Colorectal cancer screening for unscreened people aged 45–54
Official title: Initiating Colorectal Cancer Screening in Unscreened Individuals 45 to 54
Run by Massachusetts General Hospital · NCT06757192 · Data updated 2026-11-12
This project will try to find what helps or gets in the way of colorectal cancer screening for patients aged 45–54 at community health centers by talking with patients and staff and linking staff survey results to clinic records.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 45 Years to 54 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | June 16, 2025 |
| Main results expected | August 31, 2029 |
| Study ends | August 31, 2029 |
| Registry record updated | November 13, 2025 |
| Trial ID | NCT06757192 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 45–54 who receive care at the participating community health centers, have not completed colorectal cancer screening, and can give verbal or written consent.
✕Probably not a fit
People with a personal or family history of colorectal cancer, inflammatory bowel disease, high-risk cancer syndromes, or those who have already completed screening are excluded and are unlikely to benefit from this observational work.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational, mixed-methods project uses the CFIR implementation framework to identify system-level determinants of colorectal cancer screening in unscreened patients aged 45–54. The team will conduct a validated organizational survey with staff and providers at Codman Square Health Center and nine partner community health centers and link those survey responses to patient-level electronic health record data. Researchers will also do one-time in-depth interviews with patient-facing community health center staff, providers, and patients, with interviews conducted online or in person. Findings will be used to map barriers and facilitators within clinic systems that influence screening completion.
Why it matters
Potential benefit: If successful, the findings could help clinics change processes to increase screening rates and detect colorectal cancer earlier in people aged 45–54.
How similar studies have gone: Previous implementation and CFIR-based studies have identified clinic-level barriers to screening and supported targeted improvements in some settings, so the approach has precedent.
Who can join: the full rules
Show full inclusion / exclusion criteria
PATIENTS Inclusion Criteria: * Individuals aged 45-54 * Individuals who are patients at the health center * Individuals that are willing and able to give verbal/written consent Exclusion Criteria: * Individuals with a personal history of CRC * Individuals with a family history of CRC * Individuals with a history of inflammatory bowel disease or high-risk cancer syndrome STAFF Inclusion Criteria: * Individuals ages 18+ * Individuals working at the health center * Individuals that are involved in CRC screening processes at CSHC * Individuals that are willing and able to give verbal/written consent
Where it's running
-
Codman Square Health Center
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Adjoa Anyane-Yeboa, MD, MPH — Massachusetts General Hospital
- Study coordinator: Adjoa Anyane-Yeboa, MD, MPH
- Email: aanyane-yeboa@mgh.harvard.edu
- Phone: (617) 726-6609
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Electrolyte beverage plus PEG for colonoscopy bowel prep
This randomized trial tests different mixes of electrolyte drink and water with PEG to see which bowel prep regimen gives the best cleansing for adults getting colonoscopy.
-
Using prior CT scans to guide colonoscope insertion
This trial will test whether using a patient's existing abdominal/pelvic CT scan to guide colonoscope insertion makes colonoscopy faster and more comfortable for adults having screening or diagnostic colonoscopy.
-
Animated storytelling video to boost colorectal cancer screening
A short animated video is being tested to see if it makes adults in the U.S. who haven’t been screened more likely to plan getting screened for colorectal cancer.
-
Does GP endorsement and early information improve colonoscopy follow-up after a positive colorectal cancer screening test?
This study tests whether giving patients early information about colonoscopy and having their GP endorse the follow-up can increase how many people in France get a colonoscopy within six months after a positive screening result.
-
Pilot of a colorectal cancer education program
This program will test whether a culturally and language‑targeted education program helps adults aged 45–75 who are overdue for colorectal cancer screening complete recommended screening.
-
Noninvasive blood miRNA test to screen for multiple gastrointestinal cancers.
This project will test whether a blood-based microRNA panel can detect several types of gastrointestinal cancer in adults using stored blood samples.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.