Long COVID relief through learning mindfulness
Long-Covid-19 Alleviation Through Learning Mindfulness Study (LONG-CALM)
This study will try an 8-week online recorded mindfulness program to see if it reduces stress and Long COVID symptoms in adults who continue their usual care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Columbia University Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT07140094 on ClinicalTrials.gov |
What this trial studies
Adults with persistent symptoms of Post-Acute Sequelae of SARS-CoV-2 infection are randomly assigned to begin an 8-week series of recorded mindfulness sessions either immediately or after an 8-week waitlist period while continuing usual medical care. The intervention was developed specifically for people with PASC and is delivered remotely as structured recorded sessions. Outcomes (stress, PASC symptoms, and quality of life) are measured with four online surveys over six months. The trial excludes people already engaged in a structured mindfulness-based intervention or enrolled in another PASC intervention trial.
Who should consider this trial
Good fit: Adults (≥18) with a self-reported history of SARS-CoV-2 infection who have ongoing symptoms attributed to PASC for at least 12 weeks and have internet access are ideal candidates.
Not a fit: People already participating in a structured mindfulness program, enrolled in another PASC intervention trial, without persistent PASC symptoms, or without reliable internet access may not benefit from this study.
Why it matters
Potential benefit: If successful, a scalable, low-cost online mindfulness program could lower stress and reduce Long COVID symptoms, improving patients' quality of life.
How similar studies have performed: Mindfulness-based interventions have improved stress and related symptoms in multiple clinical populations in randomized trials and meta-analyses, but their specific effectiveness for Long COVID remains novel and under-studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> or = 18 * Willing and able to provide informed consent * Access to the internet * Self-reported history of SARS-CoV-2 infection * Current symptoms attributed to PASC by participant or by participant's medical provider; ongoing symptoms that persisted \>= 12 weeks after Covid-19 illness Exclusion Criteria: * Participating in another clinical trial of an intervention for PASC symptoms * Engaged in a structured MBI
Where this trial is running
New York, New York
- Columbia University — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Deborah Theodore, MD — Columbia University
- Study coordinator: Deborah Theodore, MD
- Email: dat2132@cumc.columbia.edu
- Phone: 2123058739
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.