Effects of Yo-Yo Sleep on Heart and Metabolism
Impact of Yo-Yo Sleep on Cardiometabolic Health
This study is testing how switching between short sleep during the week and longer sleep on weekends affects heart health and metabolism in young to middle-aged adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 18 Years to 49 Years |
| Sex | All |
| Sponsor | Columbia University Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT05880758 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how alternating between short sleep during the week and longer sleep on weekends affects energy balance and cardiometabolic health in young-to-middle-aged adults. Participants will be assigned to one of three groups: those experiencing intermittent short sleep, those with social jetlag, and those maintaining adequate sleep. The study will last for four weeks and aims to determine whether a consistent sleep midpoint during short sleep periods leads to better health outcomes. The research addresses the real-life sleep patterns of many adults and their potential health implications.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 49 years with a BMI between 20 and 29.9 who habitually sleep 7-9 hours per night without the use of sleep aids.
Not a fit: Patients with sleep disorders, psychiatric conditions, or those who smoke may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into improving sleep patterns to enhance cardiometabolic health and reduce obesity risk.
How similar studies have performed: While some studies have explored sleep recovery effects, this approach of repeated intermittent short sleep is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 to 49 years * BMI 20-29.9 kg/m2 * Habitually sleeping 7-9 hours/night without sleep aids or naps Exclusion Criteria: * Sleep disorders * Psychiatric disorders (including eating disorders) and seasonal affective disorder * Pregnancy (current/prior year) * Breastfeeding * Smokers (Any cigarette smoking or ex-smokers \<3years) * Diabetes * Elevated blood pressure, taking beta-blockers * Individuals taking anti-coagulants or anti-platelets * Recent weight change or participation in a weight loss program or have ever had bariatric surgery or other weight loss or gastrointestinal procedure. * Travel across time zones; shift work (non-traditional hours)
Where this trial is running
New York, New York
- Columbia University Irving Medical Center — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Marie-Pierre St-Onge, PhD — Columbia University
- Study coordinator: Marie-Pierre St-Onge, PhD
- Email: ms2554@cumc.columbia.edu
- Phone: 212-305-9549
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.