A brief nurse-delivered program plus a digital app to help with breathlessness in advanced lung cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multi-site interventional study will test the BREEZE+ dyspnea intervention, consisting of three brief nurse-delivered sessions and access to a supportive digital health app, in adults with advanced lung cancer experiencing moderate to severe breathlessness. The goal is to determine if this approach improves dyspnea and related quality of life compared with enhanced usual care, and to lay the groundwork for integrating the program into standard oncology care. Participants must have advanced lung cancer, be 18 or older, and report at least moderate breathlessness, with preserved functional status (ECOG 0-2) and ability to read English or Spanish. The study is led by Massachusetts General Hospital with collaboration from the University of Miami and the National Cancer Institute, and will enroll participants at both sites. The intervention addresses psychological as well as physiological contributors to dyspnea and aims to reduce health care utilization related to breathlessness.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Diagnosis of advanced lung cancer (i.e., non-small cell lung cancer or small cell lung cancer) or mesothelioma, not being treated with curative intent
* Self-report at least moderate dyspnea per a rating ≥4 on the validated 0-10 breathlessness item of the Edmonton Symptom Assessment Scale-Revised
* Functioning independently per an Eastern Cooperative Oncology Group Performance Status ≤2
* Ability to read and respond to questions in English or Spanish
* Receiving primary cancer care at one of the participating institutions

Exclusion Criteria:

* Significant uncontrolled psychiatric disorder or other co-morbid disease (e.g., dementia, cognitive impairment), which the treating oncology clinician reports would prohibit the patient's ability to participate in study procedures.

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting
• University of Miami
  Coral Gables, Florida, United States Not yet recruiting

Study contacts

• Study coordinator: Jennifer S. Temel, MD
• Email: jtemel@mgh.harvard.edu
• Phone: 617-724-4000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.