lymphoma.
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Open Broström repair with BioBrace augmentation for chronic ankle instability
This study tests whether adding the BioBrace implant to a standard Broström repair improves outcomes for adults with chronic lateral ankle instability.
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BRIDGE NET: virtual collaborative care for patients with serious mental illness and new cancer
A virtual, team-based care program tests whether BRIDGE NET can improve care for adults with serious mental illness who are newly diagnosed with cancer.
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Lumateperone for Bipolar Depression with Obesity: Effects on Mood and Brain Aging
This trial tests whether lumateperone helps mood symptoms in adults with bipolar depression and obesity, and whether it affects inflammation and brain aging markers over about 6 weeks.
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Infliximab plus prednisone vs prednisone alone for ICI-associated AKI
This study tests whether adding infliximab to prednisone helps adults with kidney injury caused by cancer immunotherapy recover kidney function faster than standard prednisone alone.
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Addressing Cancer Care Equity With Social Needs Screening for Leukemia
This study tests whether screening for health-related social needs and early social work support can help adults with leukemia feel more supported and improve care-related outcomes.
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Behavioral program to help depressed nursing home residents see if it helps
This study tests the InSTILL program to see if it is feasible, satisfactory, and helpful for residents of skilled nursing facilities who have depressive symptoms.
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Nicotinamide Riboside and Brain Energy in Healthy Adults
This study tests whether taking nicotinamide riboside by mouth for 2 weeks can change brain energy metabolism in healthy adults aged 18–65.
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CBT-AR vs Nutrition Counseling for ARFID in children and teens
This trial tests whether cognitive-behavioral therapy for ARFID (CBT-AR) or nutrition counseling helps 10- to 18-year-olds with ARFID.
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Nitric Oxide Use to Predict Vasospasm in Aneurysmal Subarachnoid Hemorrhage
This study tests whether nitric oxide consumption in CSF can predict cerebral vasospasm in patients with aneurysmal SAH.
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Personalized blood-thinner plan for leg artery disease after repair
A personalized plan using a blood test to tailor antiplatelet therapy is being tested against standard treatment in adults with PAD after a procedure to restore blood flow.
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Stress management and meditative movements for depression with physical symptoms in Asian Americans
This study tests whether combining the SMART program with meditative movements like Qigong/Tai Chi can help Asian American adults with major depression who also have physical symptoms.
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Lung cancer risk from CT scans in people with a family history
Researchers test a deep learning model called Sybil to see if chest CT images can predict future lung cancer risk in people who have relatives with the disease.
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Two online pain-management programs for adults with chronic non-arthritic hip pain
This study tests whether two video-delivered programs for hip pain are feasible for adults with chronic, non-arthritic hip pain.
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Advanced imaging to see how immunosuppression affects lung fibrosis activity
This trial will test whether immunosuppression changes PET and MRI measurements of active collagen deposition and tissue injury in people with non‑IPF interstitial lung disease who are starting treatment.
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Checking oxytocin levels in children with pituitary disease
This pilot will test whether a single oral dose of combined estrogen/progestin boosts oxytocin release in young people with pituitary-related hormone deficiencies and matched controls.
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Psychedelic coaching added to ketamine treatment for treatment-resistant depression
This trial will test whether adding psychedelic integration coaching to ongoing ketamine or esketamine maintenance helps people with treatment-resistant depression.
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Phone app for remote symptom monitoring and management during cancer treatment
This trial will test whether the ASSIST smartphone app can be used and is liked by people with breast cancer, colorectal cancer, or lymphoma who are starting systemic treatment.
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Non-contrast CT V: See If CT has a Role in Finding Pulmonary Embolism
This study tests whether additional low-dose, non-contrast CT scans can help detect pulmonary embolism in patients who are already being evaluated for suspected PE.
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Nurse-led coping and support for TNBC patients
This test will see if a nurse-led coping and supportive care program can help people with triple-negative breast cancer feel better during the transition from active treatment to surveillance.
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Increasing Cardiac Rehabilitation Attendance After a Secondary MI
This trial tests whether a clinician message + a patient phone call can help adults with a secondary/type 2 MI attend more cardiac rehabilitation sessions.
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Buspirone for Anxiety in Autistic Youth
This study tests whether buspirone helps reduce anxiety in kids and teens with autism compared to a placebo.
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Biomarkers for Response to ECP in Lung Transplant Patients with CLAD
This study tests early biomarkers from blood and MRI to see if extracorporeal photopheresis helps lung transplant patients with chronic lung allograft dysfunction.
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Improving recovery and quality of life after ostomy surgery for older adults
This pilot tests a web-based geriatric assessment program to help adults age 65+ recover and maintain quality of life after ileostomy or colostomy surgery.
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Tracking changes in Angelman syndrome over 12 months
This study will see how developmental skills, behavior, sleep, and brain activity change over one year in children and adults with a genetically confirmed diagnosis of Angelman syndrome.
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Savvy medication-support program for people after stroke
This project will test whether Savvy — short phone-based psychological exercises, a weekly pill organizer, and text reminders — helps stroke survivors take their blood-pressure medicines and improve blood pressure compared with usual care.
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Ivonescimab alone or with carboplatin/pemetrexed for advanced NSCLC with actionable alterations
This trial tests if ivonescimab, alone or with chemotherapy, can shrink tumors in advanced NSCLC patients who have actionable genomic alterations after prior targeted therapies.
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Resistance exercise and nutrition support for transgender women and gender-diverse adults starting estrogen therapy
This will test whether a resistance exercise program plus nutrition counseling helps preserve or improve muscle mass and strength in transgender women and gender-diverse adults who are starting estrogen-based hormone therapy.
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Resilient Families for NICU Parents
This study tests a dyadic resiliency program called Resilient Families (R-FAM) to see if it can reduce distress and improve relationships for NICU parents, compared with a single-session educational control.
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Immune response after delivering melphalan directly to the liver for uveal (eye) melanoma that has spread to the liver.
This test will see how the liver's immune system responds when people with uveal melanoma that has spread to the liver receive melphalan delivered directly to the liver through percutaneous hepatic perfusion.
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Changing Lives and Changing Outcomes-9 group program at Worcester Recovery Center and Hospital
This program will try a nine-session cognitive-behavioral group to help adults with serious mental illness who have current or past legal involvement increase mental health awareness and lower chances of future legal problems.
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Venetoclax added to reduced-intensity conditioning for combined stem cell and kidney transplant
This trial tests whether adding venetoclax to a reduced-intensity conditioning regimen is safe for adults with blood cancers who are receiving a combined stem cell and kidney transplant from a matched or partially matched donor.
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Ziftomenib and Mezigdomide in adolescents and adults with relapsed or refractory AML with KMT2A rearrangement or NPM1 mutation
This study tests a combination of ziftomenib and mezigdomide to see if it is safe and tolerable in teens and adults whose AML has KMT2A rearrangements or NPM1 mutations and has come back or not responded to treatment.
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Purified Cortrophin® Gel for treating acute gout flares at two dose levels
This study will try two single injections (40 U and 80 U) of Purified Cortrophin® Gel to see which dose better and more quickly reduces pain in adults having an acute gout flare.
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Same-day Lenacapavir PrEP with follow-up choice to see if people stay on PrEP longer
This trial tests whether letting people choose where they get follow-up care after starting lenacapavir PrEP helps them stay on PrEP longer.
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MB-Spirit program to improve psychological and spiritual well-being in stressed adults.
This program will test whether an 8-week online MB-Spirit course helps adults with high stress improve spiritual well-being and psychological health and whether their brain scans change after the course.
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Cardiac and fetal health in pregnancy at high altitude
This observational study tests how living at high altitude affects heart function and fetal growth in pregnant women, compared with similar pregnancies at sea level.
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Focused ultrasound to promote recovery after severe brain injury.
This test uses low-intensity focused ultrasound on adults with disorders of consciousness after severe brain injury to see if it improves responsiveness and brain activity.
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Opioid-free versus usual discharge pain plans after major orthopedic surgery.
This pilot trial will test whether sending adults home after major orthopedic surgery with an opioid-free pain prescription provides pain control similar to the usual opioid-containing prescription.
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Exercise to lower heart and artery risk in people with PTSD
This project will test whether a supervised exercise program can change brain activity and reduce artery inflammation in adults with PTSD who have or are at risk for atherosclerotic cardiovascular disease.
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Eplerenone versus chlorthalidone to improve heart blood vessel function after preeclampsia
This study will test whether eplerenone works better than chlorthalidone to improve coronary microvascular function in women who had preeclampsia and now have chronic high blood pressure and concentric left ventricular remodeling.
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NPC-1 (parthenolide and ipriflavone) for Alzheimer's blood biomarkers
This trial will test whether taking NPC-1 (a combination of parthenolide and ipriflavone) is safe, well tolerated, and changes blood tests linked to Alzheimer's in adults 55+ with subjective cognitive decline, mild cognitive impairment, or mild Alzheimer's who have biomarker evidence of disease.
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Online program providing personalized NF1 care letters plus videos or peer navigator support for adults with low health literacy
This study will test whether giving adults with NF1 and low health literacy personalized care letters plus either short, plain-language videos or a call with a trained peer navigator helps them better understand NF1 symptoms and care before their primary care visit.
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PROMOTE mobile app to improve physical function and wellbeing in lung cancer survivors
This project tests whether the PROMOTE mobile app can help adults with stage I–III non-small cell lung cancer undergoing curative chemotherapy improve their physical function and overall wellbeing.
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Smartwatch-guided exercise to prevent muscle loss during GLP-1 treatment
See if a smartwatch that tracks activity and body composition and sends exercise reminders helps people starting GLP-1 medications keep muscle and strength.
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Kisspeptin to measure GnRH neuron function in people with and without post-COVID-19 syndrome
We will give one intravenous kisspeptin dose and take frequent blood samples to see if people with post-COVID-19 syndrome have different GnRH/LH hormone responses than people who had COVID but did not develop long COVID.
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Pulsatile subcutaneous kisspeptin to trigger ovulation in women with hypothalamic amenorrhea
This trial tests whether two weeks of pulsed subcutaneous kisspeptin can trigger reproductive hormone release and stimulate ovarian follicle growth and egg release in women with hypothalamic amenorrhea.
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Behavioral health program for short-stay nursing facility residents and their care partners
This program will test whether the InSTILL behavioral health intervention helps short-stay skilled nursing facility residents with depressive symptoms and their primary support persons compared with minimally enhanced usual care.
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Lower GI imaging with a tethered camera capsule
This test tries a small camera capsule on a string that takes pictures of the lower gut without sedation for adults who are healthy or who have Lynch syndrome, Crohn's disease, or other inflammatory bowel diseases.
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Induction therapy with toripalimab plus cisplatin and docetaxel for head and neck squamous cell carcinoma
This study tests whether adding toripalimab to cisplatin and docetaxel induction therapy is safe and tolerable for adults with newly diagnosed locally advanced head and neck squamous cell carcinoma.
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Time Restricted Eating in Bipolar Disorder and Obesity
A randomized trial tests whether an 8-hour time-restricted eating plan helps adults with bipolar disorder who are overweight and mildly depressed compare to a wait-list control.
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Pectoral versus paravertebral nerve blocks for pain after immediate implant breast reconstruction
This will test whether paravertebral or pectoral nerve blocks better reduce pain and improve physical well-being for adults having immediate implant-based breast reconstruction.
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Activation-ligand trap therapy with exercise to help HFpEF patients
This trial tests whether adding activin-ligand trap therapy to an exercise program can improve peak oxygen use and thinking skills in people with HFpEF.
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Long-acting injectable cabotegravir for preventing HIV in people who inject drugs
This project tries long-acting injectable cabotegravir plus support services to prevent HIV in adults who inject non-prescription drugs and have sexual exposure risk.
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Imagined acupuncture for postoperative pain after spine surgery
A 30-minute video-guided imagined acupuncture session delivered daily for 7 days after spine surgery is being tested to see if it helps reduce pain and opioid use for adults.
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Partner HIV self-testing kits plus PrEP support for HIV-negative new mothers
This pilot will try giving partner HIV self-test kits plus counseling to help HIV-negative pregnant or postpartum women and their male partners in KwaZulu-Natal use HIV self-testing and start PrEP when needed.
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Symptom monitoring with feedback to help advanced CKD patients feel better
A small, 70-person trial will test whether regularly asking patients to report CKD symptoms and sharing those results with clinicians can improve quality of life and symptom burden.
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Video-guided imagined acupuncture for chemotherapy-related nerve pain
This program will try a video-guided imagined acupuncture (VGAIT) approach to help people with ongoing nerve pain after taxane chemotherapy for early-stage breast cancer.
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Combining diet and stress-management with advanced treatments for Crohn's and ulcerative colitis
This study will test whether adding diet guidance and stress-management support to advanced IBD medications helps people with active Crohn's disease or ulcerative colitis achieve and maintain remission.
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45th Multicenter Airway Collaboration on ED initiation of Airsupra
This trial tests whether giving Airsupra in the emergency department reduces asthma recurrence over three months for adults sent home on a short course of steroids.
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Annual Wellness Visits with or without GRACE support for older adults with complex needs
This project will see if adding the GRACE geriatric care approach to Medicare Annual Wellness Visits helps older adults with complex needs and their caregivers stay healthier and avoid hospital visits.
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Diet changes to see if bile acids and gut bugs shift in people with colorectal adenoma
A diet shift toward more plants and fewer animal products is being tested to see if it changes gut bile acids and microbiome in adults with a history of colorectal adenoma.
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Online parent education to help manage anxiety in 2–7-year-old children
This trial will test whether brief, self-guided online education for parents of children aged 2–7 helps them better manage their child's anxiety.
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Earplugs to reduce noise-related heart and metabolic risk
This study will test whether wearing noise-canceling earplugs reduces stress-related brain activity and other heart-risk markers in adults with atherosclerosis or common cardiovascular risk factors who are bothered by transportation noise.
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Varenicline plus enhanced TMS to help adults quit smoking and vaping
This study tests whether adding active enhanced accelerated transcranial magnetic stimulation (aTMS) to varenicline helps adults 18–65 quit nicotine use more effectively than varenicline with sham stimulation.
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Adapted resiliency program for parents of adolescents and young adults with cancer
This project will try a group-based resiliency program to reduce distress in parents who care for adolescents and young adults (ages 15–39) with cancer.
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Intravenous and topical tranexamic acid to reduce drain fluid after breast reduction
This trial will test whether giving tranexamic acid intravenously and placing it in one breast drain during bilateral breast reduction can reduce postoperative drain fluid in adults.
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Detecting brain injury from repeated blast exposure in Navy SEALs
This study will test whether blood tests and brain imaging can detect brain injury from repeated blast exposure in active-duty Navy SEALs.
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Botensilimab and balstilimab plus SBRT for liver‑metastatic colorectal cancer
This tests whether adding two immune drugs, botensilimab and balstilimab, to focused liver radiation (SBRT) can help people with chemorefractory, non‑MSI‑high colorectal cancer that has spread to the liver.
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Mindfulness-based Cognitive Therapy versus a Health Enhancement Program for chronic pain and depression in older Black adults
This pilot will see if Quiet Focus, a culturally adapted mindfulness-based cognitive therapy program, helps older Black adults with long-term pain and mild-to-moderate depression more than a general health program.
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Momelotinib given before and after allogeneic bone marrow transplant for myelofibrosis
This test will see if giving momelotinib around the time of allogeneic hematopoietic cell transplant is safe and tolerable for adults with intermediate- or high-risk myelofibrosis.
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ActiveGirls physical activity program for hormone health and diabetes-risk prevention in girls ages 8–12
This study will test whether a 6-month ActiveGirls program with coaching and messages helps girls ages 8–12 improve hormone health and lower markers of diabetes risk compared with a lower-intensity, delayed program.
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Preventing early-onset colorectal tumors with tirzepatide
This trial will test whether the diabetes/weight-loss drug tirzepatide changes tissue, blood, urine, stool, and microbiome markers linked to colorectal cancer risk in adults under 50 who recently had adenomas.
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Lowering blood pressure after stroke with home monitoring and virtual group visits
This will see if adding virtual group visits to home blood pressure checks helps lower blood pressure in people who had a recent mild-to-moderate stroke.
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Building Connections: improving cancer screening, weight management, and mental health for adults in vulnerable communities
This program will try to improve cancer screening, weight management, and mental health care for adults served by community clinics in Massachusetts.
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Giving adults their genetic risk score for coronary artery disease to see if it changes heart health.
This will see if telling adults aged 30–75 their genetic risk score for coronary artery disease changes LDL cholesterol and preventive care actions over one year.
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Heated yoga, sauna, or a mindfulness app for depression
This project will test whether heated yoga, sauna sessions, or a mindfulness app reduce symptoms in adults with at least moderate depression.
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IV allopregnanolone to improve extinction retention and block reconsolidation in PTSD.
This study will test whether a single IV dose of allopregnanolone helps adults with chronic PTSD better retain extinction learning or block reconsolidation of traumatic responses.
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Elinzanetant for menopausal hot flashes and heart health
This phase 2 study tests whether the drug elinzanetant can improve blood vessel health in peri- and post-menopausal women with moderate to severe hot flashes.
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Ivonescimab plus FOLFOX for advanced HER2-negative stomach and gastroesophageal junction adenocarcinoma
This study tests whether adding ivonescimab to standard FOLFOX chemotherapy helps people with advanced, HER2-negative stomach or gastroesophageal junction adenocarcinoma as first-line treatment.
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Mindfulness-based neurofeedback for teens with high repetitive negative thinking
This study will see if real-time fMRI mindfulness-based neurofeedback helps adolescents with high repetitive negative thinking reduce brain network activity linked to rumination compared with a sham procedure and healthy peers.
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Digital information and support app for people starting neoadjuvant therapy for pancreatic cancer
This pilot will test whether the PDAC-PATHWAYS app is feasible and acceptable for people starting neoadjuvant therapy for pancreatic ductal adenocarcinoma.
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Spironolactone to improve blood pressure after pregnancy-related hypertension
This trial will try taking spironolactone for three months after delivery to see if it lowers blood pressure and prevents heart changes in women who had preeclampsia or gestational hypertension and were overweight before pregnancy.
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Wireless thermal capsule to detect gastrointestinal temperature changes
This study tests a swallowable wireless thermal capsule to see if it can collect temperature data from the GI tract in healthy adults.
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Mezigdomide plus talquetamab for relapsed and refractory multiple myeloma
This phase 1 test tries combining mezigdomide with talquetamab and dexamethasone in adults with relapsed and refractory multiple myeloma who have had at least three prior therapies to find a safe dose and see if it helps.
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Million Anesthesia Cases: Preoperative fasting and perioperative outcomes
This project will see if longer pre-surgery fasting harms people having procedures with anesthesia by looking at symptoms like hunger and thirst, physiologic changes such as low blood pressure and blood sugar shifts, and risks like aspiration and nausea.
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Reducing emotional distress for people with young-onset dementia and their care partners
This project will test whether a brief, six-session virtual program delivered to people with young-onset dementia and their care partners can prevent long-term emotional distress.
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Increase resilience for lymphoma survivors after treatment
A mind-body group program is tested to see if it helps early post-treatment lymphoma survivors cope better than usual care.
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A resilience-based approach to improve long-term quality of life for lymphoma survivors
This trial tests whether a resilience-focused program helps lymphoma survivors feel a better quality of life compared with a health-education program.
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Rituximab vs multiple approved NMOSD therapies to prevent relapses
This study tests whether rituximab or one of four other approved medicines is better at preventing NMOSD relapses in adults who have AQP4-IgG.
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Brain pathways that support arm recovery after stroke
This trial will try 30 hours (over 6 weeks) of targeted Arm Basis Training versus usual care to see if it improves proximal arm motor control in people 3–6 months after a first ischemic or hemorrhagic stroke with moderate to severe arm impairment.
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Noninvasive blood pressure monitoring in newborns using a new device
This study is testing a new device that uses light to measure blood pressure in newborns to see if it works better than traditional methods.
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Web-based mind-body program to build resilience for adults with non‑traumatic upper‑extremity pain and risky substance use
This trial will try an online mind‑body program to help adults with non‑traumatic upper‑extremity pain who also engage in risky substance use build resilience and better cope with pain and substance urges.
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Imaging study to understand brain function in epilepsy
This study looks at how epilepsy changes brain function by using brain scans to see if they can spot areas that aren't working right compared to healthy people.
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Smartphone-delivered Therapeutic Evaluative Conditioning for suicidal thoughts and behavior
This study will test whether a smartphone program called Therapeutic Evaluative Conditioning (TEC-S) can reduce suicidal thoughts and behaviors in adults who have had frequent recent suicide ideation.
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Peer recovery coaching to help people with opioid use disorder quit smoking
This test pairs people on medication-assisted treatment for opioid use disorder with peer coaches to help them quit or reduce smoking.
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CytoGam immunoglobulin to prevent late CMV disease after liver or kidney transplant
This trial will try giving monthly CytoGam infusions after standard antiviral pills end to see if it lowers the chance of late CMV disease in high-risk liver, kidney, or combined liver-kidney transplant patients (donor positive, recipient negative).
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Using brain stimulation to improve memory and motivation in older adults
This study is testing if a type of brain stimulation can help improve memory and motivation in older adults, including those showing early signs of Alzheimer's disease.
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High-dose inhaled nitric oxide for adults with severe pneumonia on ventilators
This study will test whether short courses of high-dose inhaled nitric oxide help adults on ventilators with severe pneumonia recover and how the treatment affects methemoglobin levels.
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Omalizumab given by weight for food allergy
This study will test whether higher, weight-based doses of omalizumab are safe and help people with food allergies, including those with very high allergic antibody (IgE) levels, tolerate their allergens better.
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Prednisone in adults with an immune-related subtype of autism
This study tests whether prednisone, an anti-inflammatory drug, can help adults with a specific immune-related form of autism compared to a placebo.
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Preventive behavioral intervention for young adults with psychotic experiences
This study is testing if a new Resilience Training program can help college freshmen and sophomores who are at risk for serious mental illnesses feel better and prevent issues like psychosis, mood swings, and anxiety.
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Tulavi Allay nerve cap to prevent neuroma pain after finger or toe amputation
Tests whether placing a Tulavi Allay nerve cap on a cut digital nerve at the time of traumatic amputation reduces neuroma-related pain in adults.
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Group telehealth program to help adults with chronic graft-versus-host disease
This program tests whether the HORIZONS group telehealth sessions help adults with moderate to severe chronic graft-versus-host disease manage symptoms and improve quality of life compared with usual care.
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AI analysis of chest X-rays to identify people at high lung cancer risk for CT screening
This project tests whether an AI that flags people at high 6-year lung cancer risk from chest X-rays can increase CT screening in adults 50–77 who currently or formerly smoked.
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Mobile app to deliver CBT-AR for ARFID
A mobile app is being tested to see if it can deliver cognitive-behavioral therapy for ARFID to adults who have not yet received face-to-face CBT-AR.
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Digital program to reduce depression and cannabis use
This trial will test a digital program called AMP-C to see if it reduces depressive symptoms and cannabis use in adults with both major depression and problematic cannabis use.
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Personalized risk-based follow-up for cervical cancer screening in practice
This trial tests a personalized cervical cancer screening approach in primary care patients to see if reminders and outreach can improve how people are followed after a Pap/HPV test.
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Estrogen therapy and heart health in women with POI
This study tests whether starting estrogen replacement helps heart-health markers in women newly diagnosed with POI compared with healthy peers.
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WISH 2.0: Strengths and Happiness program for people with IBS
This trial will test a positive psychology program to see if it improves well-being and gut symptoms in adults with IBS compared with an educational program.
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Flotufolastat F 18 PET scanning for men with very low PSA after prostatectomy
This study will test whether a single flotufolastat F 18 PET scan can find sites of recurrent prostate cancer in men with very low PSA levels after radical prostatectomy.
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Adderall XR for attention problems in children and teens with autism
This 10-week study will test whether Adderall XR (mixed amphetamine salts) helps reduce ADHD symptoms and changes brain activity in children and adolescents (ages 8–18) who have autism.
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Zanubrutinib, obinutuzumab, and sonrotoclax for newly diagnosed CLL or SLL
This trial tests whether the three‑drug combination of zanubrutinib, obinutuzumab, and sonrotoclax can produce undetectable measurable residual disease (uMRD) in people with previously untreated CLL or SLL.
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Improving coronary blood flow in women with HIV and diabetes or chronic kidney disease
This study will test whether referring women with HIV and diabetes or chronic kidney disease to a specialist so they can be considered for SGLT2 inhibitor medicine, compared with health education alone, improves blood flow in their hearts.
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Virtual cognitive rehabilitation program for refugees with traumatic brain injury
This trial will test whether a trauma-informed, paraprofessional-led virtual program can help English- and Spanish-speaking refugees and asylum seekers (ages 18–65) who have had mild-to-moderate TBI and are experiencing memory or thinking problems.
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Elranatamab plus under-the-skin isatuximab for relapsed/refractory multiple myeloma
This trial will test whether combining elranatamab with subcutaneous isatuximab helps people with relapsed or refractory multiple myeloma who have had at least two prior therapies.
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Evaluating cognitive dysfunction in patients with immune thrombocytopenia
This study is trying to see how common and serious thinking problems are in adults with immune thrombocytopenia and if these issues are linked to factors like fatigue and depression.
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Outpatient epcoritamab for second-line, non-transplant-eligible relapsed/refractory diffuse large B‑cell lymphoma
This tests whether outpatient epcoritamab can help adults with relapsed or refractory large B‑cell lymphoma who are not eligible for transplant after one prior therapy.
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Virtual Cognitive Behavioral Therapy for Insomnia in Cancer Survivors
This study is testing a virtual therapy program for insomnia to see if it helps cancer survivors sleep better compared to regular care.
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Targeted palliative care program for people with metastatic breast cancer
This trial will test a five-session TARGET-PC palliative care program to see if it helps people with metastatic breast cancer and their caregivers communicate better with clinicians and manage symptoms.
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A brief nurse-delivered program plus a digital app to help with breathlessness in advanced lung cancer
This trial tests whether a short, nurse-led program plus a digital app can help reduce breathlessness in adults with advanced lung cancer.
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Video-based discussion tool to help families of kids with cancer talk about goals of care
A video-based intervention (VIDEO-PEDS) is tested to see if it helps clinicians and parents of children with cancer better document and decide on goals of care and end-of-life plans.
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QuitVaping behavioral program with texting support to help teens stop vaping
This trial will try QuitVaping plus extra texting to see if it helps teens aged 14–18 who vape nicotine quit more than standard education and referral alone.
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Closing the gap between a positive FIT test and diagnostic colonoscopy
This project will test patient- and system-level strategies to increase follow-up colonoscopy after a positive FIT for patients aged 45–75 at a Boston community health center.
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Colorectal cancer screening for unscreened people aged 45–54
This project will try to find what helps or gets in the way of colorectal cancer screening for patients aged 45–54 at community health centers by talking with patients and staff and linking staff survey results to clinic records.
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Improving care transitions after colorectal surgery for older adults
This study will test whether a coordinated care transition program helps people 65 and older recover better and avoid being readmitted after elective colorectal surgery.
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Extended-release tacrolimus to improve thinking and memory in older kidney transplant recipients
This will try switching older kidney transplant recipients from immediate-release tacrolimus to an extended-release formulation to see if it improves thinking, memory, or other cognitive symptoms.
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Fasting versus continuing tube feeding before procedures for critically ill patients
This trial will test whether stopping tube feeding before a procedure or continuing it affects recovery for adults in the ICU on mechanical ventilation.
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Evaluating the healing outcomes of Mg OSTEOCRETE for bone defects
This study is testing a new synthetic bone material called Mg OSTEOCRETE to see if it helps people heal better after surgery for bone defects caused by tumors, injuries, or loose implants.
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Exercise program for patients with myotonic dystrophy type 2
This study tests a new exercise program for people with myotonic dystrophy type 2 to see if it can help improve their strength and muscle health over six months.
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Ivosidenib maintenance after allogeneic stem cell transplant for IDH1-mutant AML
This trial tests whether taking ivosidenib versus a placebo after allogeneic stem cell transplant can prevent relapse in adults with IDH1-mutant AML.
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Evaluating RELiZORB for managing pancreatic enzyme insufficiency in tube-fed patients
This study is testing if RELiZORB can help tube-fed patients with pancreatic enzyme insufficiency digest food better while they are in the hospital.
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Blocking IL-1β to reduce artery inflammation in people with coronary artery disease, including those with TET2 clonal hematopoiesis
This trial will see if canakinumab, a drug that blocks IL‑1β, reduces artery inflammation in adults with prior heart attack or coronary stents, some of whom have TET2 clonal hematopoiesis.
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Transplanting patients' own stem cells to treat Parkinson's disease
This study is testing if transplanting patients' own stem cells from their skin into their brains can safely help treat Parkinson's disease.
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Testing a smartphone app to help nondaily smokers quit smoking
This study tests a new smartphone app designed to help people who smoke occasionally quit smoking and see if it works better than an existing app.
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Primary palliative care for people undergoing stem cell transplant
We will try training transplant clinicians to provide basic palliative care during hospital stays to see if it works and is acceptable for adults having stem cell transplants.
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SGLT2 Inhibitor as Novel Gout Care in Gout with Hyperuricemia
A 12-week study tests whether empagliflozin 10 mg daily can lower serum urate in adults with gout and high uric acid.
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THRIVE-CAR-T mobile app to support people receiving CAR T therapy
The trial will test whether the THRIVE-CAR-T mobile app helps adults receiving CAR T-cell therapy manage symptoms, improve quality of life, and feel more confident in their care.
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Tracking family members at risk for inflammatory bowel disease
This study is trying to see if tracking family members of people with inflammatory bowel disease can help find out who is at risk of developing it and how to prevent it.
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Adapting a Skills-Based Smoking Cessation Program for Gender-Diverse Adults Under Stress
A skills-based smoking cessation program is being adapted and tested to see if it helps gender-diverse adults who smoke, especially when stressed by gender-related factors and mood problems.
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G-CSF after chemo-radiation for MGMT-methylated glioblastoma
This test checks whether giving G-CSF after standard chemo-radiation helps protect brain structure and thinking in adults with newly diagnosed MGMT-methylated glioblastoma.
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Genetic program for Progressive Supranuclear Palsy and related conditions
This study is collecting DNA from adults with Progressive Supranuclear Palsy and similar conditions to see how genetics might help improve diagnosis and care for patients.
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Ketamine-assisted group therapy for Spanish-speaking adults with depression
This pilot will try ketamine-assisted group therapy to see if it helps Spanish-speaking adults with depression feel better.
Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.
NIH-funded research (newest 40 of 2224)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Global TravEpiNet: Pregnant Travelers Health and Disease Prevention Network
This grant supports a national network to improve health and prevent infections among international travelers, with a special focus on pregnant travelers.
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Soluble ST2 and the course of lung injury in ARDS
A doctor-scientist at a top hospital is studying how a molecule called soluble ST2 may influence how lung injury starts and heals in patients with ARDS and related conditions.
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Role of airway macrophages in lung health and allergic disease
A doctor-scientist at a major hospital wants to study how immune cells in the airways develop and influence asthma and other airway diseases.
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Global TravEpiNet: Understanding and Protecting US Travelers, including Pregnant Travelers
A large U.S. network studies international travelers, including pregnant travelers, to understand illness risks and reduce the spread of infections.
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Gait speed from wearable sensors to guide ALS trials
A patient-friendly look at using wearable sensors to measure how fast people with ALS walk, to help run better ALS trials.
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Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
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Access for All in ALS: Coordinating Center powering a national ALS research network
A national ALS research program will coordinate clinical data and a long-term study of ALS patients and at-risk gene carriers to improve understanding and future treatments.
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Choline for fetal brain protection in pregnant women who drink heavily
Giving choline to pregnant women who drink heavily may help protect the baby’s brain and improve early development.
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Exploring low-level HIV viremia in people on standard HIV treatment in sub-Saharan Africa
This study follows adults with HIV in sub-Saharan Africa who are on the common TLD treatment to understand why small amounts of the virus stay in the blood and what that might mean for their health.
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Center for Innovative NeuroTech Advancement – Administrative Core
A funding opportunity from NIH to strengthen leadership and coordination for advancing neurotechnology with patient input and clinical impact.
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CINTA Transition Funding to Finish NeuroTech Projects
A funding opportunity helps finish and hand off innovative neurotechnology projects to ensure they’re ready for the next stage or end with clear documentation.
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Center for Innovative NeuroTech Advancement – Administrative Core
A patient-focused hub at a major hospital coordinates leadership and policy to speed brain-technology research into real healthcare use.
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Center for Innovative NeuroTech Advancement: Administrative Core
A national hub led by Massachusetts General Hospital to streamline leadership, policy, and coordination across neurotechnology initiatives to help patients faster access better brain-technology tools.
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Circadian Health and Dementia in AD and FTLD patients
A study at a major hospital will look at how daily sleep-wake rhythms relate to dementia in people with Alzheimer’s disease or frontotemporal degeneration.
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Circadian rhythm problems and dementia in adults and older adults
A study using data from people with Alzheimer's and related conditions to understand how sleep-wake patterns and daily rhythms relate to dementia.
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Circadian Health and Brain Health in Alzheimer’s and FTLD
Aiming to understand how daily sleep-wake rhythms relate to dementia by studying people with Alzheimer’s, FTLD, and healthy controls.
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Air Pollution and Well-Being in Uganda: Understanding Risks and How to Protect Children and Adults
A short study will explore how biomass smoke affects health and daily life in Uganda and test practical tips to reduce exposure.
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Air Pollution and Well-Being in Uganda: Reducing Biomass Smoke Risks and Improving Education
A short project in Uganda will look at how biomass smoke affects health and whether simple education can help families reduce exposure and protect children and adults.
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How network patterns in hospitals affect care quality for kids in emergency rooms
This grant looks at how hospital networks and centralization of care influence the quality of emergency care for children and aims to use better information sharing and telemedicine to improve outcomes.
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Genetic roots of stillbirth and developmental disorders
A genetic study from Massachusetts General Hospital will look for inherited and new DNA changes that contribute to stillbirth and related developmental disorders in families.
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Targeting RNA Splicing Abnormalities in ALS/FTD
A research team aims to understand and correct abnormal RNA splicing in ALS and related brain diseases to help patients in the future.
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Novel ways to teach the body’s immune system to accept a lung transplant without heavy drugs
A new approach in nonhuman primates aims to make lung transplants last a lifetime with less need for ongoing medicines.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
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B cells at the brain's borders: how they form and act in autoimmune brain diseases
Researchers are studying how immune B cells behave at the brain's outer layers in aging and autoimmune brain diseases to understand why some people develop conditions like MS and NP-SLE.
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Preventing Suicide Among Teens Who Use Substances in School Settings
Aims to see if how schools respond to substance-use incidents (like alcohol or drugs) can lower suicide risk among high‑risk students.
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TREM2 in microglia and Alzheimer’s disease
Researchers are studying how brain immune cells called microglia, via the TREM2-DAP12 pathway, influence Alzheimer’s disease and how to better use this biology to help people with dementia.
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Gene Therapy Network: Expert Guidance for Rare Neurological Gene Treatments
A specialized group will guide early gene therapy trials for ultra-rare neurological disorders to help adults and children who currently have few or no options.
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Understanding how bacterial communication drives infections and how a new anti-virulence compound could help
A researcher at a major hospital is studying how bacteria talk to each other to cause infections and whether a promising anti-virulence compound can disrupt that communication to reduce disease.
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Tesamorelin with Exercise to Improve Function in HIV Patients
A new plan adds tesamorelin to an exercise program to help people living with HIV move better and stay stronger.
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Oxytocin as a Therapy to Help Adolescents and Young Adults with Obesity
A study tests whether nasal oxytocin can help reduce weight and improve metabolic health in teens and young adults with obesity.
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Understanding RSV blockers: how vaccines and antibodies work against different RSV strains
Researchers are studying how RSV vaccines and antibody medicines interact with the virus’s changing forms to improve protection for people of all ages.
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Disulfiram/Copper as a new approach to making chordoma more treatable
A study tests a drug combo to help people with chordoma by making tumor cells and immune cells easier to target and by boosting how well radiation and PD-1 therapies work.
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Toward safer, more affordable MRI for everyone
A new engineering approach aims to make high‑performance MRI cheaper and easier to use outside big hospitals, so people in rural areas or in developing countries can get better imaging.
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NeuroPASS: a refillable cranial drug-delivery device for glioblastoma patients
A new refillable device implanted in the skull delivers cancer-fighting drugs to people with recurrent glioblastoma.
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NUZ-001: a treatment option for ALS to protect nerve cells
A small molecule called NUZ-001 is being tested to help people with ALS by improving cell systems that keep proteins balanced and prevent harmful protein clumps.
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Improving how vectored antibodies fight HIV
A study tests enhanced antibody-based protection against HIV by delivering genes that keep protective antibodies present in the body.
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Innovative brain technology to help people with treatment-resistant depression at home
A new, small implantable brain stimulator aims to deliver personalized, at-home therapy for people with treatment-resistant depression who have not benefited from standard treatments.
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Neurava epilepsy risk forecasting with wearable data
A study using wearable data and machine learning to forecast SUDEP risk in adults with epilepsy who have refractory seizures.
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Brain ultrasound and microcirculation to understand early brain development in HIV-exposed uninfected infants
We’re studying how brain ultrasound and blood flow patterns in newborns exposed to HIV and antiretroviral drugs (but not infected) relate to their early neurodevelopment.
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Wearable home-use device to help children with cerebral palsy walk better
A home-friendly ankle exoskeleton worn by children with cerebral palsy aims to improve walking by delivering real-time biofeedback and targeted training.
Quick answers
How many clinical trials run by Massachusetts General Hospital are recruiting right now?
355, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 14 countries. The most sites are in United States (347 trials), South Africa (5 trials), Italy (3 trials), Canada (2 trials), Australia (2 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 54, Phase 4: 22, Phase 1: 19, Early Phase 1: 12. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.