Giving adults their genetic risk score for coronary artery disease to see if it changes heart health.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The PROACT 3 trial randomizes 500 adults aged 30–75 who receive primary care within the Mass General Brigham network and are not taking LDL-lowering medications. All participants undergo a polygenic risk score test for coronary artery disease and are assigned 1:1 to immediate disclosure of results or deferred disclosure after about 12 months. The primary outcome is change in LDL cholesterol from baseline to 12 months, and secondary outcomes include change in the American Heart Association Life's Essential 8 score plus measures of engagement with preventive care (lipid panels, blood pressure checks, primary care visits, and initiation of preventive therapies). The single-center trial uses electronic health record queries to identify eligible patients and is conducted at Massachusetts General Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Current age 30-75 years
* Established primary care at Mass General Brigham with at least one visit in the last 2 years

Exclusion Criteria:

\- Currently taking LDL cholesterol- lowering medications, including statins

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Roukoz Karam, MD
• Email: proact@mgb.org
• Phone: 6174121147

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.