Investigating genetic influences on late onset Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the genetic factors that may contribute to the risk of late onset Alzheimer's disease (AD). Researchers will recruit families and individuals of diverse ethnic backgrounds who have a family history of AD, focusing on those with multiple affected relatives. The study will involve genetic linkage analysis to identify potential genes associated with increased AD risk, beyond the known susceptibility genes. Participants will undergo blood draws and neuropsychological testing to assess cognitive function and gather relevant data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Established diagnosis of definite or probable AD or have a diagnosis of a related neurodegenerative disorder such as Frontotemporal Dementia (FTD) or Lewy Body Dementia (LBD) (will also recruit sporadic FTD and LBD) cases.
* a living sibling with probable or possible AD;
* a third living relative affected with AD (onset age 50 or older) or unaffected (60 or older);
* participants in the proband's generation with an identified companion serving as an informant;
* participants who have capacity to consent or participants lacking capacity to consent with a surrogate/proxy in place to provide consent.

Exclusion Criteria:

* failure to identify an appropriate informant;
* uncertainty of the clinical diagnosis of Alzheimer's disease or other related disorder;
* discovery of additional diagnosis that could account for the clinical manifestations;
* unwillingness to participate;
* failure to identify a living sibling with AD or other related disorder (except in the cases of sporadic FTD and sporadic LBD);
* participants lacking the capacity to consent who do not have a surrogate or proxy or next of kin to provide consent.

Where it's running

• University of Washington
  Washington D.C., District of Columbia, United States Recruiting
• University of Miami
  Miami, Florida, United States Recruiting
• Rush University
  Aurora, Illinois, United States Recruiting
• Indiana University
  Bloomington, Indiana, United States Recruiting
• NCRAD at Indiana University
  Indianapolis, Indiana, United States Recruiting
• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Richard P. Mayeux, MD, MSc — Columbia University
• Study coordinator: Dolly Reyes-Dumeyer
• Email: dr2290@cumc.columbia.edu
• Phone: 212-305-5953

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.