Colorectal cancer screening for unscreened people aged 45–54

Initiating Colorectal Cancer Screening in Unscreened Individuals 45 to 54

Observational Massachusetts General Hospital · NCT06757192

This project will try to find what helps or gets in the way of colorectal cancer screening for patients aged 45–54 at community health centers by talking with patients and staff and linking staff survey results to clinic records.

Quick facts

Study typeObservational
Enrollment40 (estimated)
Ages45 Years to 54 Years
SexAll
SponsorMassachusetts General Hospital Academic / other
Locations1 site (Boston, Massachusetts)
Trial IDNCT06757192 on ClinicalTrials.gov

What this trial studies

This observational, mixed-methods project uses the CFIR implementation framework to identify system-level determinants of colorectal cancer screening in unscreened patients aged 45–54. The team will conduct a validated organizational survey with staff and providers at Codman Square Health Center and nine partner community health centers and link those survey responses to patient-level electronic health record data. Researchers will also do one-time in-depth interviews with patient-facing community health center staff, providers, and patients, with interviews conducted online or in person. Findings will be used to map barriers and facilitators within clinic systems that influence screening completion.

Who should consider this trial

Good fit: Ideal candidates are patients aged 45–54 who receive care at the participating community health centers, have not completed colorectal cancer screening, and can give verbal or written consent.

Not a fit: People with a personal or family history of colorectal cancer, inflammatory bowel disease, high-risk cancer syndromes, or those who have already completed screening are excluded and are unlikely to benefit from this observational work.

Why it matters

Potential benefit: If successful, the findings could help clinics change processes to increase screening rates and detect colorectal cancer earlier in people aged 45–54.

How similar studies have performed: Previous implementation and CFIR-based studies have identified clinic-level barriers to screening and supported targeted improvements in some settings, so the approach has precedent.

Eligibility criteria

Show full inclusion / exclusion criteria
PATIENTS

Inclusion Criteria:

* Individuals aged 45-54
* Individuals who are patients at the health center
* Individuals that are willing and able to give verbal/written consent

Exclusion Criteria:

* Individuals with a personal history of CRC
* Individuals with a family history of CRC
* Individuals with a history of inflammatory bowel disease or high-risk cancer syndrome

STAFF

Inclusion Criteria:

* Individuals ages 18+
* Individuals working at the health center
* Individuals that are involved in CRC screening processes at CSHC
* Individuals that are willing and able to give verbal/written consent

Where this trial is running

Boston, Massachusetts

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Colorectal Cancer Screeningcolorectal cancer screening
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.