Tesamorelin with Exercise to Improve Function in HIV Patients
Official title: Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH)
Funded at Massachusetts General Hospital · NIH-11575468 · Data updated 2026-11-12
A new plan adds tesamorelin to an exercise program to help people living with HIV move better and stay stronger.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $184,800 |
| NIH project number | 3R01AG087809-03S1 |
| Project ID | NIH-11575468 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HIV who are able to participate in an exercise program and meet safety criteria.
✕Less likely to help
Individuals unable to exercise or with conditions that contraindicate tesamorelin may not benefit.
What this research studies
This grant tests whether adding tesamorelin, a hormone-related medication, to a standard exercise program can improve physical function and reduce frailty in adults with HIV. The study builds on prior findings that people with HIV may not respond as well to exercise and often struggle to stay adherent over time. If tesamorelin helps, it could make exercise benefits last longer and be easier to maintain in daily life. The project is conducted at Massachusetts General Hospital with careful monitoring for safety and effectiveness.
Why it matters
Potential benefit: If successful, the approach could improve daily functioning and quality of life for people with HIV who face aging-related physical declines.
How similar studies have gone: Preliminary data suggest hormone-related approaches can enhance exercise responses in HIV, but this combination is being tested for the first time.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Fourman, Lindsay Tara — Massachusetts General Hospital
- Study coordinator: Fourman, Lindsay Tara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.