Clinical trial Recruiting at 1 site Observational Ages 18 and up

Evaluating outcomes of radiofrequency ablation for benign thyroid nodules

Official title: Clinical Outcomes and Quality of Life Measures After Surgical Resection and Radiofrequency Ablation of Benign Thyroid Nodules

Run by Columbia University · NCT05189314 · Data updated 2026-11-12

This study tests if a new treatment called radiofrequency ablation can help people with bothersome benign thyroid nodules feel better compared to traditional surgery.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorColumbia University
Academic / other
Locations1 site (New York, New York)
StatusRecruiting
StartedAugust 30, 2019
Main results expectedAugust 2027
Study endsAugust 2028
Registry record updatedMay 29, 2026
Trial IDNCT05189314 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older with benign thyroid nodules causing symptoms.

Probably not a fit

Patients with cardiac arrhythmia or those who are pregnant may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational research aims to assess clinical outcomes and quality of life in patients with symptomatic benign multinodular goiter (MNG) after treatment. Participants will provide access to their medical information before and after undergoing either thyroidectomy or radiofrequency ablation (RFA). The study focuses on the effectiveness of RFA, a minimally invasive technique that induces local thermodestruction to shrink nodules and alleviate symptoms. By comparing outcomes, the study seeks to establish the viability of RFA as an alternative to traditional surgical methods.

Why it matters

Potential benefit: If successful, this study could provide a less invasive treatment option for patients with benign thyroid nodules, potentially reducing complications associated with surgery.

How similar studies have gone: Other studies have shown successful outcomes with radiofrequency ablation for thyroid nodules in various countries, indicating promising potential for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult patients \>/=18 years old with benign thyroid nodules

Exclusion Criteria:

* cardiac arrhythmia
* pregnancy

Where it's running

  • Columbia University
    New York, New York, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.