Non-contrast CT V: See If CT has a Role in Finding Pulmonary Embolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will add two very low-dose CT image acquisitions during a standard evaluation for suspected PE to see if non-contrast imaging can reveal emboli. Participants will blow into a spirometer to practice breath-holding and will be monitored briefly, totaling about 5 minutes of participation. Medical records may be reviewed for 30 to 90 days after the CT scan. The main risks are radiation exposure and minor spirometer-related discomfort.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients undergoing CTPA for suspected aPE
2. Patients who provide written informed consent to participate
3. Adults patients \>/= 21 years of age
4. Mini Mental State Exam (MMSE) score of 18 or more.

Exclusion Criteria:

1. Patients who decline informed consent
2. Patients with known chronic PE
3. Patients with known interstitial lung diseases
4. Patients who cannot raise their arms above their shoulders (arms can cause serious artifacts)
5. Women of child-bearing potential (\< 55 years) who test positive for pregnancy test
6. Patients \< 21 years of age (to avoid research radiation dose in young patients)
7. Patients with any EMR documented cognitive impairment or diseases such as dementia, recent head injury, psychiatric disorders, or other neurological diseases that impair decision-making.
8. Pregnant subjects
9. Women of child-bearing potential (21-55 years) who refuse to take a urine pregnancy test prior to their CT examination
10. Mini Mental State Exam (MMSE) score of less than 18.

Where it's running

• Massachusetts General Hospital/Harvard Medical School
  Boston, Massachusetts, United States Recruiting
• Massachusetts General Hospital
  Boston, Massachusetts, United States Not yet recruiting

Study contacts

• Study coordinator: Shivangi JHA, MD, MPH
• Email: sjha7@mgh.harvard.edu
• Phone: 16176434583

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.