Symptom monitoring with feedback to help advanced CKD patients feel better
Official title: Use of an Electronic Patient-Reported Outcome Measure for Symptom Monitoring With Supported Feedback in Advanced Chronic Kidney Disease
Run by Massachusetts General Hospital · NCT07186218 · Data updated 2026-11-12
A small, 70-person trial will test whether regularly asking patients to report CKD symptoms and sharing those results with clinicians can improve quality of life and symptom burden.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | June 11, 2026 |
| Main results expected | July 2029 |
| Study ends | February 28, 2030 |
| Registry record updated | June 22, 2026 |
| Trial ID | NCT07186218 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 or older with advanced CKD (eGFR ≤ 30 mL/min/1.73 m2 on two occasions at least 90 days apart) under nephrology care at Mass General Brigham who can read English and consent.
✕Probably not a fit
Patients who do not experience meaningful symptom changes or who have complex comorbidities limiting potential HRQOL gains may see minimal or no benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, open-label randomized pilot study enrolling 70 adults with advanced CKD (eGFR ≤ 30) to compare electronic patient-reported outcome monitoring (IPOS-Renal ePROM) plus clinician feedback against standard care. Participants will complete the IPOS-Renal survey monthly for 12 months; clinicians will receive feedback and symptom-management guidance, but treatment decisions remain at the clinician’s discretion. The study aims to assess reach, feasibility, acceptability, and preliminary efficacy of integrating PROMs into routine nephrology care. Outcomes will focus on symptom burden and health-related quality of life, with attention to implementation practicality in a real-world clinic setting.
Why it matters
Potential benefit: If successful, this approach could help clinicians address CKD symptoms more effectively and improve patients’ quality of life.
How similar studies have gone: Previous PROM-based efforts in CKD have shown promise for improving symptom awareness, with ongoing research to optimize integration into care.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (age ≥ 18 years) * Advanced CKD, defined as at least two measurements of creatinine-based or cystatin C-based eGFR ≤ 30 mL/min/1.73m2 separated by at least 90 days in the preceding 12 months * Able to provide consent to participate in the study * Able to read and write in English * Under the care of a nephrologist at a Mass General Brigham nephrology clinic Exclusion Criteria: * Terminal illness likely to lead to death within 6 months of participation * Patients receiving dialysis treatment at the time of enrollment or scheduled to start dialysis therapy in the next 4 weeks * Patients scheduled to receive a kidney transplant in the next 6 months * Patients having their initial clinic visit (i.e., new to the clinic) * Cognitive deficits that would preclude understanding of consent form and/or questionnaires
Where it's running
-
Mass General Brigham
Boston, Massachusetts, United States Recruiting
Study contacts
- Study coordinator: Kendra Wulczyn, MD, MPH
- Email: kwulczyn@mgb.org
- Phone: 617-726-5050
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.