Evaluating outcomes of radiofrequency ablation for benign thyroid nodules
Official title: Clinical Outcomes and Quality of Life Measures After Surgical Resection and Radiofrequency Ablation of Benign Thyroid Nodules
Run by Columbia University · NCT05189314 · Data updated 2026-11-12
This study tests if a new treatment called radiofrequency ablation can help people with bothersome benign thyroid nodules feel better compared to traditional surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Columbia University Academic / other |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | August 30, 2019 |
| Main results expected | August 2027 |
| Study ends | August 2028 |
| Registry record updated | May 29, 2026 |
| Trial ID | NCT05189314 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older with benign thyroid nodules causing symptoms.
✕Probably not a fit
Patients with cardiac arrhythmia or those who are pregnant may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational research aims to assess clinical outcomes and quality of life in patients with symptomatic benign multinodular goiter (MNG) after treatment. Participants will provide access to their medical information before and after undergoing either thyroidectomy or radiofrequency ablation (RFA). The study focuses on the effectiveness of RFA, a minimally invasive technique that induces local thermodestruction to shrink nodules and alleviate symptoms. By comparing outcomes, the study seeks to establish the viability of RFA as an alternative to traditional surgical methods.
Why it matters
Potential benefit: If successful, this study could provide a less invasive treatment option for patients with benign thyroid nodules, potentially reducing complications associated with surgery.
How similar studies have gone: Other studies have shown successful outcomes with radiofrequency ablation for thyroid nodules in various countries, indicating promising potential for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients \>/=18 years old with benign thyroid nodules Exclusion Criteria: * cardiac arrhythmia * pregnancy
Where it's running
-
Columbia University
New York, New York, United States Recruiting
Study contacts
- Principal investigator: Jennifer H Kuo, MD MS — Columbia University
- Study coordinator: Jennifer H Kuo, MD MS
- Email: jhk2029@cumc.columbia.edu
- Phone: 212-305-6969
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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A New Ultrasound Probe for Thyroid Imaging with AI Analysis
Researchers are testing a new ultrasound probe called Sound Blade to see if it helps image benign thyroid nodules during standard ultrasound exams.
-
Thyroid artery embolization to relieve compressive goiters.
This will see if blocking blood flow to the thyroid (thyroid artery embolization) can safely shrink nodular goiters and relieve breathing or swallowing problems in adults who are ineligible for or decline surgery.
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Nano-pulsed Field Ablation for Benign Thyroid Nodules
This study tests whether nsPFA treatment for benign thyroid nodules helps reduce nodule size and improve symptoms in adults receiving standard care.
-
Evaluating ultrasound-guided thermal ablation for benign thyroid nodules
This study is testing if a new ultrasound-guided treatment can safely shrink benign thyroid nodules and help people feel better.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.