Brillouin hydration mapping to study cornea health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study seeks to develop and validate Brillouin-based hydration mapping as a noninvasive way to quantify water content in the cornea. The goal is to create a clinically viable method that could aid in early detection and better management of corneal diseases and postoperative issues. The approach relies on spatially resolved Brillouin frequency shifts to reflect hydration independently of corneal thickness. Participants include healthy volunteers and patients with conditions such as Fuchs endothelial corneal dysfunction, open-angle glaucoma, dry eye disease, keratoconus, and prior LASIK surgery. The study is conducted at Massachusetts General Hospital and collaborating centers, with inclusion criteria focused on adults with normal vision or within specific refractive ranges and without recent ocular surgeries or active systemic diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy volunteers with normal eyes
* Visual acuity between +2 to -6 diopters

Exclusion Criteria:

* History of refractive or cataract surgery
* History of ocular disease
* Active non-ophthalmic systemic disease

Where it's running

• Massachusetts General Brigham
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Seok-Hyun Yun, PhD — Massachusetts General Brigham
• Study coordinator: Soyeon (Selina) Ahn, PhD
• Email: sahn14@mgh.harvard.edu
• Phone: 3396009736

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.