Imaging study to understand brain function in epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how epilepsy affects brain function by using neuroimaging techniques such as FDG-PET, functional MRI, and EEG. It aims to analyze changes in brain metabolism and blood flow in both healthy individuals and those diagnosed with epilepsy. The study will compare how effectively these imaging modalities can identify regions of abnormal brain function associated with epilepsy. By understanding these relationships, the research seeks to enhance the knowledge of epilepsy's impact on brain activity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 or older

Additional Inclusion Criteria for Subjects with Epilepsy:

* Diagnosed with epilepsy with abnormal interictal EEG

Exclusion Criteria:

* Contraindications to PET, MRI, or EEG imaging
* History of severe brain disease such as stroke and head trauma
* History of brain surgery
* History of type I or II diabetes mellitus
* Fasting plasma glucose level \>200 mg/dL
* Employed under direct supervision of the PI conducting the research

Additional Exclusion Criteria for Healthy Subjects:

* Current use of drugs that modulate brain function
* Current or past history of major medical, neurological, or psychiatric conditions

Where it's running

• Athinoula A. Martinos Center
  Charlestown, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Ciprian Catana, MD, PhD — Massachusetts General Hospital
• Study coordinator: Magdelena S Allen, BA
• Email: mallen27@mgh.harvard.edu
• Phone: 617-724-9232

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.