Transplanting patients' own stem cells to treat Parkinson's disease

Phase I Trial of Autologous Induced Pluripotent Stem Cell-derived Dopaminergic Progenitor Cell Transplantation for Parkinson's Disease

This study is testing if transplanting patients' own stem cells from their skin into their brains can safely help treat Parkinson's disease.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 8 (estimated)
• Ages: 45 Years to 80 Years
• Sex: All
• Sponsor: Massachusetts General Hospital (Academic / other)
• Locations: 1 site (Boston, Massachusetts)
• Trial ID: NCT06687837 on ClinicalTrials.gov

What this trial studies

This Phase I clinical trial aims to evaluate the safety and tolerability of transplanting dopaminergic progenitor cells derived from participants' own skin cells into their brains to treat Parkinson's disease. Participants will undergo a surgical procedure where these cells will be bilaterally implanted into the putamen under general anesthesia. The study will monitor the participants over a 2-year period using clinical assessments and neuroimaging techniques such as CT, MRI, and 18F-DOPA PET to ensure the procedure's safety and effectiveness.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 45 to 80 with a diagnosis of Parkinson's disease who have had motor symptoms for at least 5 years and experience significant 'off' time despite medication.

Not a fit: Patients with early-stage Parkinson's disease or those who do not respond to dopaminergic medications may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide a novel treatment option that may improve motor function in patients with Parkinson's disease.

How similar studies have performed: While the approach of using autologous stem cells is innovative, similar studies have shown promise in preclinical models, but this specific method is still largely untested in human subjects.

Eligibility criteria

Inclusion Criteria:

* Diagnosis of Parkinson's Disease consistent with the Movement Disorders Society 2015 Parkinson's diagnostic criteria.
* Age 45 - 80 years
* English proficiency sufficient to understand the consent form and participate in a discussion of risks and benefits
* At least 5 years since Parkinson's disease motor symptom onset
* Modified Hoehn and Yahr stage 3-4 in "off"-medication state
* Motor symptoms responsive to levodopa and/or dopamine agonist, defined as taking at least 300 mg/day of levodopa and exhibiting improvement between "off" and "on" MDS-UPDRS of at least 30%
* At least 3 hours of cumulative "off" time per day
* Stable regimen of Parkinson's medications, including levodopa and dopamine agonists, for at least 4 weeks prior to screening.
* Acceptable surgical laboratory values including:

  1. Platelets \> 100×109/L (transfusion independent)
  2. Prothrombin time / partial thromboplastin time in normal range and international normalized ratio ≤ 1.3
  3. Aspartate aminotransferase and alanine aminotransferase \< 2.5x the upper limit of normal
  4. Serum creatinine ≤ 1.5mg/dL
  5. White blood cell count \< 12×109/L.
  6. Estimated glomerular filtration rate ≥ 30 mL/min/1.73m2
* Subject agrees to defer elective neurological surgery, including deep brain stimulation or lesional procedure for PD, invasive treatments, including levodopa or apomorphine infusion, or pump- pump-administered levodopa intestinal gel, until after the study's primary outcome is completed.
* Findings on baseline 18F-DOPA PET imaging consistent with dopaminergic denervation of the putamen
* Subject is willing and able to comply with all study visits and procedures in the opinion of the Investigator.

Exclusion Criteria:

* Subjects unable to give consent due to dementia or psychosis.
* Montreal Cognitive Assessment (MoCA) score \< 26
* Subjects with a first-degree relative with Parkinson's disease or with a known genetic mutation predisposing to the development of Parkinson's disease (i.e. this initial study is confined to the more common "sporadic" vs a "genetic" form of the disease).
* Atypical Parkinsonism (Parkinson's-Plus syndrome, secondary parkinsonism)
* Moderate or severe levodopa-induced dyskinesias in any body segment (such patients were found to be more prone to graft-induced dyskinesias in the fetal tissue studies that are proof of priniciple for this therapy)
* Neurologic history or imaging demonstrating brain pathology not directly related to Parkinson's disease that is likely to interfere with study compliance or assessment of Parkinson's related motor disability.
* History of stroke or transient ischemic attack
* History of subarachnoid hemorrhage
* Presence or history of psychosis within 12 months of screening
* Suicidal ideation associated with intent or plan in the past 12 months (an answer of "yes" to C-SSRS questions 4 or 5) or with a previous history of suicide attempts in the past 5 years.
* History of intracranial surgery including deep brain stimulation, focused ultrasound, stereotactic or radiosurgical lesion therapy
* History of malignancy within 5 years. Exceptions will be made for treated cutaneous squamous cell or basal cell carcinoma without evidence of metastasis.
* Use of anticoagulation / antiplatelet agents that cannot be stopped for one week in advance of and two days following surgery without significant risk to the subject
* Use of chronic immunosuppressive therapy including chronic steroids
* Contraindication to MRI or MRI contrast agents
* Pregnant or nursing women
* Subjects with active cardiovascular and cerebrovascular disease within 6 months prior to signing the informed consent form.
* History of severe heart failure (congestive heart failure of New York Heart Association Class II or above or left ventricular ejection fraction \< 35% by any examination method), unstable angina pectoris and myocardial infarction/
* Severe arrhythmia
* History of cardiovascular surgery (cardiac, vascular stent surgery, angioplasty)
* Patients with major vascular diseases (aortic aneurysm, aortic dissecting aneurysm, internal carotid artery stenosis)
* Hypertensive patients with poorly controlled blood pressure (defined as blood pressure consistently above 160/100 mmHg despite treatment with antihypertensive drugs) and patients with severe postural hypotension
* Diabetic patients with poorly controlled blood glucose (glycosylated hemoglobin \> 9.0%, or fasting plasma glucose (FPG) ≥ 11.1 mmol/L);
* Subjects with alcohol or drug addiction

Where this trial is running

Boston, Massachusetts

• Massachusetts General Hospital — Boston, Massachusetts, United States (Recruiting)

Study contacts

• Study coordinator: Jeffrey S Schweitzer, MD, PhD

Conditions Parkinson Disease