Brain and spinal cord MRI changes in adults with cerebral palsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, observational project will collect longitudinal clinical MR images from adults with cerebral palsy, using the Cerebral Palsy Research Network to assemble scans from across the United States. Investigators will quantify brain volume, cortical thickness, and spinal cord cross-sectional area on multiple MRIs at least 24 months apart and correlate imaging change with measures of function over time. The analysis focuses on adults aged 18–80 with no other known degenerative neurologic disease, excluding cases with significant head trauma, multiple seizures, or metallic head implants. Retrospective clinical images and prospective scans sent to Columbia will be centrally analyzed for patterns of atrophy or structural change.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have multiple MRI scans of brain and/or spinal cord spaced at least 24 months apart
* Between 18-80 years of age with at least one MRI scan after the age of 18
* No known central or peripheral neurological disease or injury other than cerebral palsy causing brain degeneration
* Inclusion in CPRN registry
* diagnosis of Cerebral Palsy
* \>18 years of age
* Have received at least one past brain MRI scan as part of standard care (patients who have two or more brain MRI scans can be included in the retrospective arm only)

Exclusion Criteria:

* History of more than one seizure in lifetime
* History of known degenerative genetic disorder
* History of brain tumor, abscess, or multiple sclerosis
* History of moderate or severe head trauma
* History of metal implants in head

Where it's running

• Weinberg Family Cerebral Palsy Center, Columbia University
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Jason Carmel, MD, PhD — Columbia University
• Study coordinator: Jason Carmel, MD, PhD
• Email: jbc28@cumc.columbia.edu
• Phone: 212-305-2700

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.