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Clinical trials and research at Columbia University

• 189Clinical trials
• 3New in 30 days
• 16Countries

Newest trials

All recruiting trials (newest 150 of 189)

• Smartphone-based EEG to detect hidden awareness in ICU patients with brain injuries

  Researchers will test a smartphone-enabled EEG to see if it can reveal Cognitive Motor Dissociation in ICU patients who can’t show commands at bedside.

  Recruiting Columbia University · Miami, Florida and 8 other locations · NCT07917728

• Decision support tools to help high-risk women consider breast cancer chemoprevention

  A web-based decision aid plus standard materials will see if reminders and information help high-risk women start medications like tamoxifen more often.

  Recruiting Columbia University · New York, New York · NCT07899151

• EHR-based approach to boost HBOC genetic testing in at-risk women

  A new EHR tool-based program tests whether computer prompts and real patient resources can help more women with family histories of breast or ovarian cancer get HBOC genetic testing.

  Recruiting Columbia University · New York, New York · NCT07876349

• Preoperative Music to Ease Anxiety Before Hip or Knee Replacement

  Patients awaiting hip or knee replacement listen to their own music through noise‑canceling headphones to see if it lowers preoperative anxiety.

  Recruiting Columbia University · New York, New York · NCT07845695

• Post-Vasectomy Pain Management Aftercare

  This study tests four pain-control regimens after vasectomy to see which helps men feel better and how much pain relief they get.

  Recruiting at 2 sites Phase 1 Columbia University · New York, New York and 1 other locations · NCT07824258

• Sleep patterns to help predict waking from brain injury

  Doctors are testing whether brain activity during sleep can help predict when a person with a serious brain injury will regain awareness.

  Recruiting Columbia University · Miami, Florida and 1 other locations · NCT07794605

• Rapid hydration for severe hypernatremia

  This study tests whether giving fast IV fluids to adults with very high sodium can be done safely and more effectively than standard care.

  Recruiting Phase 2 Columbia University · New York, New York · NCT07783191

• Alpelisib Challenge Test to measure insulin secretory capacity

  Researchers will test a new approach to measure how much insulin the body can produce in people at various weights and with or without insulin resistance, using alpelisib around a meal test.

  Recruiting Phase 1 Columbia University · New York, New York · NCT07778524

• Portable chest X-ray screening to rapidly find TB in migrants

  A community-based TB screening effort using mobile chest X-rays and AI-assisted readings is tested among migrant adults in New York City to see if it helps identify active TB earlier and connect people to care.

  Recruiting Columbia University · New York, New York · NCT07737275

• Comfort Tote to help recovery after scoliosis surgery in teens

  This study tests whether a therapeutic Comfort Tote can reduce pain and anxiety after surgery for adolescent idiopathic scoliosis.

  Recruiting Columbia University · New York, New York · NCT07632833

• Post-op prednisone vs standard steroid regimen after knee or hip replacement

  This study tests a 5-day oral prednisone course after knee or hip replacement to see if pain, swelling, and glucose control are better or different than the usual intraoperative steroid approach.

  Recruiting Phase 4 Columbia University · New York, New York · NCT07630896

• PFO-Directed Therapy for Migraines: Closing the Hole or Using a Blood Thinner

  This study tests whether closing a patent foramen ovale (PFO) plus 24 weeks of prasugrel works better for long-term migraine relief than prasugrel alone in people whose migraines improve on blood-thinning therapy.

  Recruiting Phase 3 Columbia University · New York, New York · NCT07629635

• Columbia Center's Focused Prostate Cancer Treatments Registry

  This registry collects detailed data from men with localized prostate cancer treated with focal therapies (HIFU or IRE) at Columbia to see how these approaches perform in real-world practice.

  Recruiting Columbia University · New York, New York · NCT07623941

• Genome sequencing in pregnancy with normal ultrasound to see if more information helps families

  This study tests whether genome sequencing during pregnancy can provide useful information for families when ultrasounds look normal.

  Recruiting Columbia University · Boston, Massachusetts and 2 other locations · NCT07610590

• Spinal Cord-Targeted Stimulation to Improve Hand Function in Hemiplegic Cerebral Palsy

  This study tests whether pairing hand motor cortex stimulation with median nerve stimulation can boost hand dexterity in adults with hemiplegic cerebral palsy.

  Recruiting Columbia University · New York, New York · NCT07607665

• Dyadic Multidimensional Sleep Health Promotion for Couples

  A couples-focused program tests whether a multidimensional sleep health approach can improve sleep quality and blood pressure in both partners.

  Recruiting Columbia University · New York, New York · NCT07603245

• Dexmedetomidine or Clonidine added to spinal anesthesia for cesarean delivery

  This study tests whether adding dexmedetomidine or clonidine to spinal anesthesia for cesarean delivery improves intraoperative comfort and analgesia.

  Recruiting Phase 4 Columbia University · New York, New York · NCT07567495

• Adaptive mapping of stimulation–response curves with Bayesian modeling

  This project tests a real-time Bayesian method to map how magnetic or electrical stimulation affects muscle responses in healthy adults using fewer measurements.

  Recruiting Columbia University · New York, New York · NCT07561372

• Youth-Nominated Support Team for Probation to prevent suicide in teens

  This pilot tests a program that trains nominated adults to support 12–17-year-olds on probation who are having suicidal thoughts or behaviors, helping them get mental health care and reduce suicide risk.

  Recruiting Columbia University · New York, New York · NCT07559955

• Incretin therapy with tirzepatide for obesity-related HFpEF

  A 15-month study will test whether tirzepatide helps people with obesity and HFpEF by reducing plasma volume.

  Recruiting Phase 4 Columbia University · New York, New York · NCT07554638

• Telehealth-enhanced hybrid cardiac rehabilitation versus clinic-based rehab after an acute coronary syndrome

  This trial tests whether TeleheartCR, a hybrid program combining telehealth, home, and clinic sessions, helps people who had an acute coronary syndrome complete cardiac rehab and improve their fitness as well as traditional clinic-based rehab.

  Recruiting Columbia University · New York, New York · NCT07541014

• Paired brain and wrist nerve stimulation to boost hand motor plasticity in the cervical spinal cord

  This research will test if pairing weak brain stimulation with median nerve stimulation can increase spinal-cord-based plasticity and strengthen hand motor responses in healthy adults.

  Recruiting Columbia University · New York, New York · NCT07539025

• rTMS to improve movement after brain tumor surgery

  This pilot will try whether short courses of daily TMS can help adults with new or ongoing movement weakness after brain tumor surgery recover strength and function.

  Recruiting Columbia University · New York, New York · NCT07530536

• Reducing unnecessary screening mammograms for women 75 and older

  This project tests a multilevel approach to help doctors and patients decide whether to stop routine mammograms for women aged 75 and older.

  Recruiting Columbia University · New York, New York · NCT07511621

• Restoring gut bacteria in adults with chronic heart failure

  This trial tests whether replacing gut bacteria with healthy donor bacteria (intestinal microbiota transplantation) can reduce inflammation and improve function in adults with chronic heart failure.

  Recruiting Phase 1 Columbia University · New York, New York · NCT07490054

• Apixaban vs Warfarin in HeartMate 3 LVAD Patients

  This study tests whether apixaban can replace warfarin to prevent clots and bleeding problems in adults with an implanted HeartMate 3 LVAD for at least 3 months.

  Recruiting Phase 3 Columbia University · New York, New York · NCT07471139

• Aerobic Exercise with Omaveloxolone in Friedreich's Ataxia

  This study tests whether aerobic training combined with omaveloxolone improves fitness and fatigue in people with Friedreich's ataxia.

  Recruiting Columbia University · New York, New York · NCT07444333

• Combining gemcitabine, cisplatin, nab-paclitaxel and cemiplimab to shrink locally advanced biliary tract cancer

  This trial will try whether giving gemcitabine, cisplatin, nab-paclitaxel plus cemiplimab can shrink previously inoperable biliary tract cancers so surgery becomes possible.

  Recruiting Phase 2 Columbia University · New York, New York · NCT07433673

• Brain and spinal cord MRI changes in adults with cerebral palsy

  We will look at past and new brain and spinal cord MRIs to see if adults with cerebral palsy develop brain or spinal cord atrophy over time.

  Recruiting Columbia University · New York, New York · NCT07433647

• Red/near-infrared light to boost egg energy and improve IVF outcomes

  This study will test whether briefly shining red/near-infrared light on eggs during IVF helps them make healthier embryos and raises pregnancy chances for people using their own oocytes.

  Recruiting Columbia University · New York, New York · NCT07425080

• Acceptance- and Mindfulness-Based Exposure Therapy versus Present-Centered Therapy for PTSD after cardiac arrest

  This project will test if Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) or Present-Centered Therapy (PCT) better reduces PTSD symptoms in adults who survived a cardiac arrest.

  Recruiting Columbia University · New York, New York · NCT07410481

• Lowering insulin to reduce liver fat production

  This study will try a short course of diazoxide to lower insulin and see if it reduces the liver's creation of new fat in adults with obesity, insulin resistance, and MASLD.

  Recruiting Phase 1 Columbia University · New York, New York · NCT07403604

• Linking walking patterns to bone strength in ambulatory SMA

  This will try to see if wearable insole gait data can predict bone density and fracture risk in ambulatory people with spinal muscular atrophy who are on disease-modifying therapy.

  Recruiting Columbia University · New York, New York · NCT07400198

• Northera (droxidopa) for dysautonomia in children who survived Menkes disease

  This trial will test whether the oral medicine Northera (droxidopa) is safe and helps reduce fainting, dizziness, low blood pressure, and other dysautonomia symptoms in children and adolescents (ages 7–17) who survived Menkes disease after early copper treatment.

  Recruiting Phase 1/2 Columbia University · New York, New York · NCT07398508

• Patient activation to improve depression care for people with coronary heart disease

  This project will test if the iHeart DepCare tool helps people with coronary heart disease and elevated depressive symptoms start and optimize depression treatment.

  Recruiting Columbia University · New York, New York · NCT07390331

• Impact of Barostim on heart function in adults with reduced ejection fraction

  This trial tests whether implanting and adjusting the Barostim device can improve heart function and exercise ability in adults with HFrEF already taking maximal guideline-directed therapies.

  Recruiting Columbia University · San Francisco, California and 6 other locations · NCT07335510

• Do prenatal effects on baby development occur in IVF pregnancies without shared genes?

  This research will test whether maternal stress during pregnancy affects a baby's brain and behavior even when the mother and baby do not share genes by comparing donor-egg/embryo IVF pregnancies with non-donor IVF pregnancies.

  Recruiting Columbia University · New York, New York · NCT07296107

• Ruxolitinib plus pembrolizumab for relapsed or refractory Hodgkin and non-Hodgkin lymphomas

  This trial will try adding ruxolitinib to pembrolizumab to see if it is safe and helps people whose Hodgkin or non-Hodgkin lymphomas have come back or did not respond to prior treatment.

  Recruiting Phase 2 Columbia University · New York, New York · NCT07283822

• Same-day HPV screen-and-treat for women with HIV in La Romana

  This project will test whether offering same-day HPV screening and immediate treatment improves detection and treatment completion for Spanish-speaking women living with HIV in La Romana, Dominican Republic.

  Recruiting Columbia University · La Romana · NCT07225530

• Pistachios for better sleep in adults with poor sleep

  This study will test whether eating pistachios helps adults who have poor sleep quality sleep better.

  Recruiting Columbia University · New York, New York · NCT07218822

• Preoperative IV iron for teens having spinal fusion to correct scoliosis

  This trial will try giving a single IV iron infusion before spinal fusion to see if it helps 10–19-year-olds with scoliosis and low iron by reducing blood transfusions and improving recovery.

  Recruiting Phase 2/3 Columbia University · New York, New York · NCT07217873

• DELINEATE-Prospective: AI-assisted echocardiogram analysis for valve disease

  This project will test whether an AI system can automatically analyze echocardiograms to help doctors detect valve problems in adults who get heart ultrasounds.

  Recruiting Columbia University · New York, New York · NCT07197736

• Hereditary cancer screening offered during obstetrical carrier screening

  This project will test offering hereditary cancer genetic testing to pregnant and preconception patients who are already getting obstetrical carrier screening to see if they want it and can complete testing alongside routine prenatal care.

  Recruiting Columbia University · New York, New York · NCT07195071

• Trauma-informed obstetric care to support pregnant women with trauma histories

  This project will try trauma-informed obstetric care training for clinicians to see if it helps pregnant women with past trauma improve prenatal mental health and early bonds with their babies.

  Recruiting Columbia University · Buenos Aires, Buenos Aires F.D. · NCT07195058

• Long COVID relief through learning mindfulness

  This study will try an 8-week online recorded mindfulness program to see if it reduces stress and Long COVID symptoms in adults who continue their usual care.

  Recruiting Columbia University · New York, New York · NCT07140094

• Cost Effective Air Filtration for Kids’ Asthma in NYC Housing

  Aiming to see if a cost-effective HEPA air cleaner used in homes of children with asthma in NYC can lower indoor pollution and improve asthma symptoms.

  Recruiting Columbia University · New York, New York · NCT07116460

• Teclistamab plus daratumumab for newly diagnosed AL amyloidosis

  This tests whether combining teclistamab with daratumumab is safe and helps people newly diagnosed with AL amyloidosis by lowering harmful light chains and protecting organ function.

  Recruiting at 2 sites Phase 2 Columbia University · Boston, Massachusetts and 2 other locations · NCT07110844

• Letermovir versus valganciclovir to prevent CMV after heart transplant

  This trial will test whether letermovir or valganciclovir better prevents CMV viremia in adults at moderate-to-high CMV risk after a heart transplant.

  Recruiting at 2 sites Phase 2/3 Columbia University · New York, New York and 1 other locations · NCT07079735

• 131I-apamistamab conditioning for stem cell transplant in advanced sickle cell disease

  This trial tries to see if a targeted radioactive antibody (131I-apamistamab) can be used as the pre-transplant conditioning to prepare people aged 12–50 with advanced sickle cell disease and an HLA-matched sibling donor for an allogeneic stem cell transplant.

  Recruiting Phase 1 Columbia University · New York, New York · NCT07015684

• Understanding fatigue in patients with spinal muscular atrophy treated with nusinersen

  This study is trying to see how nusinersen treatment affects fatigue in people with spinal muscular atrophy and how that fatigue impacts their daily activities.

  Recruiting Columbia University · New York, New York · NCT06955897

• Evaluating treatment options for posttransplant lymphoproliferative disorder

  This study is testing a combination of rituximab and chemotherapy for patients with high-risk posttransplant lymphoproliferative disorder to see if it helps them better than just using rituximab alone.

  Recruiting Phase 2 Columbia University · Stanford, California and 1 other locations · NCT06954805

• Helping young cancer survivors with financial and social needs

  This study is testing a new digital tool to help young cancer survivors manage their financial and social needs better than the usual care.

  Recruiting Columbia University · New York, New York · NCT06950983

• Using droxidopa to improve kidney function in patients with liver cirrhosis and kidney injury

  This study is testing if an oral medication called droxidopa can help improve kidney function and blood pressure in hospitalized patients with liver cirrhosis and kidney injury.

  Recruiting Phase 2 Columbia University · New York, New York · NCT06937307

• R-MVST cell therapy for viral infections in children and young adults

  This will try giving rapidly generated virus-specific T cells (R-MVST) to children and young adults whose weakened immune systems have recurrent or treatment-resistant infections with EBV, CMV, adenovirus, or BK virus.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06926894

• Cash support for improving maternal and child health

  This study tests if giving cash support to pregnant women can improve their health and their babies' growth in the U.S.

  Recruiting Columbia University · New York, New York · NCT06923371

• Using brain stimulation to improve cognitive symptoms in Lyme disease patients

  This study is testing if combining brain stimulation with at-home cognitive training can help people with Lyme disease improve their thinking skills after treatment.

  Recruiting at 2 sites Columbia University · San Francisco, California and 1 other locations · NCT06915324

• Treatment of superficial lipomas using radiofrequency ablation

  This study is testing if a new heat treatment called radiofrequency ablation can safely remove small fatty tumors called lipomas without causing scars for adults.

  Recruiting Columbia University · New York, New York · NCT06903208

• IT-guided HIV screening and prevention in dental clinics

  This project will test whether an electronic alert plus either the usual dental team or an added care navigator helps dental teams offer HIV testing and prevention to dental patients.

  Recruiting Columbia University · New York, New York and 2 other locations · NCT06890988

• Long-term safety of Imatinib for patients with Lymphangioleiomyomatosis

  This study is testing if the cancer drug Imatinib is safe and can help women with Lymphangioleiomyomatosis by seeing how it affects their lung health over time.

  Recruiting at 2 sites Phase 1 Columbia University · New York, New York and 1 other locations · NCT06889168

• Tail-PrEP: Safe, guided stopping of long-acting PrEP with coaching and monitoring

  This study tests whether monthly HIV prevention coaching and drug-level monitoring can help people stop long-acting cabotegravir or switch to safer options without increasing HIV risk.

  Recruiting Columbia University · New York, New York · NCT06868641

• Spine and brain stimulation to restore arm and hand movement after cervical spinal cord injury.

  This will try temporary cervical spinal cord electrical stimulation together with noninvasive brain stimulation to improve arm and hand movement in adults with chronic incomplete cervical spinal cord injury.

  Recruiting at 2 sites Columbia University · New York, New York and 1 other locations · NCT06867809

• See if PrEP for WINGS helps with starting and sticking to PrEP among women in community supervision programs

  This study tests PrEP for WINGS plus PrEP compared with PrEP alone to see if it increases PrEP initiation and adherence among cisgender women in CSPs who use alcohol hazardously and may face IPV and HIV risk.

  Recruiting Columbia University · New York, New York · NCT06853314

• Impact of ultra processed food on energy storage in the body

  This study is testing how eating mostly ultra processed foods affects energy storage in people with obesity.

  Recruiting Columbia University · New York, New York · NCT06853288

• Identifying walking-related digital biomarkers in rare childhood neuromuscular disorders

  This study is testing if special insoles with sensors can help track walking patterns in kids with spinal muscular atrophy or Duchenne muscular dystrophy to better understand their mobility.

  Recruiting at 3 sites Columbia University · Palo Alto, California and 2 other locations · NCT06839469

• Ketamine vs Morphine for Acute Pain in Children

  In kids with acute pain in the emergency department, researchers are testing whether sub-dissociative ketamine can treat pain as well as morphine and with fewer side effects.

  Recruiting at 4 sites Phase 3 Columbia University · Los Angeles, California and 7 other locations · NCT06835504

• Evaluating heart recovery with Impella 5.5 in severe heart failure patients

  This study is testing how well the Impella 5.5 heart device helps people with severe heart failure recover after a heart attack.

  Recruiting Columbia University · New York, New York · NCT06800716

• Anxiety during abstinence in people with alcohol use disorder

  This project will test whether anxiety and related brain activity change from early to three months of abstinence in people with alcohol use disorder who take disulfiram, compared with healthy volunteers.

  Recruiting Early Phase 1 Columbia University · New York, New York · NCT06793488

• Increasing HIV Testing and Prevention for Black Gay and Bisexual Men

  This study is testing a new approach to help Black gay and bisexual men in New York City get more HIV tests and access prevention methods like PrEP to improve their health.

  Recruiting Columbia University · New York, New York · NCT06785376

• Digital strategies to improve help-seeking for youth at risk of psychosis

  This study is testing new digital tools to help young people aged 12-29 who are at risk for psychosis find the support they need and start treatment faster.

  Recruiting Columbia University · New York, New York · NCT06774430

• Digital tools to help youth seek care sooner when at risk for psychosis

  This project will test personalized digital messages and online strategies to help people ages 12–29 who screen positive for psychosis risk find and start local care sooner.

  Recruiting Columbia University · New York, New York · NCT06774417

• Using a mobile app to reduce HIV infections in young men and non-binary individuals

  This study is testing a mobile app designed to help young men and non-binary individuals reduce their risk of getting HIV.

  Recruiting at 2 sites Columbia University · Chicago, Illinois and 1 other locations · NCT06741631

• Mobile intervention for HIV prevention in young men who have sex with men

  This study is testing a mobile program that helps young men who have sex with men learn about and access HIV prevention methods, like PrEP, to see if it can reduce their risk of getting HIV.

  Recruiting Columbia University · New York, New York · NCT06741618

• Injectable versus sublingual buprenorphine for people using fentanyl and other potent synthetic opioids

  This project will test whether a long-acting injectable buprenorphine or daily sublingual buprenorphine/naloxone works better at reducing drug use and preventing relapse in adults who use fentanyl or other high‑potency synthetic opioids.

  Recruiting Early Phase 1 Columbia University · New York, New York · NCT06726200

• Evaluating the effects of hypoglossal nerve stimulation on metabolism in sleep apnea patients

  This study is testing if a therapy that stimulates a nerve in the tongue can help people with sleep apnea improve their metabolism and reduce health risks.

  Recruiting Columbia University · New York, New York · NCT06720545

• Cervical spinal cord stimulation for improving arm and hand function

  This study is testing different ways of using spinal cord stimulation to see if it can help people with cervical spinal cord injuries improve their arm and hand function.

  Recruiting at 2 sites Columbia University · New York, New York and 1 other locations · NCT06701422

• Optimizing therapy for newly diagnosed diffuse large B-cell lymphoma using ctDNA

  This study is testing if measuring tumor DNA in the blood during treatment can help people with newly diagnosed diffuse large B-cell lymphoma get less chemotherapy if their cancer shows no signs of activity.

  Recruiting Columbia University · New York, New York · NCT06693830

• Using brodalumab to treat immune-related side effects from cancer therapy

  This study is testing if brodalumab can help cancer patients who are having immune-related side effects from their immunotherapy treatment feel better.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06673329

• Chronic convection-enhanced delivery of topotecan for recurrent IDH‑mutant malignant glioma

  This trial will try giving the chemotherapy drug topotecan directly into the brain with an implanted pump for adults with recurrent IDH‑mutant malignant glioma to see if it is safe and reaches the tumor.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06666712

• Evaluating aspirin use in heart failure patients with a heart pump

  This study is testing whether heart failure patients using a heart pump do better with or without aspirin in their blood-thinning treatment to see which option is safer and more effective.

  Recruiting at 3 sites Phase 4 Columbia University · Chicago, Illinois and 2 other locations · NCT06655376

• Program to increase physical activity among low-resourced mothers

  This study is testing a program to help low-income mothers in New York City become more active by offering free fitness classes, childcare, and support from other moms.

  Recruiting at 3 sites Columbia University · New York, New York and 9 other locations · NCT06654843

• Treatment for Low Back Pain with Discogen

  This study is testing whether the Discogen device can help people with low back and leg pain feel better compared to a fake treatment.

  Recruiting Columbia University · New York, New York · NCT06611397

• Using transcranial interference stimulation to assess social cognition

  This study is testing a new brain stimulation technique to see if it can safely help improve social thinking skills in healthy people, with hopes of using it for treating serious mental health conditions in the future.

  Recruiting Columbia University · New York, New York · NCT06607432

• Cognitive training using crossword puzzles for mild cognitive impairment

  This study is testing whether doing more crossword puzzles can help people with mild cognitive impairment think better compared to doing fewer puzzles or just learning about health.

  Recruiting at 4 sites Phase 2 Columbia University · Miami, Florida and 3 other locations · NCT06601933

• Sleep2BWell: adding sleep health to diet and activity for better blood pressure

  This program will try adding a sleep-health module to a community diet-and-exercise program to see if it helps adults with elevated blood pressure in underserved New York City neighborhoods.

  Recruiting at 2 sites Columbia University · New York, New York and 1 other locations · NCT06565104

• Predicting anxiety and memory using brain and body signals

  This study is testing a new system that uses different signals from the brain and body to see if it can better predict anxiety and memory issues in people with Temporal Lobe Epilepsy while they are in the hospital.

  Recruiting Columbia University · New York, New York · NCT06551090

• Robotic training to improve neck control in children and young adults with cerebral palsy.

  This project will try a gentle robotic system to see if it helps young people (ages 11–21) with bilateral cerebral palsy and GMFCS IV–V improve head and neck coordination.

  Recruiting Columbia University · New York, New York and 1 other locations · NCT06533293

• PiMZ Longitudinal Cohort: tracking lung changes in PiMZ Alpha-1 patients

  This project will test whether CT lung density and blood or sputum biomarkers can predict worsening emphysema over three years in adults with PiMZ alpha-1 antitrypsin deficiency and COPD.

  Recruiting Columbia University · Birmingham, Alabama and 4 other locations · NCT06505603

• Combination treatment for diffuse gastric cancer using avutometinib and defactinib

  This study is testing a new combination of two oral drugs, avutometinib and defactinib, to see if they can help people with advanced stomach cancer live longer and shrink their tumors after chemotherapy.

  Recruiting Phase 2 Columbia University · New York, New York · NCT06487221

• Using community health workers and mobile health to improve HIV treatment outcomes

  This study is testing whether using community health workers and mobile health tools can help people with HIV in the Deep South stick to their treatment and improve their health outcomes.

  Recruiting at 5 sites Columbia University · Hobson City, Alabama and 4 other locations · NCT06472206

• Using Siplizumab to prevent immune issues in liver transplant patients with autoimmune liver disease

  This study is testing if a new medication called siplizumab can help prevent immune problems in adults with autoimmune liver disease who are getting a liver transplant.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06455280

• Comparing two suction methods for intubated infants

  This study is testing whether a new suction device is better for preterm and term infants on breathing machines than the standard suction method by looking at how it affects their heart rate and oxygen levels.

  Recruiting Columbia University · New York, New York · NCT06443970

• Effects of eating walnuts on sleep quality

  This study is testing if eating walnuts can help middle-aged and older adults who have trouble sleeping get better rest compared to eating sugary foods.

  Recruiting Columbia University · New York, New York · NCT06430086

• Homecare intervention to improve outcomes for stroke patients

  This study is testing if a special homecare program with support from health workers can help stroke patients aged 18-75 who face multiple challenges feel better and recover more effectively compared to regular care.

  Recruiting Columbia University · New York, New York · NCT06397937

• Investigating insulin resistance using alpelisib in adults

  This study is testing if a drug called alpelisib can help us understand how insulin works in healthy adults compared to those at risk for type 2 diabetes.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06354088

• A multidimensional sleep health program to improve blood pressure and cardiometabolic risk

  This program tests whether a multi-part sleep health intervention can lower blood pressure and improve blood sugar, body measures, and lifestyle in adults aged 30–65 with elevated systolic blood pressure and poor sleep.

  Recruiting Columbia University · New York, New York · NCT06285968

• Monitoring heart function with a wireless sensor for heart failure patients

  This study tests whether a wireless sensor can help doctors keep a closer eye on heart function in patients with heart failure and mitral regurgitation to improve their treatment and outcomes.

  Recruiting Columbia University · New York, New York · NCT06241430

• Structural racism and reward-based brain responses linked to substance use risk in Puerto Rican adolescents

  We will try to see if signs of structural racism are linked to brain structure, reward-related brain activity, and higher substance use risk in Puerto Rican adolescents living in New York and Puerto Rico.

  Recruiting at 2 sites Columbia University · New York, New York and 1 other locations · NCT06221839

• Investigating the impact of hearing aids on cognitive decline in older adults

  This study is testing if using hearing aids can help older adults with early hearing loss and mild memory problems think better and stay socially active compared to those who only get health education.

  Recruiting Columbia University · New York, New York · NCT06174038

• Community-informed maternal sepsis safety bundle in NYC hospitals (Aim 1)

  This project will try a community-informed maternal sepsis safety bundle in four New York City hospitals to reduce sepsis during labor, birth, and the postpartum period for birthing people.

  Recruiting at 4 sites Columbia University · New York, New York and 3 other locations · NCT06145724

• Adherence support for metastatic breast cancer patients on endocrine and CDK4/6 inhibitors

  This study tests a multicomponent program to help adults with metastatic breast cancer who are not consistently taking their medications, to see if it improves adherence and considers how social factors affect their medication use.

  Recruiting Columbia University · New York, New York · NCT06121453

• Game-like cognitive training for treating OCD in young children

  This study is testing a fun video game designed to help young children with OCD improve their thinking skills and reduce their symptoms over four weeks.

  Recruiting Columbia University · New York, New York · NCT06102941

• Measuring physical activity in people with neuromuscular disorders

  This study is trying to see how much people with neuromuscular disorders move around by having them wear a device on their leg for a week every six months over three years.

  Recruiting Columbia University · New York, New York · NCT06084026

• Using gluten detection technology and telemedicine to manage celiac disease

  This study is testing if new gluten detection tools used with online support from dietitians can help newly diagnosed adults with celiac disease manage their condition better and improve their quality of life.

  Recruiting at 4 sites Columbia University · Chicago, Illinois and 3 other locations · NCT06059716

• Combining radiation therapy with immune-targeting drugs for pancreatic cancer

  This study is testing if combining radiation therapy with immune-targeting drugs can help people with localized pancreatic cancer feel better and improve their treatment outcomes before surgery.

  Recruiting at 5 sites Phase 2 Columbia University · Lake Success, New York and 4 other locations · NCT06048484

• Iron supplementation for adolescents with scoliosis

  This study tests if giving iron supplements to teenagers with scoliosis before their surgery can help them recover better and need fewer blood transfusions.

  Recruiting Columbia University · New York, New York · NCT06042699

• Identifying cardiac amyloidosis in older adults with lumbar spinal stenosis

  This study is trying to find out if older adults who have had surgery for lumbar spinal stenosis also have a heart condition called transthyretin cardiac amyloidosis by looking at their spinal tissue and using advanced technology.

  Recruiting at 5 sites Columbia University · Beverly Hills, California and 5 other locations · NCT06034405

• Genomic screening for rare diseases in newborns

  This study is testing if using advanced genetic testing for newborns can help find rare diseases earlier so that families can get support and treatment options sooner.

  Recruiting Columbia University · New York, New York · NCT05990179

• A virtual dietary education program to prevent weight gain in children with leukemia

  This study is testing a virtual nutrition program to see if it can help children with leukemia avoid gaining weight while they are receiving treatment.

  Recruiting Columbia University · New York, New York · NCT05963971

• Music intervention to help pregnant Black women with chronic stress

  Researchers will test whether a live, culturally based music session can reduce the biological impact of chronic stress during pregnancy and improve birth outcomes for Black women.

  Recruiting Columbia University · New York, New York and 1 other locations · NCT05945264

• International Childhood Leukemia Microbiome and Metabolome Cohort

  This study is trying to see how nutrition affects treatment and recovery in children aged 3 to 18 who have just been diagnosed with acute lymphoblastic leukemia.

  Recruiting at 7 sites Columbia University · New York, New York and 7 other locations · NCT05929976

• Understanding how genetics affect weight loss with a medication

  This study is testing how certain genes might affect weight loss in people taking a medication for obesity, to see if personalizing treatment can help them lose weight better.

  Recruiting Phase 4 Columbia University · New York, New York · NCT05919797

• Combining immune therapy and radiation for prostate cancer treatment

  This study is testing a new treatment that combines immune therapy drugs with targeted radiation to see if it helps men with a specific type of prostate cancer live longer and feel better.

  Recruiting Phase 2 Columbia University · New York, New York · NCT05915442

• Effects of Yo-Yo Sleep on Heart and Metabolism

  This study is testing how switching between short sleep during the week and longer sleep on weekends affects heart health and metabolism in young to middle-aged adults.

  Recruiting Columbia University · New York, New York · NCT05880758

• Adaptive radiation therapy for anal cancer

  This study is testing a new way of giving radiation therapy that changes daily based on how the tumor responds, to see if it helps people with advanced anal cancer while protecting healthy tissue.

  Recruiting Columbia University · New York, New York · NCT05838391

• Understanding the natural history of Best Vitelliform Macular Dystrophy

  This study looks at how Best Vitelliform Macular Dystrophy changes over time in people with the condition to help find better treatments in the future.

  Recruiting at 2 sites Columbia University · New York, New York and 2 other locations · NCT05809635

• Monitoring the natural history of hypoparathyroidism

  This study is tracking adults with hypoparathyroidism over three years to see how the condition affects their health and to find better ways to manage its complications.

  Recruiting Columbia University · New York, New York · NCT05793853

• Treatment of inflammation before stem cell transplant for immune disorders

  This study is testing if a new treatment can help reduce inflammation in people with immune disorders before they get a stem cell transplant to improve the chances of a successful procedure.

  Recruiting at 6 sites Phase 2 Columbia University · San Francisco, California and 12 other locations · NCT05787574

• Reducing Racism and Discrimination in HIV Care

  This study is trying to see if training programs can help reduce racism and discrimination in HIV care for BIPOC patients and healthcare workers in the Southern and Eastern U.S.

  Recruiting Columbia University · New York, New York · NCT05785169

• Non-invasive treatment for persistent Lyme disease symptoms

  This study is testing a new non-invasive treatment called vagus nerve stimulation to see if it can help people with lingering symptoms after Lyme disease who haven't found relief with antibiotics.

  Recruiting Columbia University · New York, New York · NCT05776251

• Using focused ultrasound to enhance drug delivery for brain tumors in children

  This study is testing whether using focused ultrasound can help deliver more chemotherapy directly to brain tumors in children while reducing side effects.

  Recruiting Phase 1 Columbia University · New York, New York · NCT05762419

• Effects of growth hormone and liraglutide on appetite regulation

  This study is testing if growth hormone and liraglutide can change appetite-related hormones in healthy adults and those with growth hormone deficiency to see how they affect weight and energy use.

  Recruiting Phase 4 Columbia University · New York, New York · NCT05681299

• Using photopheresis to treat early-stage Mycosis Fungoides

  This study is testing if a light-based treatment called photopheresis can help people with early-stage Mycosis Fungoides, a type of skin lymphoma, feel better.

  Recruiting Phase 2 Columbia University · New York, New York · NCT05680558

• Nutritional support for heart failure patients undergoing LVAD placement

  This study tests if giving heart failure patients a special nutritional shake before their LVAD surgery can help them recover better and avoid complications.

  Recruiting Columbia University · New York, New York · NCT05655910

• Impact of home-based walking on cognitive function in older adults with kidney disease

  This study is testing if a 6-month walking program at home can help older adults with kidney disease and memory problems improve their brain function and memory.

  Recruiting at 2 sites Columbia University · Washington D.C., District of Columbia and 1 other locations · NCT05655325

• Comparing different support methods for treating drug-resistant tuberculosis and HIV in South Africa

  This study is testing four different ways to help adults with drug-resistant tuberculosis and HIV stick to their treatment plans to see which method works best.

  Recruiting Columbia University · Durban, KwaZulu-Natal · NCT05633056

• Mindfulness and brain feedback for treating depression in teens

  This study is testing a new way to help teens with depression by using mindfulness and brain feedback to see if it can reduce negative thinking and improve their mood.

  Recruiting at 2 sites Columbia University · Boston, Massachusetts and 1 other locations · NCT05617495

• Device for dispensing opioids after cancer surgery

  This study tests a new device that gives cancer patients their pain medication after surgery to see if it's easier and safer to use than regular pill bottles.

  Recruiting Columbia University · New York, New York · NCT05585788

• Natural history study of allergic inflammation and immune disorders

  This study is looking at people with genetic allergies and immune issues to see how their bodies work and improve how we diagnose and treat these conditions.

  Recruiting Columbia University · New York, New York · NCT05584488

• A device to assist hand function for people with spinal cord injuries

  This study is testing a new device called MyHand-SCI to see if it can help people with C6-C7 spinal cord injuries improve their hand function and daily activities.

  Recruiting Columbia University · New York, New York · NCT05553457

• Intervention to improve medication adherence in breast cancer patients

  This study is testing a new program to help women with early-stage breast cancer stick to their medications for both cancer and heart health.

  Recruiting Columbia University · New York, New York · NCT05496829

• Investigating nutrition's impact on childhood cancer outcomes

  This study is trying to see how nutrition affects the health and recovery of children with leukemia and brain tumors in Southern Europe.

  Recruiting Columbia University · New York, New York · NCT05375617

• Fetal endoscopic tracheal occlusion for severe congenital diaphragmatic hernia

  This study will try placing a small balloon in the fetal windpipe (FETO) to help babies with severe congenital diaphragmatic hernia and very small lungs grow their lungs before birth.

  Recruiting Columbia University · New York, New York · NCT05354505

• Breaking up long periods of sitting to improve heart and metabolic health

  This study is testing how often and how long people should take breaks from sitting to see if it can help improve their heart and metabolic health.

  Recruiting Columbia University · New York, New York · NCT05353322

• Educational media for Latinx patients undergoing radiation therapy for breast or prostate cancer

  This study is testing new educational videos and materials to help Spanish-speaking Latinx patients better understand their radiation therapy for breast or prostate cancer and feel more involved in their treatment.

  Recruiting at 2 sites Columbia University · Miami Beach, Florida and 1 other locations · NCT05351424

• Evaluating a brief intervention for asthma management in Black adults

  This study is testing a quick 9-minute asthma management approach called BREATHE to see if it helps Black adults with uncontrolled asthma feel better and manage their condition more effectively.

  Recruiting at 2 sites Columbia University · Beacon, New York and 1 other locations · NCT05341726

• Analyzing the tumor environment in metastatic prostate cancer

  This study is trying to learn more about the environment around prostate cancer tumors in men with advanced disease by looking at tissue samples to help find new treatment options.

  Recruiting Columbia University · New York, New York · NCT05304858

• Effects of atorvastatin on inflammation in sleep apnea patients

  This study is testing if taking atorvastatin daily can lower inflammation in people with obstructive sleep apnea who are using CPAP therapy.

  Recruiting Phase 1 Columbia University · New York, New York · NCT05289063

• Using N-acetylcysteine to treat patients with a specific mitochondrial mutation and low brain glutathione levels

  This study is testing if different doses of N-acetylcysteine can help improve brain function in people with a specific mitochondrial mutation and low levels of a brain chemical called glutathione.

  Recruiting Phase 1 Columbia University · New York, New York · NCT05241262

• Using Bethanechol with Chemotherapy for Pancreatic Cancer Treatment

  This study is testing if adding bethanechol to chemotherapy can help people with pancreatic cancer have better surgery outcomes and if it's safe to use.

  Recruiting Phase 2 Columbia University · New York, New York · NCT05241249

• Mitochondrial and stress-related traits linked to preterm birth

  This project will test whether mitochondrial DNA and stress-response changes during early pregnancy are linked to the risk of having a preterm birth in pregnant women under 28 weeks.

  Recruiting Columbia University · New York, New York · NCT05229666

• Using Harmonic Motion Imaging for Non-Invasive Breast Tumor Treatment

  This study is testing if a new imaging method can help guide a non-invasive ultrasound treatment for people with benign breast tumors and early-stage breast cancer to see if it leads to better recovery and results.

  Recruiting Phase 1 Columbia University · New York, New York · NCT05219695

• Radiofrequency Ablation for Papillary Thyroid Microcarcinoma

  This study tests if a less invasive treatment called Radiofrequency Ablation can safely help people with small thyroid cancers who can’t or don’t want to have surgery.

  Recruiting Columbia University · New York, New York · NCT05189821

• Using radiofrequency ablation to treat indeterminate thyroid nodules

  This study is testing whether using radiofrequency ablation can safely treat certain thyroid nodules without the need for surgery.

  Recruiting Columbia University · New York, New York · NCT05189808

• Evaluating outcomes of radiofrequency ablation for benign thyroid nodules

  This study tests if a new treatment called radiofrequency ablation can help people with bothersome benign thyroid nodules feel better compared to traditional surgery.

  Recruiting Columbia University · New York, New York · NCT05189314

• Treatment of viral infections using rapidly generated T cells

  This study is testing a new treatment using specially made T cells to help patients with weakened immune systems who are struggling with serious viral infections like Epstein-Barr or cytomegalovirus.

  Recruiting Phase 1 Columbia University · New York, New York · NCT05183490

• Community health workers aim to reduce colorectal cancer and cardiovascular disease risk

  This study is testing a community health worker program to see if it can help African Americans lower their risk of colorectal cancer and heart disease by improving screening rates and healthy habits.

  Recruiting Columbia University · New York, New York · NCT05174286

• Understanding HIV prevention preferences among cisgender women and trans individuals

  This study is trying to understand what cisgender women and trans individuals think about HIV prevention methods like PrEP and how their choices affect their health.

  Recruiting Columbia University · New York, New York · NCT05165745

• Improving hand function after spinal cord injury using electrical stimulation

  This study is testing if a new way of using electrical stimulation on the brain and spinal cord can help people with cervical spinal cord injuries regain better control and movement in their arms and hands.

  Recruiting at 3 sites Early Phase 1 Columbia University · New York, New York and 2 other locations · NCT05163639

• Long-term saliva sampling for Barrett's esophagus

  This study is testing if regular saliva samples can help identify a specific oral bacteria pattern in people with Barrett's esophagus to see if it can be used as a simple way to diagnose this condition.

  Recruiting at 2 sites Columbia University · Ann Arbor, Michigan and 1 other locations · NCT05133102

• Investigating genetic influences on late onset Alzheimer's disease

  This study is trying to find out how genetics might affect the risk of developing late onset Alzheimer's disease by looking at families with a history of the condition.

  Recruiting at 12 sites Columbia University · Washington D.C., District of Columbia and 11 other locations · NCT05010603

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

Quick answers

How many clinical trials run by Columbia University are recruiting right now?

189, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (186 trials), Canada (2 trials), Brazil (2 trials), Argentina (1 trial), Guatemala (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 17, Phase 2: 15, Phase 4: 6, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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