Tracking family members at risk for inflammatory bowel disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows unaffected first-degree relatives of individuals with inflammatory bowel disease (IBD) to assess their risk of developing the condition. Participants will complete annual questionnaires and provide blood, stool, and urine samples to identify behaviors, dietary factors, and biomarkers that may predict the onset of IBD. The study aims to gather data over approximately 10 years to explore potential prevention strategies for high-risk individuals. Some assessments can be done from home, while blood draws will occur at Massachusetts General Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ability to give informed consent
* Ability to complete all study visits and study-related procedures
* Ability to understand and complete study questionnaires
* Must have at least one first-degree relative with inflammatory bowel disease (Crohn's disease, ulcerative colitis, or IBD-unclassified)
* Age ≥ 14

Exclusion Criteria:

* Individuals with existing diagnoses of inflammatory bowel disease (ulcerative colitis, Crohn's disease, or IBD-unclassified)
* Evidence of clinical signs or symptoms of IBD, which will be identified on pre-screening interview with the study coordinator.

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Emily W Lopes, MD, MPH — Massachusetts General Hospital
• Study coordinator: Emily W Lopes, MD, MPH
• Email: mghfindibd@mgb.org
• Phone: 617-726-5560

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Personalized Crohn's risk estimator (PRE-Crohn's) implementation and feasibility

  This project will test a web-based personalized risk tool to see if giving unaffected first-degree relatives of people with Crohn's disease tailored risk information changes their behaviors and early disease markers.

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• Switching to guselkumab for adults with active IBD after ustekinumab

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• Zymfentra (infliximab-dyyb) real-world cohort

  This project will see if Zymfentra (infliximab-dyyb) reduces symptoms over one year in adults with Crohn's disease, ulcerative colitis, or indeterminate colitis who are starting or switching to the drug as part of routine care.

  Recruiting at 11 sites University of North Carolina, Chapel Hill · New Haven, Connecticut and 10 other locations · NCT07237516

• SMART-IBD app for teens with inflammatory bowel disease

  This will test whether the SMART-IBD smartphone app helps adolescents ages 13–17 with IBD take their medicines and manage symptoms better than completing daily diaries alone.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07195123

• Wearable data to spot IBD flareups in people with ulcerative colitis or Crohn's disease

  This study tests whether heart‑rate variability from participants’ own wearables can help predict IBD flares.

  Recruiting at 2 sites Maastricht University Medical Center · 's-Hertogenbosch and 2 other locations · NCT07647640

• DISC-0974-201 for adults with IBD-related anemia

  This Phase 2 trial will test whether DISC-0974-201 helps adults with inflammatory bowel disease who have anemia driven by inflammation.

  Recruiting at 15 sites Phase 2 Disc Medicine, Inc · Birmingham, Alabama and 14 other locations · NCT07368972

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.