Nitric Oxide Use to Predict Vasospasm in Aneurysmal Subarachnoid Hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares nitric oxide consumption in CSF between SAH patients and non-SAH controls to see if NO levels relate to the development of angiographic cerebral vasospasm. CSF samples are collected daily from SAH patients with EVD for up to 15 days and stored for analysis, while routine monitoring for vasospasm is conducted with transcranial Doppler and CT angiography as indicated. A control group consists of individuals without SAH undergoing procedures with CSF sampling. After data collection, participants are categorized into SAH with vasospasm, SAH without vasospasm, and controls to explore associations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult
* patient with SAH and with an external ventricular drainage (EVD) placed within 24 hours after the onset of the hemorrhage

Exclusion Criteria:

* pregnancy
* pre-existing neurological comorbidities
* coagulation disorders
* anemia
* absence of a good cranial window to perform Transcranial Doppler (TDC)
* presence of \>50% stenosis of carotid arteries confirmed by doppler ultrasound
* Technical problems on EVD that prevent CSF withdrawals

For the control group, we will invite to participate patients without neurological comorbidities undergoing spinal anesthesia in the operating room or with a spinal drain for major vascular surgery.

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting
• Fondazione Policlinico Universitario Agostino Gemelli
  Rome, Italy Recruiting

Study contacts

• Principal investigator: Lorenzo Berra, MD — Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
• Study coordinator: Lorenzo Berra, MD
• Email: lberra@mgh.harvard.edu
• Phone: 617-726-3030

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.